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Ares

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Genetic Stats

Wolfiness: 41.8 % HIGH
Predicted Adult Weight: 82 lbs
Genetic Age: 11 human years

Breed Mix By Chromosome

Our advanced test identifies from where Ares inherited every part of the chromosome pairs in his genome. Each chromosome section is colored to represent the breed that it comes from.

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Health

>
We have tested Ares for over 160 genetic health conditions to alert his owner to potential issues before they strike.

Traits

>
Genes for coat color and type, body size and shape, and other characteristics.

Maternal Haplotype

>
Through the DNA inherited from Ares’s mother we can trace his ancestry back to where dogs and people first became friends. Find out how far Ares’s family has traveled.

Paternal Haplotype

>
The Y-Chromosome is only passed down from father to son. Ares’s DNA includes a story of where his father’s ancestors came from. We’ll show you more about how we categorize his ancestors all based of the science of genetics.

Let us know and we will contact Ares’s owner and make sure he is reunited with his family soon! Thank you for helping out our furry friends.

What’s your dog’s story?

Now that you have explored what’s behind Ares find out what your dog’s DNA has to tell you. Embark tells you more about your dog than you ever thought possible. Are you ready? Let’s go!

Changes to this dog’s profile
  • On 5/2/2018 changed name from "Khan" to "Ares"
What’s this?

Summary

0
AT RISK
0
CARRIER
163
CLEAR
Tap above or scroll down to see more

Clinical traits

These genetic traits are valuable to your veterinarian and can inform the clinical decisions and diagnoses they make.

Alanine Aminotransferase Activity result: Normal
Known to be highly expressed in liver cells, activity levels of alanine aminotransferase, or ALT, is a common value on most blood chemistry panels and is known to be a se…
Ares has two normal alleles at ALT.

Not At Risk

Good news! Ares did not test positive for any of the genetic diseases that Embark screens for. Read on to learn more about the conditions we test for, but rest assured that Ares does not have the mutations known to cause them.

It is still important to let your veterinarian know these results because they could help guide Ares’s diagnosis and treatment if he gets sick in the future. Many other diseases caused by environmental factors or undiscovered genetic variants can cause symptoms similar to diseases we test for. By ruling out these mutations, your veterinarian will be able to find the true cause more quickly. Your veterinarian will also know they can safely prescribe medications some dogs are sensitive to.

Not A Carrier

Good news! Ares is not a carrier for any of the genetic diseases that Embark tests for.

Common Conditions

Good news! Ares tested clear for 13 genetic conditions that are common in his breed mix.
Condition List

MDR1 Drug Sensitivity
(MDR1)
Clinical

Sensitivity to certain classes of drugs, notably the parasiticide ivermectin, as well as certain gastroprotectant and anti-cancer medications, occurs in dogs with mutatio…

Seen in German Shepherd Dogs, but not Ares.

Factor VII Deficiency
(F7 Exon 5)
Blood

Coagulopathies represent a broad category of diseases that affect blood clotting, which can lead to symptoms such as easy bruising or bleeding. Dogs with coagulopathies a…

Seen in Alaskan Malamutes, but not Ares.

Factor VIII Deficiency, Hemophilia A
(F8 Exon 11, Shepherd Variant 1)
Blood

Coagulopathies represent a broad category of diseases that affect blood clotting, which can lead to symptoms such as easy bruising or bleeding. Dogs with coagulopathies a…

Seen in German Shepherd Dogs, but not Ares.

Factor VIII Deficiency, Hemophilia A
(F8 Exon 1, Shepherd Variant 2)
Blood

Coagulopathies represent a broad category of diseases that affect blood clotting, which can lead to symptoms such as easy bruising or bleeding. Dogs with coagulopathies a…

Seen in German Shepherd Dogs, but not Ares.

