Dunkin’ inherited one copy of the variant we tested
No Dogs Available
It looks like you don’t have any dogs on your account yet. Activate a kit now!
No bio has been provided yet
This dog has been viewed and been given 0 wags
Start a conversation! Message this dog’s owner.
Explore
Health Summary
Dunkin’ inherited one variant that you should learn more about.
And two variants that you should tell your vet about.
Degenerative Myelopathy, DM
What does this result mean?
This variant should not impact Dunkin’’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Dunkin’ is unlikely to develop this condition due to this variant because he only has one copy of the variant.
Impact on Breeding
Your dog carries this variant and will pass it on to ~50% of his offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.
What is Degenerative Myelopathy, DM?
The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.
ALT Activity
Dunkin’ inherited one copy of the variant we tested
Why is this important to your vet?
Dunkin’ has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Dunkin’ has this genotype, as ALT is often used as an indicator of liver health and Dunkin’ is likely to have a lower than average resting ALT activity. As such, an increase in Dunkin’’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.
What is ALT Activity?
Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.
Copper Toxicosis (Attenuating)
Dunkin’ inherited one copy of the variant we tested
Why is this important to your vet?
Dunkin’ has a genotype at the ATP7A gene that modifies and may help mitigate some of the symptoms from dogs with variants at ATP7B. This variant is not associated with an increased risk of any disease. As this variant resides on the X- chromosome, male dogs with one copy of the variant are better protected from copper accumulation due to the ATP7B variant than female dogs with one copy of the variant.
What is Copper Toxicosis (Attenuating)?
The ATP7A variant is considered beneficial and may be best described as a helpful modifier of the harmful copper toxicosis variant ATP7B. The ATP7A variant may help mitigate some of the symptoms of dogs with variants at ATP7B. Dogs with the ATP7A variant have not been observed to have any beneficial or harmful complications if they have two copies of the normal ATP7B variant.
Breed-Relevant Genetic Conditions
Multiple Drug Sensitivity (ABCB1)
Identified in Australian Shepherds
Variant not detected
Von Willebrand Disease Type I, Type I vWD (VWF)
Identified in Bernese Mountain Dogs, Standard Poodles, and more
Variant not detected
Progressive Retinal Atrophy, prcd (PRCD Exon 1)
Identified in Australian Shepherds, Standard Poodles, and more
Variant not detected
Collie Eye Anomaly (NHEJ1)
Identified in Australian Shepherds
Variant not detected
Day Blindness (CNGB3 Deletion, Alaskan Malamute Variant)
Identified in Australian Shepherds
Variant not detected
Canine Multifocal Retinopathy, cmr1 (BEST1 Exon 2)
Identified in Australian Shepherds
Variant not detected
Hereditary Cataracts (HSF4 Exon 9, Australian Shepherd Variant)
Identified in Australian Shepherds
Variant not detected
Urate Kidney & Bladder Stones (SLC2A9)
Identified in Australian Shepherds
Variant not detected
Neuronal Ceroid Lipofuscinosis 6, NCL 6 (CLN6 Exon 7, Australian Shepherd Variant)
Identified in Australian Shepherds
Variant not detected
Neuronal Ceroid Lipofuscinosis 8, NCL 8 (CLN8, Australian Shepherd Variant)
Identified in Australian Shepherds
Variant not detected
GM2 Gangliosidosis (HEXB, Poodle Variant)
Identified in Standard Poodles and Small Poodles
Variant not detected
Neonatal Encephalopathy with Seizures, NEWS (ATF2)
Identified in Standard Poodles and Small Poodles
Variant not detected
Osteochondrodysplasia (SLC13A1, Poodle Variant)
Identified in Standard Poodles and Small Poodles
Variant not detected
Craniomandibular Osteopathy, CMO (SLC37A2)
Identified in Australian Shepherds
Variant not detected
Intervertebral Disc Disease (Type I) (FGF4 retrogene - CFA12)
Identified in Standard Poodles and Small Poodles
Variant not detected
Junctional Epidermolysis Bullosa (LAMB3 Exon 11, Australian Shepherd Variant)
Identified in Australian Shepherds
Variant not detected
Hereditary Ataxia (PNPLA8, Australian Shepherd Variant)
Identified in Australian Shepherds
Variant not detected
Primary Ciliary Dyskinesia, PCD (STK36, Australian Shepherd Variant)
Identified in Australian Shepherds
Variant not detected
Additional Genetic Conditions
Explore
What is a linkage test?
DNA sequences that are close together on a chromosome tend to be inherited together. Because of this, we can use genetic variation surrounding a specific variant (i.e. "linked" to it) to infer the presence or absence of a variant that is associated with a health condition or trait.
Linkage tests are not as predictive of your dog’s true genotype as direct assays, which we use on most other genetic conditions we test for.
Traits
Explore the genetics behind your dog’s appearance and size.
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Coat Color
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Other Coat Traits
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Other Body Features
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Body Size
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.