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“Papi”
Lady's Princess Papi bySarge RSJ

Labrador Retriever

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Place of Birth

Brooksville, FL, USA

Current Location

Brooksville, Florida, USA

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Registration

American Kennel Club (AKC): SS22726501

Genetic Breed Result

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Labrador Retriever

The Labrador Retriever was bred for hunting and excelled in retrieving game after it was shot down. Known for its gentle disposition and loyalty, the Labrador Retriever has become a favorite of families and breeders alike.

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Genetic Stats

Predicted Adult Weight

52 lbs

Genetic Age
24 human years

Based on the date of birth provided

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Health Summary

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Papi inherited three variants that you should learn more about.

Progressive Retinal Atrophy, prcd

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Papi inherited one copy of the variant we tested

What does this result mean?

This result should not impact Papi’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring.

What is Progressive Retinal Atrophy, prcd?

PRA-prcd is a retinal disease that causes progressive, non-painful vision loss. The retina contains cells, called photoreceptors, that collect information about light and send signals to the brain. There are two types of photoreceptors: rods, for night vision and movement, and cones, for day vision and color. This type of PRA leads to early loss of rod cells, leading to night blindness before day blindness.

Exercise-Induced Collapse, EIC

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Papi inherited one copy of the variant we tested

What does this result mean?

This result should not impact Papi’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring.

What is Exercise-Induced Collapse, EIC?

EIC has been linked to a mutation in the DNM1 gene, which codes for the protein dynamin. In the neuron, dynamin trucks neurotransmitter-filled vesicles from the cell body, where they are generated, to the dendrites. It is hypothesized in dogs affected with EIC, the mutation in DNM1 disrupts efficient neurotransmitter release, leading to a cessation in signalling and EIC.

Hereditary Nasal Parakeratosis, HNPK

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Papi inherited one copy of the variant we tested

What does this result mean?

This result should not impact Papi’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring.

What is Hereditary Nasal Parakeratosis, HNPK?

This condition causes the skin of the nose to be overly thick and shingle-like, which can be uncomfortable for your dog.

Breed-Relevant Genetic Conditions

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Canine Elliptocytosis (SPTB Exon 30)

Identified in Labrador Retrievers

Pyruvate Kinase Deficiency (PKLR Exon 7, Labrador Retriever Variant)

Identified in Labrador Retrievers

Golden Retriever Progressive Retinal Atrophy 2, GR-PRA2 (TTC8)

Identified in Labrador Retrievers

Progressive Retinal Atrophy, crd4/cord1 (RPGRIP1)

Identified in Labrador Retrievers

Day Blindness (CNGA3 Exon 7, Labrador Retriever Variant)

Identified in Labrador Retrievers

Macular Corneal Dystrophy, MCD (CHST6)

Identified in Labrador Retrievers

Urate Kidney & Bladder Stones (SLC2A9)

Identified in Labrador Retrievers

Alexander Disease (GFAP)

Identified in Labrador Retrievers

Narcolepsy (HCRTR2 Intron 6, Labrador Retriever Variant)

Identified in Labrador Retrievers

Ullrich-like Congenital Muscular Dystrophy (COL6A3 Exon 10, Labrador Retriever Variant)

Identified in Labrador Retrievers

Centronuclear Myopathy, CNM (PTPLA)

Identified in Labrador Retrievers

X-Linked Myotubular Myopathy (MTM1, Labrador Retriever Variant)

Identified in Labrador Retrievers

Congenital Myasthenic Syndrome, CMS (COLQ, Labrador Retriever Variant)

Identified in Labrador Retrievers

Skeletal Dysplasia 2, SD2 (COL11A2, Labrador Retriever Variant)

Identified in Labrador Retrievers

Additional Genetic Conditions

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Clinical Tools

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Through Papi’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

A400

Map

A1a

Lady's Princess Papi bySarge RSJ’s Haplogroup

A1a is the most common maternal lineage among Western dogs. This lineage traveled from the site of dog domestication in Central Asia to Europe along with an early dog expansion perhaps 10,000 years ago. It hung around in European village dogs for many millennia. Then, about 300 years ago, some of the prized females in the line were chosen as the founding dogs for several dog breeds. That set in motion a huge expansion of this lineage. It's now the maternal lineage of the overwhelming majority of Mastiffs, Labrador Retrievers and Gordon Setters. About half of Boxers and less than half of Shar-Pei dogs descend from the A1a line. It is also common across the world among village dogs, a legacy of European colonialism.

A400

Lady's Princess Papi bySarge RSJ’s Haplotype

Part of the A1a haplogroup, this haplotype occurs most frequently in mixed breed dogs.

Some other Embark dogs with this haplotype:

Shar Pei dogs think A1a is the coolest!

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Papi inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Papi is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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