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Acrux

No bio has been provided yet

Instagram tag
@acrux_lupul.mic

Place of Birth
Kentucky, USA
Current Location
Chesapeake, Virginia, USA
From
Kentucky, USA

This dog has been viewed 163 times and been given 21 wags

Genetic Breed Result

Learn how it’s done
31.2% Gray Wolf
20.4% American Pit Bull Terrier
11.4% Alaskan Malamute
7.4% German Shepherd Dog
6.9% Golden Retriever
6.7% Chinese Shar-Pei
4.1% Boxer
11.9% Unresolved

Embark Supermutt analysis

What’s in that Supermutt? There may be small amounts of DNA from these distant ancestors:

Start a conversation! Message this dog’s owner.

Genetic Stats


Predicted Adult Weight
Genetic Age
15 human years Learn More
Based on the date of birth provided

DNA Breed Origins

What’s this?
Breed colors:
Gray Wolf
American Pit Bull Terrier
Alaskan Malamute
German Shepherd Dog
Golden Retriever
Chinese Shar-Pei
Boxer
Unresolved
Changes to this dog’s profile
Learn More
  • On 3/14/2020 changed name from "Korra Blue" to "Acrux"
  • On 3/14/2020 changed name from "Korra Blue Male" to "Korra Blue"

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Health Summary

Acrux is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Multiple Drug Sensitivity

Acrux inherited one copy of the variant we tested

How to interpret this result

Acrux has one copy of a variant at the ABCB1 gene and is at risk for displaying adverse drug reactions. While he may not be as severely affected as a dog with two copies of the ABCB1 drug sensitivity allele, normal dosages of drugs could still have potentially severe effects on Acrux. Please inform your veterinarian that Acrux carries this variant; it is essential that they know this information before prescribing drugs.

What is Multiple Drug Sensitivity?

Sensitivity to certain classes of drugs, notably the parasiticide ivermectin, as well as certain gastroprotectant and anti-cancer medications, occurs in dogs with a mutation in the ABCB1 gene.

Neuronal Ceroid Lipofuscinosis 1, Cerebellar Ataxia, NCL4A

Acrux inherited one copy of the variant we tested

What does this result mean?

This result should not impact Acrux’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of his offspring.

What is Neuronal Ceroid Lipofuscinosis 1, Cerebellar Ataxia, NCL4A?

A lysosome is a structure within the cell that digests and removes waste. When the lysosome cannot recycle waste properly, the waste accumulates and causes the cell to die. This form of lysosomal storage disease causes adult onset neurologic signs.

Breed-Relevant Genetic Conditions

Factor VII Deficiency (F7 Exon 5)

Identified in Alaskan Malamutes

Hemophilia A (F8 Exon 10, Boxer Variant)

Identified in Boxers

Hemophilia A (F8 Exon 11, Shepherd Variant 1)

Identified in German Shepherd Dogs

Hemophilia A (F8 Exon 1, Shepherd Variant 2)

Identified in German Shepherd Dogs

Canine Leukocyte Adhesion Deficiency Type III, CLADIII (FERMT3)

Identified in German Shepherd Dogs

Congenital Macrothrombocytopenia (TUBB1 Exon 1, Cavalier King Charles Spaniel Variant)

Identified in Boxers

Platelet factor X receptor deficiency, Scott Syndrome (TMEM16F)

Identified in German Shepherd Dogs

Progressive Retinal Atrophy, prcd (PRCD Exon 1)

Identified in Golden Retrievers

Golden Retriever Progressive Retinal Atrophy 1, GR-PRA1 (SLC4A3)

Identified in Golden Retrievers

Golden Retriever Progressive Retinal Atrophy 2, GR-PRA2 (TTC8)

Identified in Golden Retrievers

Progressive Retinal Atrophy, crd1 (PDE6B)

Identified in American Pit Bull Terriers

Day Blindness (CNGA3 Exon 7 German Shepherd Variant)

Identified in German Shepherd Dogs

Glaucoma (ADAMTS17 Exon 2)

Identified in Chinese Shar-Peis

Urate Kidney & Bladder Stones (SLC2A9)

Identified in American Pit Bull Terriers and German Shepherd Dogs

Anhidrotic Ectodermal Dysplasia (EDA Intron 8)

Identified in German Shepherd Dogs

Renal Cystadenocarcinoma and Nodular Dermatofibrosis (FLCN Exon 7)

Identified in German Shepherd Dogs

Mucopolysaccharidosis Type VII, Sly Syndrome, MPS VII (GUSB Exon 3)

Identified in German Shepherd Dogs

Neuronal Ceroid Lipofuscinosis (CLN5 Golden Retriever Variant)

Identified in Golden Retrievers

Shar-Pei Autoinflammatory Disease, SPAID, Shar-Pei Fever (MTBP)

Identified in Chinese Shar-Peis

Degenerative Myelopathy, DM (SOD1A)

Identified in Boxers, German Shepherd Dogs, and more

L-2-Hydroxyglutaricaciduria, L2HGA (L2HGDH)

Identified in American Pit Bull Terriers

Polyneuropathy, NDRG1 Malamute Variant (NDRG1 Exon 4)

Identified in Alaskan Malamutes

Muscular Dystrophy (DMD Golden Retriever Variant)

