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Jax

Mixed Ancestry

“He is very passionate about bitework!”

Current Location

Nederland

From

Belgium

This dog has been viewed and been given 1 wag

Genetic Breed Result

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Belgian Malinois

The Belgian Malinois is an impressive working dog. These guys have become a staple within the military and the police force due to their intelligence and drive. They can make wonderful companions as long as they are thoroughly exercised.

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Dutch Shepherd

The Dutch Shepherd is a herding dog of Dutch origin. They were used by shepherds and farmers who needed a versatile dog, with few demands, and a dog that was able to adapt to a harsh and meager existence.

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DNA Breed Origins

Breed colors:
Belgian Malinois
Dutch Shepherd

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Health Summary

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Jax inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Urate Kidney & Bladder Stones

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Jax inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Jax’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Jax is unlikely to develop this condition due to this variant because he only has one copy of the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of his offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Urate Kidney & Bladder Stones?

This condition causes kidney and bladder stones composed of urate. In most dogs, uric acid is converted to allantoin, an inert substance that is then excreted in the urine. Dogs with HUU have defects in the pathway that converts uric acid to allantoin. As such, uric acid builds up, crystallizes and forms urate stones in the kidney and bladder. Uric acid is an intermediate of purine metabolism. While hyperuricemia in other species (including humans) can lead to painful conditions such as gout, dogs do not develop systemic signs of hyperuricemia.

ALT Activity

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Jax inherited one copy of the variant we tested

Why is this important to your vet?

Jax has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Jax has this genotype, as ALT is often used as an indicator of liver health and Jax is likely to have a lower than average resting ALT activity. As such, an increase in Jax’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Von Willebrand Disease Type I, Type I vWD (VWF)

Identified in Dutch Shepherds

Mucopolysaccharidosis Type VII, Sly Syndrome, MPS VII (GUSB Exon 3, German Shepherd Variant)

Identified in Belgian Malinois and Dutch Shepherds

Spongy Degeneration with Cerebellar Ataxia 1 (KCNJ10)

Identified in Belgian Malinois and Dutch Shepherds

Spongy Degeneration with Cerebellar Ataxia 2 (ATP1B2)

Identified in Belgian Malinois and Dutch Shepherds

Additional Genetic Conditions

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Through Jax’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

B1

Haplotype

B57

Map

B1

Jax’s Haplogroup

B1 is the second most common maternal lineage in breeds of European or American origin. It is the female line of the majority of Golden Retrievers, Basset Hounds, and Shih Tzus, and about half of Beagles, Pekingese and Toy Poodles. This lineage is also somewhat common among village dogs that carry distinct ancestry from these breeds. We know this is a result of B1 dogs being common amongst the European dogs that their conquering owners brought around the world, because nowhere on earth is it a very common lineage in village dogs. It even enables us to trace the path of (human) colonization: Because most Bichons are B1 and Bichons are popular in Spanish culture, B1 is now fairly common among village dogs in Latin America.

B57

Jax’s Haplotype

Part of the large B1 haplogroup, we have detected this haplotype in Belgian Tervurens, Belgian Malinois, Schipperkes, and village dogs in the Democratic Republic of the Congo.

The B1 haplogroup can be found in village dogs like the Peruvian Village Dog, pictured above.

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Through Jax’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

H1a.56

Map

A1a

Jax’s Haplogroup

Some of the wolves that became the original dogs in Central Asia around 15,000 years ago came from this long and distinguished line of male dogs. After domestication, they followed their humans from Asia to Europe and then didn't stop there. They took root in Europe, eventually becoming the dogs that founded the Vizsla breed 1,000 years ago. The Vizsla is a Central European hunting dog, and all male Vizslas descend from this line. During the Age of Exploration, like their owners, these pooches went by the philosophy, "Have sail, will travel!" From the windy plains of Patagonia to the snug and homey towns of the American Midwest, the beaches of a Pacific paradise, and the broad expanse of the Australian outback, these dogs followed their masters to the outposts of empires. Whether through good fortune or superior genetics, dogs from the A1a lineage traveled the globe and took root across the world. Now you find village dogs from this line frolicking on Polynesian beaches, hanging out in villages across the Americas, and scavenging throughout Old World settlements. You can also find this "prince of patrilineages" in breeds as different as German Shepherds, Golden Retrievers, Pugs, Border Collies, Scottish Terriers, and Irish Wolfhounds. No male wolf line has been as successful as the A1a line!

H1a.56

Jax’s Haplotype

Part of the A1a haplogroup, the H1a.56 haplotype occurs most commonly in Belgian Malinois. It's a rare find!

Dogs with A1a lineage travelled during European Colonial times.

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