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“Freya”
Keeper Of The Flame Cova Da Iria

Sussex Spaniel

“Freya is from Poland”

Place of Birth

Poland

Current Location

Knotts Island, North Carolina, USA

From

Poland

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Registration

American Kennel Club (AKC): SS38085702
Microchip: 616093902034712

Genetic Breed Result

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Sussex Spaniel

The Sussex Spaniel is a breed of dog developed in Sussex in southern England. It is a low, compact spaniel and is similar in appearance to the Clumber Spaniel. They can be slow paced, but can have a clownish and energetic temperament.

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Changes to this dog’s profile
  • On 12/27/2022 changed name from "Keysi" to "Keeper Of The Flame Cova Da Iria"

Health Summary

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Freya is at increased risk for one genetic health condition.

And inherited two variants that you should learn more about.

Intervertebral Disc Disease (Type I)

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Freya inherited both copies of the variant we tested

What does this result mean?

Follow-up by our experts indicates that this genetic variant is associated with an increase to Freya’s risk for developing Intervertebral Disc Disease (Type I).

Scientific Basis

Research studies for this variant have been based on dogs of other breeds. While dogs with similar breeds to Freya have not yet been the focus of research studies, our data indicates that Freya is likely to be at increased risk.

Impact on Breeding

While further investigation is warranted to determine the clinical presentation and penetrance in Freya’s breed, we recommend taking this genetic result into account when making breeding decisions.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

Skeletal Dysplasia 2, SD2

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Freya inherited both copies of the variant we tested

What does this result mean?

We do not know whether this increases the risk that Freya will develop Skeletal Dysplasia 2, SD2.

Scientific Basis

Research studies for this variant have been based on dogs of other breeds. Not enough dogs with Freya's breed have been studied to know whether or not this variant will increase Freya's risk of developing this disease.

Impact on Breeding

Research into the clinical impact of this variant is ongoing. We recommend tracking this genetic result and incidence of Skeletal Dysplasia 2, SD2 in your breeding program and related dogs.

What is Skeletal Dysplasia 2, SD2?

A disease of skeletal development, this causes dogs to have abnormally short legs but similar body lengths compared to unaffected dogs.

ALT Activity

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Freya inherited one copy of the variant we tested

Why is this important to your vet?

Freya has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Freya has this genotype, as ALT is often used as an indicator of liver health and Freya is likely to have a lower than average resting ALT activity. As such, an increase in Freya’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Pyruvate Dehydrogenase Deficiency (PDP1, Spaniel Variant)

Identified in Sussex Spaniels

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

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Through Freya’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1b

Haplotype

A414/643

Map

A1b

Keeper Of The Flame Cova Da Iria’s Haplogroup

This female lineage was very likely one of the original lineages in the wolves that were first domesticated into dogs in Central Asia about 15,000 years ago. Since then, the lineage has been very successful and travelled the globe! Dogs from this group are found in ancient Bronze Age fossils in the Middle East and southern Europe. By the end of the Bronze Age, it became exceedingly common in Europe. These dogs later became many of the dogs that started some of today's most popular breeds, like German Shepherds, Pugs, Whippets, English Sheepdogs and Miniature Schnauzers. During the period of European colonization, the lineage became even more widespread as European dogs followed their owners to far-flung places like South America and Oceania. It's now found in many popular breeds as well as village dogs across the world!

A414/643

Keeper Of The Flame Cova Da Iria’s Haplotype

Part of the A1b haplogroup, this haplotype occurs most frequently in the English Springer Spaniels.

A1b is the most common haplogroup found in German Shepherds.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Freya inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Freya is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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