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Jet

Curly-Coated Retriever

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“Jet is an AKC registered Curly Coated Retriever. He is the first Curly I have owned.”

Place of Birth

California, USA

Current Location

Oregon, Wisconsin, USA

From

California, USA

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Registration

American Kennel Club (AKC): SS16975005

Genetic Breed Result

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Curly-Coated Retriever

Curly-Coated Retrievers are intelligent, hard-working, lovable dogs. These guys are believed to be the first retriever breed. Despite being the original, Curlys are now one of the least common retrievers.

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Breed Reveal Video

Our algorithms predict this is the most likely family tree to explain Jet’s breed mix, but this family tree may not be the only possible one.

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Health Summary

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Jet is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Exercise-Induced Collapse, EIC

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Jet inherited both copies of the variant we tested

How to interpret this result

Jet has two copies of a variant in the DNM1 gene and is at risk for developing EIC. Please note that this variant is known to have incomplete penetrance; that is, a number of dogs who carry two copies of this variant do not exhibit signs of the disease, suggesting that other genetic and environmental factors are required for animals to display signs of EIC. Please consult your veterinarian to discuss further diagnostics, monitoring, and care for Jet.

What is Exercise-Induced Collapse, EIC?

EIC has been linked to a mutation in the DNM1 gene, which codes for the protein dynamin. In the neuron, dynamin trucks neurotransmitter-filled vesicles from the cell body, where they are generated, to the dendrites. It is hypothesized in dogs affected with EIC, the mutation in DNM1 disrupts efficient neurotransmitter release, leading to a cessation in signalling and EIC.

ALT Activity

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Jet inherited one copy of the variant we tested

Why is this important to your vet?

Jet has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Jet has this genotype, as ALT is often used as an indicator of liver health and Jet is likely to have a lower than average resting ALT activity. As such, an increase in Jet’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Progressive Retinal Atrophy, crd4/cord1

Identified in Curly-Coated Retrievers

Glycogen Storage Disease Type IIIA, GSD IIIA

Identified in Curly-Coated Retrievers

Additional Genetic Conditions

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Explore the genetics behind your dog’s appearance and size.

Base Coat Color

Base Coat Color

Coat Color Modifiers

Coat Color Modifiers

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Jet’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1e

Haplotype

A437

Map

A1e

Jet’s Haplogroup

This female lineage likely stems from some of the original Central Asian wolves that were domesticated into modern dogs starting about 15,000 years ago. It seemed to be a fairly rare dog line for most of dog history until the past 300 years, when the lineage seemed to “explode” out and spread quickly. What really separates this group from the pack is its presence in Alaskan village dogs and Samoyeds. It is possible that this was an indigenous lineage brought to the Americas from Siberia when people were first starting to make that trip themselves! We see this lineage pop up in overwhelming numbers of Irish Wolfhounds, and it also occurs frequently in popular large breeds like Bernese Mountain Dogs, Saint Bernards and Great Danes. Shetland Sheepdogs are also common members of this maternal line, and we see it a lot in Boxers, too. Though it may be all mixed up with European dogs thanks to recent breeding events, its origins in the Americas makes it a very exciting lineage for sure!

A437

Jet’s Haplotype

Part of the A1e haplogroup, the A437 haplotype occurs most commonly in Brussels Griffons, Armenian Gamprs and Russell-type Terriers. We've also spotted it in East Asian Village Dogs, Middle Eastern Village Dogs and American Village Dogs.

Some other Embark dogs with this haplotype:

Irish Wolfhounds are a consistent carrier of A1e.

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Through Jet’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A2b

Haplotype

Hc.17

Map

A2b

Jet’s Haplogroup

A2b appears to have split a few times in succession, which means that some of the Central Asian male ancestors of this lineage went their separate ways before their respective Y chromosomes made their rounds. There is not much diversity in this lineage, meaning that it has only begun to take off recently. Two iconic breeds, the Dachshund and Bloodhound, represent this lineage well. Over half of Rottweilers are A2b, as are the majority of Labrador Retrievers and Cavalier King Charles Spaniels. While A2a is restricted mostly to East Asia, this paternal line is also found among European breeds.

Hc.17

Jet’s Haplotype

Part of the A2b haplogroup, this haplotype occurs most frequently in mixed breed dogs.

Some other Embark dogs with this haplotype:

A2b is found in the Daschund breed.

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