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“River”
I Birbanti Sul Divano Francesca

Lagotto Romagnolo

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Place of Birth

Poland

Current Location

Lake City, Michigan, USA

From

Poland

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Registration

American Kennel Club (AKC): SS16481501

Genetic Breed Result

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Lagotto Romagnolo

Lagotto Romagnolos are an Italian breed of dog from the Romagna region of Italy. Sporting curly hair and charming faces, they were originally bred as hunting dogs during the Medieval Period; however, today they are mostly kept as pets and as a different kind of hunting dog—Lagotto Romagnolos are expert truffle dogs. Their wonderful sense of smell makes them a great candidate for finding and unearthing truffles, rare and expensive mushrooms that are considered culinary delicacies.

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Health Summary

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River inherited one variant that you should learn more about.

Lagotto Storage Disease

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River inherited one copy of the variant we tested

What does this result mean?

This result should not impact River’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring.

What is Lagotto Storage Disease?

This form of lysosomal storage disease arises from a defect in the enzyme ATG4D, which plays a large role in the autophagy pathway. Autophagy describes the process by which the cell recycles damaged or malfunctioning parts of itself including old transport vesicles, organelles, and macromolecules. Loss of ATG4D stops the autophagy pathway in its tracks, causing cellular accumulation of old parts and eventual cellular malfunction and death.

Breed-Relevant Genetic Conditions

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Urate Kidney & Bladder Stones (SLC2A9)

Identified in Lagotto Romagnolos

Juvenile Epilepsy (LGI2)

Identified in Lagotto Romagnolos

Additional Genetic Conditions

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Clinical Tools

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

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Body Size

Body Size

Performance

Performance

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Through River’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1e

Haplotype

A234

Map

A1e

I Birbanti Sul Divano Francesca’s Haplogroup

This female lineage likely stems from some of the original Central Asian wolves that were domesticated into modern dogs starting about 15,000 years ago. It seemed to be a fairly rare dog line for most of dog history until the past 300 years, when the lineage seemed to “explode” out and spread quickly. What really separates this group from the pack is its presence in Alaskan village dogs and Samoyeds. It is possible that this was an indigenous lineage brought to the Americas from Siberia when people were first starting to make that trip themselves! We see this lineage pop up in overwhelming numbers of Irish Wolfhounds, and it also occurs frequently in popular large breeds like Bernese Mountain Dogs, Saint Bernards and Great Danes. Shetland Sheepdogs are also common members of this maternal line, and we see it a lot in Boxers, too. Though it may be all mixed up with European dogs thanks to recent breeding events, its origins in the Americas makes it a very exciting lineage for sure!

A234

I Birbanti Sul Divano Francesca’s Haplotype

Part of the large A1e haplogroup, this haplotype occurs in village dogs in South America, South Asia, and into the South Pacific. Among breeds, we see it in highest frequency among Vizslas, Boxers, and Yorkshire Terriers.

Some other Embark dogs with this haplotype:

Irish Wolfhounds are a consistent carrier of A1e.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that River inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since River is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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