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Keely

Irish Setter

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This dog has been viewed and been given 2 wags

Genetic Breed Result

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Irish Setter

The Irish Setter is a stunning breed that traces its origins all the way back to 18th century Ireland. They were orignally bred for hunting, but now they serve as loyal companions. This is an energetic and sensistive dog that is sure to impress everyone it meets.

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Here’s what Keely’s family tree may have looked like.
While there may be other possible configurations of her family’s relationships, this is the most likely family tree to explain Keely’s breed mix.
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Health Summary

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Keely has one variant that you should let your vet know about.

ALT Activity

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Keely inherited both copies of the variant we tested

Why is this important to your vet?

Keely has two copies of a variant in the GPT gene and is likely to have a lower than average baseline ALT activity. ALT is a commonly used measure of liver health on routine veterinary blood chemistry panels. As such, your veterinarian may want to watch for changes in Keely's ALT activity above their current, healthy, ALT activity. As an increase above Keely’s baseline ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Von Willebrand Disease Type I, Type I vWD (VWF)

Identified in Irish Setters

Canine Leukocyte Adhesion Deficiency Type I, CLAD I (ITGB2, Setter Variant)

Identified in Irish Setters

Progressive Retinal Atrophy, rcd1 (PDE6B Exon 21, Irish Setter Variant)

Identified in Irish Setters

Neuronal Ceroid Lipofuscinosis 8, NCL 8 (CLN8 Exon 2, English Setter Variant)

Identified in Irish Setters

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

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Through Keely’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1e

Haplotype

A320

Map

A1e

Keely’s Haplogroup

This female lineage likely stems from some of the original Central Asian wolves that were domesticated into modern dogs starting about 15,000 years ago. It seemed to be a fairly rare dog line for most of dog history until the past 300 years, when the lineage seemed to “explode” out and spread quickly. What really separates this group from the pack is its presence in Alaskan village dogs and Samoyeds. It is possible that this was an indigenous lineage brought to the Americas from Siberia when people were first starting to make that trip themselves! We see this lineage pop up in overwhelming numbers of Irish Wolfhounds, and it also occurs frequently in popular large breeds like Bernese Mountain Dogs, Saint Bernards and Great Danes. Shetland Sheepdogs are also common members of this maternal line, and we see it a lot in Boxers, too. Though it may be all mixed up with European dogs thanks to recent breeding events, its origins in the Americas makes it a very exciting lineage for sure!

A320

Keely’s Haplotype

Part of the large A1e haplogroup, this haplotype occurs most commonly in Irish Setters. It’s a rare find!

Irish Wolfhounds are a consistent carrier of A1e.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Keely inherited from her mom and dad? Check out her breed breakdown and family tree.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Keely is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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