Canine Leukocyte Adhesion Deficiency Type III (LAD3)
(FERMT3)
Blood

A rare disorder of white blood cells, this causes increased susceptibility to infections and bleeding tendencies. Affected dogs present with a history of persistent skin …

Seen in German Shepherd Dogs, but not Ares.

Achromatopsia
(CNGA3 Exon 7 German Shepherd Variant)
Eyes

This is a progressive, nonpainful disorder of the retina that affects color vision and light perception. Cone cells not only register color, they allow the dog to adjust …

Seen in German Shepherd Dogs, but not Ares.

X-linked Ectodermal Dysplasia, Anhidrotic Ectodermal Dysplasia
(EDA Intron 8)
Multisystem

This developmental condition can cause a scanty haircoat, malformed teeth, and few or absent sweat glands. Because dogs only have sweat glands on their paw pads, they are…

Seen in German Shepherd Dogs, but not Ares.

Renal Cystadenocarcinoma and Nodular Dermatofibrosis (RCND)
(FLCN Exon 7)
Multisystem

A multiorgan syndrome best described in the German Shepherd Dog, affected dogs display thick skin nodules and signs of kidney disease, and should be evaluated by a veteri…

Seen in German Shepherd Dogs, but not Ares.

Mucopolysaccharidosis Type VII, Sly Syndrome
(GUSB Exon 3)
Multisystem

A type of lysosomal storage disease, this can cause skeletal abnormalities, growth retardation, and gait abnormalities, and can require close monitoring and special measu…

Seen in German Shepherd Dogs, but not Ares.

GM1 Gangliosidosis
(GLB1 Exon 15 Alaskan Husky Variant)
Multisystem

An early onset form of lysosomal storage disease, this can cause affected dogs to display neurologic signs as puppies or young adults. These include partial or total visi…

Seen in Siberian Huskys, but not Ares.

Degenerative Myelopathy
(SOD1A)
Brain and Spinal Cord

A disease of mature dogs, this is a progressive degenerative disorder of the spinal cord that can cause muscle wasting and gait abnormalities. Affected dogs do not usuall…

Seen in Gray Wolfs, German Shepherd Dogs, Siberian Huskys, Alaskan Malamutes, but not Ares.

Polyneuropathy, NDRG1 Malamute Variant
(NDRG1 Exon 4)
Brain and Spinal Cord

Polyneuropathy is a progressive neurologic disease that causes peripheral nerve dysfution. Peripheral nerves relay messages between the brain and spinal cord to the rest …

Seen in Alaskan Malamutes, but not Ares.

Malignant Hyperthermia
(RYR1)
Metabolic

This condition only manifests if affected dogs are treated with certain inhalant anesthetics, and can cause uncontrollable muscle contractions and a dangerous increase in…

Seen in Gray Wolfs, German Shepherd Dogs, Siberian Huskys, Alaskan Malamutes, but not Ares.

Other Conditions: Clear of 150

Ares is clear of 150 other genetic diseases that Embark tests for.

Explore more

Swipe left and right to explore more results, or choose a category below

Traits

>
Genes for coat color and type, body size and shape, and other characteristics.

Maternal Haplotype

>
Through the DNA inherited from Ares’s mother we can trace his ancestry back to where dogs and people first became friends. Find out how far Ares’s family has traveled.

Paternal Haplotype

>
The Y-Chromosome is only passed down from father to son. Ares’s DNA includes a story of where his father’s ancestors came from. We’ll show you more about how we categorize his ancestors all based of the science of genetics.

What’s your dog’s story?

Now that you have explored what’s behind Ares find out what your dog’s DNA has to tell you. Embark tells you more about your dog than you ever thought possible. Are you ready? Let’s go!

Coat Color

A number of genetic loci are known to affect coat color in dogs, and they all interact. In some cases, other genetic effects may also influence color and pattern.

