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“Clementine”
Lady Clementine

Cockapoo

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Place of Birth

Holton, Indiana, USA

Current Location

Puyallup, Washington, USA

From

Holton, Indiana, USA

This dog has been viewed and been given 3 wags

Registration

N/A : OZALOO2805

Genetic Breed Result

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Cocker Spaniel

Cocker Spaniels are handsome and intelligent hunting dogs that are also well-suited to life as a loving family pet.

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Poodle (Small)

A highly intelligent and playful dog, Miniature and Toy Poodles make for great lap dogs and companions.

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Genetic Stats

Predicted Adult Weight

23 lbs

Genetic Age
31 human years

Based on the date of birth provided

DNA Breed Origins

Breed colors:
Cocker Spaniel
Poodle (Small)

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Health Summary

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Clementine is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Intervertebral Disc Disease (Type I)

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Clementine inherited one copy of the variant we tested

How to interpret this result

Clementine has one copy of an FGF4 retrogene on chromosome 12. In some breeds such as Beagles, Cocker Spaniels, and Dachshunds (among others) this variant is found in nearly all dogs. While those breeds are known to have an elevated risk of IVDD, many dogs in those breeds never develop IVDD. For mixed breed dogs and purebreds of other breeds where this variant is not as common, risk for Type I IVDD is greater for individuals with this variant than for similar dogs.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

ALT Activity

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Clementine inherited one copy of the variant we tested

Why is this important to your vet?

Clementine has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Clementine has this genotype, as ALT is often used as an indicator of liver health and Clementine is likely to have a lower than average resting ALT activity. As such, an increase in Clementine’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Von Willebrand Disease Type I, Type I vWD (VWF)

Identified in Small Poodles

Progressive Retinal Atrophy, prcd (PRCD Exon 1)

Identified in Cocker Spaniels and Small Poodles

Familial Nephropathy (COL4A4 Exon 3, Cocker Spaniel Variant)

Identified in Cocker Spaniels

Glycogen storage disease Type VII, Phosphofructokinase Deficiency, PFK Deficiency (PFKM, Whippet and English Springer Spaniel Variant)

Identified in Cocker Spaniels

GM2 Gangliosidosis (HEXB, Poodle Variant)

Identified in Small Poodles

Neonatal Encephalopathy with Seizures, NEWS (ATF2)

Identified in Small Poodles

Acral Mutilation Syndrome (GDNF-AS, Spaniel and Pointer Variant)

Identified in Cocker Spaniels

Exercise-Induced Collapse, EIC (DNM1)

Identified in Cocker Spaniels

Osteochondrodysplasia (SLC13A1, Poodle Variant)

Identified in Small Poodles

Additional Genetic Conditions

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Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Clementine’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A4

Haplotype

A455

Map

A4

Lady Clementine’s Haplogroup

The A4 maternal lineage is fairly rare. It is found in Cocker Spaniels, but A4 is also represented well among East Asian breeds including the Chinese Crested Dog, Shar-Pei and Shih Tzu. Moving away from Asia, it is also found among Chihuahuas (a very old breed!) and village dogs in Peru. This may be a lineage that moved into Western breeds because of their owners' tendencies to mix them up with Eastern breeds in the early modern period.

A455

Lady Clementine’s Haplotype

Part of the A4 haplogroup, this haplotype occurs most frequently in mixed breed dogs.

Some other Embark dogs with this haplotype:

The popular Chihuahua breed descends from the A4 maternal line.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Clementine inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Clementine is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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