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Khaleesi inherited one copy of the variant we tested
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Genetic Age
Please note that genetic age is different from calendar age. We can now estimate your dog's calendar age with the Embark Age Test.
The genetic age in this report is an estimation of where your dog is in his or her healthspan. Dogs age at very different rates due to a number of genetic and environmental factors. Body size is a strong genetic influence: for example, a seven year old Great Dane is at the start of his golden years, but a seven year old Pomeranian is just learning what "slow down" means. Just within this example, you can see that the old "one doggie year = seven human years" adage isn’t going to work. And yet, knowing your dog’s age is important: it informs what your dog needs as far as food, frequency of veterinary checkups, and exercise. So how do you best determine how old your dog is?
Embark's genetic age feature calculates how old your dog would be if he or she were aging at an average human rate (using humans in the USA as the baseline). So going back to our Dane/Pom example, we'd estimate a seven year old Great Dane at about 80 years old (senior citizen), but a seven year old Pom would be about 42 (adult). Makes way more sense, right?
Personalized genetic age table for Khaleesi
| Calendar age | Genetic age |
|---|---|
| 1 year | 18 human years |
| 2 years | 25 human years |
| 3 years | 30 human years |
| 4 years | 35 human years |
| 5 years | 40 human years |
| 6 years | 45 human years |
| 7 years | 50 human years |
| 8 years | 55 human years |
| 9 years | 60 human years |
| 10 years | 65 human years |
All we need from you is a calendar age. It's okay if this is an estimation: it is just a starting point. We then factor in your dog's breed composition, information at certain genes that affect size, and their inbreeding coefficient to calculate genetic age. Like in humans, in dogs females tend to live longer than males (so an “80 year old” female dog = 80 year old woman). Exercise and diet also play a role in how long your dog will live. Nevertheless, genetic age is the primary risk factor for numerous diseases in dogs, including cancer, kidney disease, osteoarthritis, cataracts, cardiac disease and cognitive decline. It can help you and your vet know what you should feed your dog, what screenings to get, and other aspects of your dog’s care.
Wolfiness score
How wolfy is my dog?
Most dogs have wolfiness scores of 1% or less. We find populations and breeds with higher scores of 2-4% occasionally, and unique dogs with scores of 5% or above more rarely.
What it means for my dog
Your dog’s Wolfiness Score is not a measure of recent dog-wolf hybridization and does not necessarily indicate that your dog has some recent wolf ancestors. (If your dog has recent wolf ancestors, you will see that in the breed mix report.) Instead, the Wolfiness Score is based on the number of ancient genetic variants your dog has in our unique Wolfiness marker panel. Wolfiness scores up to 10% are almost always due to ancient wolf genes that survived many generations, rather than any recent wolf ancestors. These ancient genes may be a few thousand years old, or may even date back to the original domestication event 15,000 years ago. They are bits of a wild past that survive in your dog!
The science
Your dog’s Wolfiness Score is based on hundreds of markers across the genome where dogs (or almost all of them) are the same, but wolves tend to be different. These markers are thought to be related to "domestication gene sweeps" where early dogs were selected for some trait. Scientists have known about “domestication gene sweeps” for years, but do not yet know why each sweep occurred. By finding rare dogs carrying an ancient variant at a certain marker, we can make associations with behavior, size, metabolism, and development that likely caused these unique signatures of “doggyness” in the genome.
Predicted Adult Weight
How does weight matter?
For people with puppies, you probably want to know how big of a crate to buy or just how big to expect your dog to become. But genetic weight is also useful for people with fully grown dogs. Just like with people, overweight and obese dogs suffer reduced length and quality of life. They can develop chronic health conditions and suffer from limited mobility and other issues. While over half of American dogs are overweight or obese, fewer than 15% of their owners realize it. By comparing your dog’s weight to their genetic predicted weight you have one more piece of information about their ideal weight. With this and other pieces of information like weight history and body condition, you and your veterinarian may want to discuss your dog’s diet, exercise, and weight control plan to give your pup the longest, healthiest life possible.