E Locus (Mask, Grizzle, Recessive Red)
EE
Chromosome 5

Controls the characteristic melanistic mask seen in the German Shepherd and Pug as well as the grizzled "widow's peak" of the Afghan and Borzoi. Melanistic mask (Em) is dominant to grizzle (Eg) which is dominant to black (E) and red (e). Dogs that are EE or Ee are able to produce normal black pigment, but its distribution will be dependent on the genotypes at the K and A Loci. Dogs that are ee will be a shade of red or cream regardless of their genotype at K and A. The shade of red, which can range from a deep copper like the Irish Setter to the near-white of some Golden Retrievers, is dependent on other genetic factors including the Intensity (I) Locus, which has yet to be genetically mapped.

Want to help us map I Locus? If you haven't already, complete your ee pup's Embark profile with a photo! Remember, a picture is worth a thousand words!

Citations: Schmutz et al 2003 , Dreger and Schmutz 2010 ,

More information: http://www.doggenetics.co.uk/masks.html

K Locus (Dominant Black)
KBky
Chromosome 16

Causes a dominant black coat. Dogs with a dominant KB allele have black coats regardless of their genotype at the A locus; the coat color of dogs homozygous for the recessive ky allele are controlled by A locus. Alleles: KB > ky

Citations: Candille et al 2007

More information: http://www.doggenetics.co.uk/black.htm

A Locus (Agouti, Sable)
No Call
Chromosome 24

Determines whether hair pigment is produced in a banded red and black pattern or solid black. Fawn or sable (ay) is dominant to wolf sable (aw) which is dominant to black-and-tan (at), which is in turn dominant to recessive black (a).

Citations: Berryere et al 2005 , Dreger and Schmutz 2011 ,

More information: http://www.doggenetics.co.uk/tan.html

D Locus (Dilute, Blue, Fawn)
Dd
Chromosome 25

Lightens a black coat to blue and a red coat to buff. A dilute phenotype requires two copies of the recessive d allele.

Citations: Drogemuller et al 2007

More information: http://www.doggenetics.co.uk/dilutes.html

B Locus (Brown, Chocolate, Liver, Red)
BB
Chromosome 11

Lightens a black coat to brown, chocolate or liver. The brown phenotype requires two copies of the recessive b allele. Red or cream dogs that carry two b alleles remain red or cream but have brown noses and footpads.

Citations: Schmutz et al 2002

More information: http://www.doggenetics.co.uk/liver.html

Other Coat Traits

Furnishings, shedding and curls are all genetic! And they all interact, too. In fact, the combination of these genetic loci explain the coat phenotypes of 90% of AKC registered dog breeds.

For more information on the genetics of coat types you can refer to https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897713/figure/F3/

Some other Embark dogs with this Coat Traits genotype:

Furnishings / Improper Coat (RSPO2)
II
Chromosome 13

Confers the distinguished moustache, beard, and eyebrows characteristic of breeds like the Schnauzer, Scottish Terrier, and Wire Haired Dachshund; only one copy of the dominant F allele is required for furnishings. The FI genotype is furnished but carries one allele for no furnishings, or improper coat. A dog with two I alleles has improper coat. The mutation is a 167-bp insertion which we measure indirectly using linked markers highly correlated with the insertion.

Citations: Cadieu et al 2010

Long Haircoat (FGF5)
TT
Chromosome 32

The FGF5 gene is known to affect hair length in many different species, including cats, dogs, mice, and humans! The "T" allele confers a long, silky haircoat as observed in the Yorkshire Terrier and the Long Haired Whippet. The ancestral "G" allele causes a shorter coat as seen in the Boxer or the American Staffordshire Terrier.

Citations: Housley & Venta 2006 , Cadieu et al 2010

Shedding (MC5R)
CC
Chromosome 1

Affects shedding propensity in non-wire-haired dogs. Dogs with the ancestral C allele, like many Labradors and German Shepherd Dogs, are heavy or seasonal shedders, while those with one or more T allele, including many Boxers, Shih Tzus and Chihuahuas, tend to be low shedders. Dogs with furnished/wire-haired coats tend to be low shedders regardless of their MC5R genotype.

