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Kali

Mixed Ancestry

No bio has been provided yet

Place of Birth

Spartanburg, SC, USA

Current Location

Philadelphia, Pennsylvania, USA

From

Malvern, PA, USA

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Genetic Breed Result

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Embark Supermutt analysis

What’s in that Supermutt? There may be small amounts of DNA from these distant ancestors:

Siberian Husky

Bred initially in Northern Siberia, the Siberian Husky is a medium-sized working dog who is quick and light on their feet. Their moderately compact and well furred body, erect ears and brush tail suggest their Northern heritage. Huskies are very active and energetic and are known for being long distance sled dogs.

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Boston Terrier

Boston Terriers are lively, intelligent and friendly. Although a small dog, they are strong and sturdy. Owners of this breed find them to be As the breed's name implies, the Boston Terrier originated in the city of Boston in the late 19th century. They're sometimes referred to be their nickname of the "American gentleman" because of their tuxedo-like coat.

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Pug

The Pug is a breed of dog with a wrinkly, short-muzzled face and curled tail. Pugs are known for being sociable and gentle companion dogs.

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American Pit Bull Terrier

The American Pit Bull Terrier originated in the British Isles and descends from the Mastiff-type dogs introduced to England in antiquity. The breed was brought over to the United States by English immigrants in the 1800s, and quickly became one of the most popular and widespread breeds there.

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Cocker Spaniel

Cocker Spaniels are handsome and intelligent hunting dogs that are also well-suited to life as a loving family pet.

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Beagle

The Beagle is a scent hound and a great family pet. They are known for being affectionate and having loud voices.

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Labrador Retriever

The Labrador Retriever was bred for hunting and excelled in retrieving game after it was shot down. Known for its gentle disposition and loyalty, the Labrador Retriever has become a favorite of families and breeders alike.

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Dogs Like Kali

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Discover dogs who share a similar breed mix to Kali. A higher score means the two dogs have more of their breed mix in common. A score of 100% means they share the exact same breed mix!

Click or tap on a pic to learn more about each dog and see an in-depth comparison of their DNA, breeds, and more.

DNA Breed Origins

Breed colors:
Siberian Husky
Boston Terrier
Pug
American Pit Bull Terrier
Cocker Spaniel
Beagle
Labrador Retriever
Supermutt

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Here’s what Kali’s family tree may have looked like.
Kali
Family Tree From Embark PARENTS GRANDPARENTS GREAT GRANDPARENTS Mixed Siberian Husky mix Boston Terrier / Pug mix American Pit Bull Terrier / Cocker Spaniel mix Siberian Husky Labrador Retriever mix Boston Terrier Pug American Pit Bull Terrier mix Cocker Spaniel mix Siberian Husky Siberian Husky Labrador Retriever mix Mixed
While there may be other possible configurations of her family’s relationships, this is the most likely family tree to explain Kali’s breed mix.
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Health Summary

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Kali is at increased risk for one genetic health condition.

And inherited three variants that you should learn more about.

Intervertebral Disc Disease (Type I)

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Kali inherited one copy of the variant we tested

How to interpret this result

Kali has one copy of an FGF4 retrogene on chromosome 12. In some breeds such as Beagles, Cocker Spaniels, and Dachshunds (among others) this variant is found in nearly all dogs. While those breeds are known to have an elevated risk of IVDD, many dogs in those breeds never develop IVDD. For mixed breed dogs and purebreds of other breeds where this variant is not as common, risk for Type I IVDD is greater for individuals with this variant than for similar dogs.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

Urate Kidney & Bladder Stones

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Kali inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Kali’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Kali is unlikely to develop this condition due to this variant because she only has one copy of the variant.

What is Urate Kidney & Bladder Stones?

This condition causes kidney and bladder stones composed of urate. In most dogs, uric acid is converted to allantoin, an inert substance that is then excreted in the urine. Dogs with HUU have defects in the pathway that converts uric acid to allantoin. As such, uric acid builds up, crystallizes and forms urate stones in the kidney and bladder. Uric acid is an intermediate of purine metabolism. While hyperuricemia in other species (including humans) can lead to painful conditions such as gout, dogs do not develop systemic signs of hyperuricemia.

Collie Eye Anomaly

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Kali inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Kali’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Kali is unlikely to develop this condition due to this variant because she only has one copy of the variant.

What is Collie Eye Anomaly?

