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Legendorf Bugs Bunny

German Pinscher

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Registration

N/A : VDH17DP03U00089

Genetic Breed Result

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German Pinscher

The German Pinscher is a medium-sized breed of dog, a Pinscher type that originated in Germany. The breed is included in the origins of the Dobermann, the Rottweiler, the Miniature Pinscher, the Affenpinscher, the Standard Schnauzer.

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Genetic Stats

Predicted Adult Weight

49 lbs

Genetic Age
53 human years

Based on the date of birth provided

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Health Summary

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Legendorf Bugs Bunny inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Degenerative Myelopathy, DM

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Legendorf Bugs Bunny inherited one copy of the variant we tested

What does this result mean?

Because this variant is inherited in an autosomal recessive manner (meaning dogs need two copies of the variant to develop the disease), Legendorf Bugs Bunny is unlikely to develop this condition due to the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of his offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Degenerative Myelopathy, DM?

The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.

ALT Activity

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Legendorf Bugs Bunny inherited both copies of the variant we tested

Why is this important to your vet?

Legendorf Bugs Bunny has two copies of a variant in the GPT gene and is likely to have a lower than average baseline ALT activity. ALT is a commonly used measure of liver health on routine veterinary blood chemistry panels. As such, your veterinarian may want to watch for changes in Legendorf Bugs Bunny's ALT activity above their current, healthy, ALT activity. As an increase above Legendorf Bugs Bunny’s baseline ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Von Willebrand Disease Type I, Type I vWD (VWF)

Identified in German Pinschers

Additional Genetic Conditions

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Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Legendorf Bugs Bunny’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

C2

Haplotype

C19

Map

C2

Legendorf Bugs Bunny’s Haplogroup

C2 is a very old female lineage found more commonly among English Setters, English Bulldogs, and American Eskimo Dogs. We also see C2 in village dogs in South Asia. Rather than having a few characteristic breeds representing this lineage particularly well, it is present in a few uncommon individuals of many different breeds. Unlike some European breed lineages that have seen skyrocketing popularity along the path to the modern dogs we see today, C2 tends to reflect the deep history of man's best friend.

C19

Legendorf Bugs Bunny’s Haplotype

Part of the C2 haplogroup, this haplotype occurs most commonly in Boxers. It’s a rare find!

Some other Embark dogs with this haplotype:

You can often find his haplogroup in the lovable English Bulldog.

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Through Legendorf Bugs Bunny’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1

Haplotype

Ha.1

Map

A1

Legendorf Bugs Bunny’s Haplogroup

A1 is the male lineage in several breeds that aren't very closely related to each other. Gordon Setters, Newfoundlands, and Miniature Schnauzers all had male founders from this paternal line, and now many males in those breeds carry their Y chromosome. Each of these breeds started in the past 200-300 years, and their founders must have included dogs that trace back to the same male ancestors deeper in dog evolutionary time, stretching all the way back to when dogs were first domesticated in Central Asia about 15,000 years ago. Unlike many Y chromosome (male) lineages found in European and recent American breeds, only one village dog (in Alaska) carries an A1 Y chromosome, indicating that the breeds from this lineage probably didn't travel around the world with European colonization as much as some other breeds.

Ha.1

Legendorf Bugs Bunny’s Haplotype

The lone member of the A1 haplogroup, this haplotype occurs in Newfoundlands, Miniature Schnauzers, Gordon Setters, and village dogs in Alaska.

Some other Embark dogs with this haplotype:

The Newfoundland is from the A1 paternal line.

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