Citations: Hayward et al 2016

Curly Coat (KRT71)
CC
Chromosome 27

Causes the curly coat characteristic of Poodles and Bichons Frises. Dogs need at least one copy of the "T" allele to have a wavy or curly coat; the ancestral "C" allele is associated with a straight coat.

Citations: Cadieu et al 2010

Other Body Features

Brachycephaly (BMP3)
CC
Chromosome 32

Affects skull size and shape. Many brachycephalic or "smushed face” breeds such as the English Bulldog, Pug, and Pekingese have two copies of the derived A allele. Mesocephalic (Staffordshire Terrier, Labrador) and dolichocephalic (Whippet, Collie) dogs have one, or more commonly two, copies of the ancestral C allele. At least five different genes affect snout length in dogs, with BMP3 being the only one with a known causal mutation. For example, the skull shape of some breeds, including the dolichocephalic Scottish Terrier or the brachycephalic Japanese Chin, appear to be caused by other genes.

Citations: Schoenbeck et al 2012

Natural Bobtail (T)
CC
Chromosome 1

Whereas most dogs have two C alleles and a long tail, dogs with one G allele are likely to have a bobtail, which is an unusually short or absent tail. This mutation causes natural bobtail in many breeds including the Pembroke Welsh Corgi, the Australian Shepherd, and the Brittany Spaniel. Dogs with GG genotypes have not been observed, suggesting that the GG genotype results in embryonic lethality.

Please note that this mutation does not explain every natural bobtail! While certain lineages of Boston Terrier, English Bulldog, Rottweiler, Miniature Schnauzer, Cavalier King Charles Spaniel, and Parson Russell Terrier, and Dobermans are born with a natural bobtail, these breeds do not have this mutation. This suggests that other unknown genetic mutations can also lead to a natural bobtail. If your dog does not have a CG genotype but was born with a bobtail, please email us at howdy@embarkvet.com!

Citations: Haworth et al 2001 , Hytonen et al 2009

Hind Dewclaws (LMBR1)
CC
Chromosome 16

Common in certain breeds, hind dewclaws are extra, nonfunctional digits located midway between your dog's paw and hock. Dogs with at least one copy of the T allele have about a 50% of chance of having hind dewclaws.

Citations: Park et al 2008

Body Size

Body size is a complex trait that is affected by both genetic and environmental variation. Our genetic analysis includes genes that, together, explain over 80% of the variation in dog body size. It does not account for runting or stunting; nor does it account for the interactions between various genes both known and unknown.

Some other Embark dogs with this Body Size genotype:

Body Size - IGF1
NN
Chromosome 15

The "I" allele is associated with smaller size.

Citations: Sutter et al 2007

Body Size - IGF1R
GG
Chromosome 3

The "A" allele is associated with smaller size.

Citations: Hoopes et al 2012

Body Size - STC2
TT
Chromosome 4

The "A" allele is associated with smaller size.

Citations: Rimbault et al 2013

Body Size - GHR (E195K)
GG
Chromosome 4

The "A" allele is associated with smaller size.

Citations: Rimbault et al 2013

Body Size - GHR (P177L)
CC
Chromosome 4

The "T" allele is associated with smaller size.

Citations: Rimbault et al 2013

Performance

Altitude Adaptation (EPAS1)
GG
Chromosome 10

Confers hypoxia tolerance. Dogs with at least one A allele are more tolerant of high altitude environments. This mutation was originally identified in breeds from high altitude areas such as the Tibetan Mastiff.

Citations: Gou et al 2014

Explore more

Swipe left and right to explore more results, or choose a category below

Health

>
We have tested Ares for over 160 genetic health conditions to alert his owner to potential issues before they strike.

Maternal Haplotype

>
Through the DNA inherited from Ares’s mother we can trace his ancestry back to where dogs and people first became friends. Find out how far Ares’s family has traveled.