Named for its high prevalence in Collie dogs, Collie Eye Anomaly (CEA) is more correctly termed choroidal hypoplasia. The choroid anchors the retina to the underlying structures and supplies it with oxygen and nourishment. CEA is a developmental disease of the choroid.

ALT Activity

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Kali inherited one copy of the variant we tested

Why is this important to your vet?

Kali has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Kali has this genotype, as ALT is often used as an indicator of liver health and Kali is likely to have a lower than average resting ALT activity. As such, an increase in Kali’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Factor VII Deficiency

Identified in Beagles

Canine Elliptocytosis

Identified in Labrador Retrievers

May-Hegglin Anomaly

Identified in Pugs

Pyruvate Kinase Deficiency

Identified in Labrador Retrievers

Pyruvate Kinase Deficiency

Identified in Pugs

Pyruvate Kinase Deficiency

Identified in Beagles

Progressive Retinal Atrophy, prcd

Identified in Cocker Spaniels and Labrador Retrievers

Golden Retriever Progressive Retinal Atrophy 2, GR-PRA2

Identified in Labrador Retrievers

Progressive Retinal Atrophy, crd1

Identified in American Pit Bull Terriers

Progressive Retinal Atrophy, crd2

Identified in American Pit Bull Terriers

Progressive Retinal Atrophy, crd4/cord1

Identified in Beagles and Labrador Retrievers

X-Linked Progressive Retinal Atrophy 1, XL-PRA1

Identified in Siberian Huskies

Day Blindness

Identified in Labrador Retrievers

Primary Open Angle Glaucoma

Identified in Beagles

Macular Corneal Dystrophy, MCD

Identified in Labrador Retrievers

Familial Nephropathy

Identified in Cocker Spaniels

Glycogen storage disease Type VII, Phosphofructokinase Deficiency, PFK Deficiency

Identified in Cocker Spaniels

Neuronal Ceroid Lipofuscinosis, Cerebellar Ataxia, NCL4A

Identified in American Pit Bull Terriers

GM1 Gangliosidosis

Identified in Siberian Huskies

Alexander Disease

Identified in Labrador Retrievers

Neonatal Cerebellar Cortical Degeneration

Identified in Beagles

Degenerative Myelopathy, DM

Identified in Labrador Retrievers, Pugs, and more

L-2-Hydroxyglutaricaciduria, L2HGA

Identified in American Pit Bull Terriers

Narcolepsy

Identified in Labrador Retrievers

Acral Mutilation Syndrome

Identified in Cocker Spaniels

Limb Girdle Muscular Dystrophy

Identified in Boston Terriers

Centronuclear Myopathy, CNM

Identified in Labrador Retrievers

Exercise-Induced Collapse, EIC

Identified in Cocker Spaniels and Labrador Retrievers

X-Linked Myotubular Myopathy

Identified in Labrador Retrievers

Hypocatalasia, Acatalasemia

Identified in Beagles

Cobalamin Malabsorption

Identified in Beagles

Congenital Myasthenic Syndrome, CMS

Identified in Labrador Retrievers

Hereditary Nasal Parakeratosis, HNPK

Identified in Labrador Retrievers

Musladin-Lueke Syndrome, MLS

Identified in Beagles

Osteogenesis Imperfecta

Identified in Beagles

Skeletal Dysplasia 2, SD2

Identified in Labrador Retrievers

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Base Coat Color

Base Coat Color

Coat Color Modifiers

Coat Color Modifiers

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Kali’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

B1

Haplotype

B81

Map

B1

Kali’s Haplogroup

B1 is the second most common maternal lineage in breeds of European or American origin. It is the female line of the majority of Golden Retrievers, Basset Hounds, and Shih Tzus, and about half of Beagles, Pekingese and Toy Poodles. This lineage is also somewhat common among village dogs that carry distinct ancestry from these breeds. We know this is a result of B1 dogs being common amongst the European dogs that their conquering owners brought around the world, because nowhere on earth is it a very common lineage in village dogs. It even enables us to trace the path of (human) colonization: Because most Bichons are B1 and Bichons are popular in Spanish culture, B1 is now fairly common among village dogs in Latin America.

B81

Kali’s Haplotype

Part of the large B1 haplogroup, this haplotype occurs most frequently in Shih Tzus, Chihuahuas, and Poodles.

The B1 haplogroup can be found in village dogs like the Peruvian Village Dog, pictured above.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Kali inherited from her mom and dad? Check out her breed breakdown and family tree.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Kali is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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