How do we predict weight?
Our test is the only dog DNA test that provides true genetic size not based just on breed ancestry but based on over a dozen genes known to influence a dog’s weight. It uses the most advanced science to determine your dog’s expected weight based on their sex, the combination of these genes, and breed-specific modifiers.
How accurate is the predicted weight?
Unlike in people, healthy weight in dogs is controlled largely by only a few genes. Our algorithm explains over 85% of the variance in healthy adult weight. However, due to a few as-yet-undiscovered genes and genetic interactions that affect size, this algorithm sometimes misses. Occasionally it misses by a fairly large amount especially when a dog has a breed with an unknown size-influencing gene. If we have missed your dog’s weight, your dog may be a scientific discovery waiting to happen! Please be sure to go to the Research tab and complete the Getting to know your dog survey, where you can answer questions about your dog’s current weight and body shape. This information will inform our ongoing research into the genetics of size and weight in dogs.
Haplotypes
Revealing your dog’s ancient heritage
Haplotypes are particular DNA sequences that are inherited entirely from a dog’s mom (maternal) or dad (paternal).
Because they are inherited whole, your dog and his or her mom share the exact same maternal haplotype. If you have a male dog, your dog and his dad share the exact same paternal haplotype (female dogs don’t inherit paternal haplotypes).
Because most breeds were started with only a few individual dogs, many breeds are dominated by only one or a few haplotypes.
Haplogroups
Revealing your dog’s ancient heritage
Haplogroups are groups of similar DNA sequences (called haplotypes) that are inherited entirely from the mother (maternal) or father (paternal) and don’t get shuffled up like other parts of your dog’s genome.
These groups all originally descend from one male or female wolf, usually one that lived tens of thousands of years ago. Because they are inherited whole and not shuffled like other DNA, they can be used to trace the ancestral routes that dogs took around the globe en route to your home.
Only male dogs have paternal haplogroups because they are determined by the Y chromosome, which only male dogs have. Both males and females have maternal haplogroups, which come from a part of DNA called the mitochondrial DNA.
Breed analysis
Breed analysis is based on comparing your dog’s DNA with the DNA of dogs from over 350 breeds, types and varieties.How are Khaleesi's ancestors represented in her DNA?
All dogs are related and share some DNA. Siblings share lots of their DNA (half of it in fact), cousins share a bit less (an eighth), and so on. Because dog breeds are made up of a closed group of dogs, all dogs in that breed share a lot of their DNA, typically about as much as second cousins, though it varies by breed. Different breeds that are closely related share somewhat less DNA, and dogs from very different breeds share even less DNA (but still much more DNA than either dog shares with a cat).
DNA is inherited in pieces, called chromosomes, that are passed along from parent to offspring. Each generation, these chromosomes are broken up and shuffled a bit in a process known as recombination. So, the length of the segments your dog shares with her ancestors decreases with each generation above her: she shares longer segments with her mom than her grandma, longer segments with her grandma than her great-grandma, and so on.
How does Embark know which breeds are in Khaleesi?
We can use the length of segments Khaleesi shares with our reference dogs to see how many generations it has been since they last shared an ancestor. Long segments of DNA that are identical to known purebred dogs tell Embark's scientists that Khaleesi has, without a doubt, a relative from that breed. By testing over 200,000 genetic markers, we build up her genes one DNA segment at a time, to learn the ancestry with great certainty. Other dog DNA tests look at many fewer genetic markers and have to take a guess at breed ancestry based on that.
What does this mean for Khaleesi's looks and behavior?
Look closely and you'll probably find Khaleesi has some physical and/or behavioral resemblance with her ancestor's breeds. The exact similarity depends on which parts of DNA Khaleesi shares with each breed. Some traits associated with each breed are listed in the Breed & Ancestry section of our website. Embark will tell you even more about Khaleesi's traits soon!