Paternal Haplotype

>
The Y-Chromosome is only passed down from father to son. Ares’s DNA includes a story of where his father’s ancestors came from. We’ll show you more about how we categorize his ancestors all based of the science of genetics.

What’s your dog’s story?

Now that you have explored what’s behind Ares find out what your dog’s DNA has to tell you. Embark tells you more about your dog than you ever thought possible. Are you ready? Let’s go!

Through Ares’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A2

Haplotype

A29a

Map

A2

Ares’s Haplogroup

A2 is a very ancient maternal line. Most likely it was one of the major female lines that contributed to the very first domesticated dogs in Central Asia about 15,000 years ago. Some of the line stayed in Central Asia to the present day, and frequently appear as Tibetan Mastiffs and Akitas. Those that escaped the mountains of Central Asia sought out other cold spots, and are now found among Alaskan Malamutes and Siberian Huskies. This lineage is also occasionally found in several common Western breeds, such as German Shepherds and Labrador Retrievers. Curiously, all New Guinea Singing Dogs descend from this line. These are an ancient and very interesting breed found in the mountains of Papua New Guinea. Unfortunately, they are now endangered. They are closely related to the Australian dingo, so you could say its cousins are dingos! This line is also common in village dogs in Southeast and East Asia. Unlike many other lineages, A2 did not spread across the whole world, probably because it did not have the opportunity to hitch its wagon to European colonialism - or because these dogs just prefer hanging out in mountains, tundras, islands, and other hard-to-reach places!

A29a

Ares’s Haplotype

Part of the A2 haplogroup, this haplotype occurs most commonly in Siberian Huskies, Alaskan Malamutes, Labrador Retrievers, and village dogs from Alaska.

Some other Embark dogs with this haplotype:

Dingos commonly possess this haplogroup.

Explore more

Swipe left and right to explore more results, or choose a category below

Health

>
We have tested Ares for over 160 genetic health conditions to alert his owner to potential issues before they strike.

Traits

>
Genes for coat color and type, body size and shape, and other characteristics.

Paternal Haplotype

>
The Y-Chromosome is only passed down from father to son. Ares’s DNA includes a story of where his father’s ancestors came from. We’ll show you more about how we categorize his ancestors all based of the science of genetics.

What’s your dog’s story?

Now that you have explored what’s behind Ares find out what your dog’s DNA has to tell you. Embark tells you more about your dog than you ever thought possible. Are you ready? Let’s go!

Through Ares’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A2b

Haplotype

Hc.2

Map

A2b

Ares’s Haplogroup

A2b appears to have split a few times in succession, which means that some of the Central Asian male ancestors of this lineage went their separate ways before their respective Y chromosomes made their rounds. There is not much diversity in this lineage, meaning that it has only begun to take off recently. Two iconic breeds, the Dachshund and Bloodhound, represent this lineage well. Over half of Rottweilers are A2b, as are the majority of Labrador Retrievers and Cavalier King Charles Spaniels. While A2a is restricted mostly to East Asia, this paternal line is also found among European breeds.

Hc.2

Ares’s Haplotype

Part of the A2b haplogroup, this haplotype has been found in Chinese Shar-pei and village dogs in Papua New Guinea.

Some other Embark dogs with this haplotype:

A2b is found in the Daschund breed.

Explore more

Swipe left and right to explore more results, or choose a category below

Health

>
We have tested Ares for over 160 genetic health conditions to alert his owner to potential issues before they strike.

Traits

>
Genes for coat color and type, body size and shape, and other characteristics.

Maternal Haplotype

>
Through the DNA inherited from Ares’s mother we can trace his ancestry back to where dogs and people first became friends. Find out how far Ares’s family has traveled.

What’s your dog’s story?

Now that you have explored what’s behind Ares find out what your dog’s DNA has to tell you. Embark tells you more about your dog than you ever thought possible. Are you ready? Let’s go!