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“Creature”
Iron Sights Creature

Mixed Ancestry

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Place of Birth

Florida, USA

Current Location

Tennessee, USA

From

Florida, USA

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Genetic Breed Result

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Dutch Shepherd

The Dutch Shepherd is a herding dog of Dutch origin. They were used by shepherds and farmers who needed a versatile dog, with few demands, and a dog that was able to adapt to a harsh and meager existence.

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Belgian Malinois

The Belgian Malinois is an impressive working dog. These guys have become a staple within the military and the police force due to their intelligence and drive. They can make wonderful companions as long as they are thoroughly exercised.

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DNA Breed Origins

Breed colors:
Dutch Shepherd
Belgian Malinois

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Health Summary

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Creature inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Urate Kidney & Bladder Stones

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Creature inherited one copy of the variant we tested

What does this result mean?

Because this variant is inherited in an autosomal recessive manner (meaning dogs need two copies of the variant to develop the disease), Creature is unlikely to develop this condition due to the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Urate Kidney & Bladder Stones?

This condition causes kidney and bladder stones composed of urate. In most dogs, uric acid is converted to allantoin, an inert substance that is then excreted in the urine. Dogs with HUU have defects in the pathway that converts uric acid to allantoin. As such, uric acid builds up, crystallizes and forms urate stones in the kidney and bladder. Uric acid is an intermediate of purine metabolism. While hyperuricemia in other species (including humans) can lead to painful conditions such as gout, dogs do not develop systemic signs of hyperuricemia.

ALT Activity

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Creature inherited one copy of the variant we tested

Why is this important to your vet?

Creature has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Creature has this genotype, as ALT is often used as an indicator of liver health and Creature is likely to have a lower than average resting ALT activity. As such, an increase in Creature’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Von Willebrand Disease Type I, Type I vWD (VWF)

Identified in Dutch Shepherds

Mucopolysaccharidosis Type VII, Sly Syndrome, MPS VII (GUSB Exon 3, German Shepherd Variant)

Identified in Belgian Malinois and Dutch Shepherds

Spongy Degeneration with Cerebellar Ataxia 1 (KCNJ10)

Identified in Belgian Malinois and Dutch Shepherds

Spongy Degeneration with Cerebellar Ataxia 2 (ATP1B2)

Identified in Belgian Malinois and Dutch Shepherds

Cardiomyopathy and Juvenile Mortality (YARS2)

Identified in Belgian Malinois

Inflammatory Myopathy (SLC25A12)

Identified in Dutch Shepherds

Additional Genetic Conditions

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Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Creature’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

C1

Haplotype

C37

Map

C1

Iron Sights Creature’s Haplogroup

Congratulations, C1 is a very exotic female lineage! It is more closely associated with maternal lineages found in wolves, foxes and jackals than with other dog lineages. So it seems dogs in this group have a common male dog ancestor who, many thousands of years ago, mated with a female wolf! This is not a common lineage in any breed, though a good number of German Shepherds and Doberman Pinchers are C1. It is also found in breeds as diverse as Peruvian Inca Orchids and Pekingese; it is rarely found amongst Labrador Retrievers, Border Collies, Siberian Huskies, or Cocker Spaniels. Despite its fascinating origins, it is widely distributed around the globe, and even shows up frequently among Peruvian village dogs. It almost certainly survived at low frequency in Europe for millennia and then was dispersed outside of Europe by colonialism, though not as successfully as some other lineages.

C37

Iron Sights Creature’s Haplotype

Part of the C1 haplogroup, this haplotype occurs most frequently in German Shepherd Dogs, Siberian Huskies, and English Cocker Spaniels.

Some other Embark dogs with this haplotype:

The C1 maternal line is commonly found in Jackals.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Creature inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Creature is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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