Identified in Golden Retrievers

Dystrophic Epidermolysis Bullosa (COL7A1)

Identified in Golden Retrievers

Ichthyosis (PNPLA1)

Identified in Golden Retrievers

Osteogenesis Imperfecta (COL1A1)

Identified in Golden Retrievers

Additional Genetic Conditions


Clinical Tools

Explore the genetics behind your dog’s appearance and size.
Coat Color

Coat Color

E Locus (MC1R)
No dark mask or grizzle (Ee)
K Locus (CBD103)
More likely to have a mostly solid black or brown coat (KBKB)
A Locus (ASIP)
Not expressed (ayat)
D Locus (MLPH)
Dark areas of hair and skin are not lightened (DD)
B Locus (TYRP1)
Black or gray hair and skin (BB)
Saddle Tan (RALY)
Not expressed (NI)
M Locus (PMEL)
No merle alleles (mm)
H Locus (Harlequin)
No harlequin alleles (hh)
Other Coat Traits

Other Coat Traits

Furnishings (RSPO2) LINKAGE
Likely unfurnished (no mustache, beard, and/or eyebrows) (II)
Coat Length (FGF5)
Likely short or mid-length coat (GT)
Shedding (MC5R)
Likely heavy/seasonal shedding (CT)
Coat Texture (KRT71)
Likely straight coat (CC)
Hairlessness (FOXI3) LINKAGE
Very unlikely to be hairless (NN)
Hairlessness (SGK3)
Very unlikely to be hairless (NN)
Oculocutaneous Albinism Type 2 (SLC45A2) LINKAGE
Likely not albino (NN)
Other Body Features

Other Body Features

Muzzle Length (BMP3)
Likely medium or long muzzle (AC)
Tail Length (T)
Likely normal-length tail (CC)
Hind Dewclaws (LMBR1)
Unlikely to have hind dew claws (CC)
Blue Eye Color (ALX4) LINKAGE
Less likely to have blue eyes (NN)
Back Muscling & Bulk, Large Breed (ACSL4)
Likely normal muscling (CC)
Body Size

Body Size

Body Size (IGF1)
Larger (NN)
Body Size (IGFR1)
Larger (GG)
Body Size (STC2)
Larger (TT)
Body Size (GHR - E191K)
Larger (GG)
Body Size (GHR - P177L)
Larger (CC)
Performance

Performance

Altitude Adaptation (EPAS1)
Normal altitude tolerance (GG)
Appetite (POMC) LINKAGE
Normal food motivation (NN)

Through Acrux’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1d

Haplotype

A41

Map

A1d

Acrux’s Haplogroup

This female lineage can be traced back about 15,000 years to some of the original Central Asian wolves that were domesticated into modern dogs. The early females that represent this lineage were likely taken into Eurasia, where they spread rapidly. As a result, many modern breed and village dogs from the Americas, Africa, through Asia and down into Oceania belong to this group! This widespread lineage is not limited to a select few breeds, but the majority of Rottweilers, Afghan Hounds and Wirehaired Pointing Griffons belong to it. It is also the most common female lineage among Papillons, Samoyeds and Jack Russell Terriers. Considering its occurrence in breeds as diverse as Afghan Hounds and Samoyeds, some of this is likely ancient variation. But because of its presence in many modern European breeds, much of its diversity likely can be attributed to much more recent breeding.

A41

Acrux’s Haplotype

Part of the large A1d haplogroup, we have not spotted this haplotype in village dogs yet. We do see it in 3 breeds: Alaskan Malamutes, Bichon Frises, and Posavac Hounds.

Some other Embark dogs with this haplotype:

The vast majority of Rottweilers have the A1d haplogroup.

Through Acrux’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

D

Haplotype

H10.1/Hd.4

Map

D

Acrux’s Haplogroup

The D paternal lineage is very common in well-known populations of dogs. Breeds belonging to the D lineage likely have direct male ancestors that can be traced all the way back to the origin of domestic dogs themselves! One popular breed that commonly sports a D lineage is the Boxer. Boxers were developed in the late 19th century from Mastiff dogs, so it is no surprise that D is well represented among Mastiffs, Bulldogs, as well as Terriers. Intriguingly, D is also found among Lhasa Apsos, an ancient Tibetan breed, and Afghan Hounds. While the presence of this lineage in Polynesia or the New World can be chalked up to interbreeding with European dogs brought during voyages of discovery or later settlement, D is also well represented among village dog populations in the Middle East and Africa. If the fact that we find dogs bearing a D lineage in the Middle East (not to mention the large amount of diversity among Middle Eastern D lineage males) is any indication of ancient residence in that region, then the presence among Oceanian village dogs is peculiar. Rather, it may be that D is part of a broader Eurasian group of ancient paternal lineages which disappeared from the eastern portion of its original range, persisting in the island of New Guinea as well as West Asia and Africa. With the rise of Mastiff breeds, the D lineage received a new life as it became common among many types of working dogs.

H10.1/Hd.4

Acrux’s Haplotype

Part of the D haplogroup, this haplotype occurs most frequently in mixed breed dogs.

Some other Embark dogs with this haplotype:

The D paternal lineage is common in Boxers.