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Indie

Dalmatian

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Current Location

Wisconsin, USA

This dog has been viewed and been given 27 wags

Genetic Breed Result

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Dalmatian

Best known as the star of Disney’s 101 Dalmatians, this sleek and athletic dog breed has a history that goes back several hundred years. He started out as a coach dog but has also served in many other capacities, including hunter, firehouse dog, and circus performer. As charming in life as in film, he goes from gallant to goofy to gallant again in the blink of an eye, and loves to be a part of everything his family does.

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Here’s what Indie’s family tree may have looked like.
While there may be other possible configurations of her family’s relationships, this is the most likely family tree to explain Indie’s breed mix.
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Health Summary

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Indie is at increased risk for one genetic health condition.

And inherited two variants that you should learn more about.

Urate Kidney & Bladder Stones

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Indie inherited both copies of the variant we tested

How to interpret this result

Indie has two copies of a variant in the SLC2A9 gene and is at risk for developing HUU. If you notice Indie straining to urinate, producing urine tinged with blood, or not producing any urine at all, please seek veterinary care immediately; these are signs of urinary obstruction secondary to urolithiasis and could be life threatening.

What is Urate Kidney & Bladder Stones?

This condition causes kidney and bladder stones composed of urate. In most dogs, uric acid is converted to allantoin, an inert substance that is then excreted in the urine. Dogs with HUU have defects in the pathway that converts uric acid to allantoin. As such, uric acid builds up, crystallizes and forms urate stones in the kidney and bladder. Uric acid is an intermediate of purine metabolism. While hyperuricemia in other species (including humans) can lead to painful conditions such as gout, dogs do not develop systemic signs of hyperuricemia.

Degenerative Myelopathy, DM

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Indie inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Indie’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Indie is unlikely to develop this condition due to this variant because she only has one copy of the variant.

What is Degenerative Myelopathy, DM?

The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.

ALT Activity

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Indie inherited one copy of the variant we tested

Why is this important to your vet?

Indie has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Indie has this genotype, as ALT is often used as an indicator of liver health and Indie is likely to have a lower than average resting ALT activity. As such, an increase in Indie’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Base Coat Color

Base Coat Color

Coat Color Modifiers

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Other Coat Traits

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Other Body Features

Other Body Features

Body Size

Body Size

Performance

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Through Indie’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

A381

Map

A1a

Indie’s Haplogroup

A1a is the most common maternal lineage among Western dogs. This lineage traveled from the site of dog domestication in Central Asia to Europe along with an early dog expansion perhaps 10,000 years ago. It hung around in European village dogs for many millennia. Then, about 300 years ago, some of the prized females in the line were chosen as the founding dogs for several dog breeds. That set in motion a huge expansion of this lineage. It's now the maternal lineage of the overwhelming majority of Mastiffs, Labrador Retrievers and Gordon Setters. About half of Boxers and less than half of Shar-Pei dogs descend from the A1a line. It is also common across the world among village dogs, a legacy of European colonialism.

A381

Indie’s Haplotype

Part of the large A1a haplogroup, this haplotype occurs most frequently in German Shepherd Dogs, Doberman Pinschers, and Dachshunds.

Shar Pei dogs think A1a is the coolest!

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Indie inherited from her mom and dad? Check out her breed breakdown and family tree.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Indie is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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