P.S. In a small proportion of cases, we find dogs that don’t share segments with other dogs we have tested, indicating the presence of a rare breed that is not part of our reference panel or possibly a true "village dog" without any purebred relatives at all. In these rare cases we contact the owner to find out more and let them know about their unique dog before they get their results. With this in-depth detective work, we are pushing science forward by identifying genetically unique groups of dogs.
Still have questions?
Let us know with our contact form or by email at howdy@embarkvet.com.
Unresolved? Supermutt?
Yes! Some dogs descend from other dogs that were themselves mixed breed. These other dogs can give small contributions to the ancestry of your dog, so small that they are no longer recognizable as any one particular breed. We call this portion unresolved or “Supermutt” since it confers super powers! Just kidding. But we do think supermutts really are super!
What are “Dogs Like Khaleesi?”
“Dogs Like Khaleesi” are based on the percentage of breeds the two dogs have in common. For example, two dogs that are both 27% Golden Retriever and 73% Poodle will have a score of 100%. Sometimes dogs with high scores look alike, and sometimes they don’t — either way the comparison is based on each dog’s unique DNA.
“Born and raised in Canada! Very intelligent but sometimes too smart for her own good! Is not a fan of doing the trick “Roll Over” and will complain(whining) to get out of it. Indirectly because of this, she has gained the skill of “Singing” and can also make a large range of sounds. She has high energy and is always down for a long walk (although not a fan of running) and loves her humans very much.”
Place of Birth
Toronto, Ontario, Canada
Current Location
Toronto, Ontario, Canada
From
Toronto, Ontario, Canada
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Genetic Breed Result
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Pomeranian
The Pomeranian is a cocky, animated companion with an extroverted personality.
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Health Summary
Khaleesi has one variant that you should let your vet know about.
ALT Activity
Why is this important to your vet?
Khaleesi has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Khaleesi has this genotype, as ALT is often used as an indicator of liver health and Khaleesi is likely to have a lower than average resting ALT activity. As such, an increase in Khaleesi’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.
What is ALT Activity?
Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.
Breed-Relevant Genetic Conditions
5 variants not detected
Methemoglobinemia
Identified in Pomeranians
Variant not detected
Progressive Retinal Atrophy, rcd3
Identified in Pomeranians
Variant not detected
Urate Kidney & Bladder Stones
Identified in Pomeranians
Variant not detected
Oculocutaneous Albinism, OCA
Identified in Pomeranians
Variant not detected
Hereditary Vitamin D-Resistant Rickets
Identified in Pomeranians
Variant not detected
Additional Genetic Conditions
239 variants not detected
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Through Khaleesi’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.
Haplogroup
A1b
Haplotype
A240
A1b
Khaleesi’s Haplogroup
This female lineage was very likely one of the original lineages in the wolves that were first domesticated into dogs in Central Asia about 15,000 years ago. Since then, the lineage has been very successful and travelled the globe! Dogs from this group are found in ancient Bronze Age fossils in the Middle East and southern Europe. By the end of the Bronze Age, it became exceedingly common in Europe. These dogs later became many of the dogs that started some of today's most popular breeds, like German Shepherds, Pugs, Whippets, English Sheepdogs and Miniature Schnauzers. During the period of European colonization, the lineage became even more widespread as European dogs followed their owners to far-flung places like South America and Oceania. It's now found in many popular breeds as well as village dogs across the world!
A240
Khaleesi’s Haplotype
Part of the large A1b haplogroup, this haplotype has been spotted in village dogs in Portugal, Costa Rica, and Brazil. Among the breeds we have seen it in, it occurs most often in Miniature Schnauzers, Pugs, and Maltese. Not confined to small breeds, we also see this haplotype in Pharaoh Hounds and Ibizan Hounds.
Some other Embark dogs with this haplotype:
A1b is the most common haplogroup found in German Shepherds.
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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.
Are you looking for information on the breeds that Khaleesi inherited from her mom and dad? Check out her breed breakdown and family tree.
Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!
Why can’t we show Paternal Haplotype results for female dogs?
All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy.
As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.
Since Khaleesi is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.
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