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“Hugo”
Hugo MFK

Siberian Husky

“When Hugo sees anyone that he’s excited to see, he tilts his head back and screams like a woman being murdered.”

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Registration

American Kennel Club (AKC): WA58899602

Genetic Breed Result

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Siberian Husky

Bred initially in Northern Siberia, the Siberian Husky is a medium-sized working dog who is quick and light on their feet. Their moderately compact and well furred body, erect ears and brush tail suggest their Northern heritage. Huskies are very active and energetic and are known for being long distance sled dogs.

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Health Summary

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Hugo has one variant that you should let your vet know about.

ALT Activity

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Hugo inherited both copies of the variant we tested

Why is this important to your vet?

Hugo has two copies of a variant in the GPT gene and is likely to have a lower than average baseline ALT activity. ALT is a commonly used measure of liver health on routine veterinary blood chemistry panels. As such, your veterinarian may want to watch for changes in Hugo's ALT activity above their current, healthy, ALT activity. As an increase above Hugo’s baseline ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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GM1 Gangliosidosis (GLB1 Exon 15, Alaskan Husky Variant)

Identified in Siberian Huskies

Degenerative Myelopathy, DM (SOD1A)

Identified in Siberian Huskies

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Hugo’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1e

Haplotype

A241

Map

A1e

Hugo MFK’s Haplogroup

This female lineage likely stems from some of the original Central Asian wolves that were domesticated into modern dogs starting about 15,000 years ago. It seemed to be a fairly rare dog line for most of dog history until the past 300 years, when the lineage seemed to “explode” out and spread quickly. What really separates this group from the pack is its presence in Alaskan village dogs and Samoyeds. It is possible that this was an indigenous lineage brought to the Americas from Siberia when people were first starting to make that trip themselves! We see this lineage pop up in overwhelming numbers of Irish Wolfhounds, and it also occurs frequently in popular large breeds like Bernese Mountain Dogs, Saint Bernards and Great Danes. Shetland Sheepdogs are also common members of this maternal line, and we see it a lot in Boxers, too. Though it may be all mixed up with European dogs thanks to recent breeding events, its origins in the Americas makes it a very exciting lineage for sure!

A241

Hugo MFK’s Haplotype

Part of the large A1e haplogroup, this haplotype occurs most commonly in village dogs up in Alaska.

Irish Wolfhounds are a consistent carrier of A1e.

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Through Hugo’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A

Haplotype

Hc.1

Map

A

Hugo MFK’s Haplogroup

A is the distant relative of some of the most numerous paternal lineages in the world. Characterized by a single sub-lineage, this is a rare and interesting paternal line! The A line is found most commonly in Siberian Huskies and in Alaskan village dogs. It seems plausible that this paternal lineage diverged within the last 10,000 years from a group arriving with the first Arctic explorers. The recent ancestors of dogs with this lineage actually allowed humans to survive in some of the most forbidding conditions on the face of the earth!

Hc.1

Hugo MFK’s Haplotype

The lone member of the A haplogroup, this haplotype occurs most commonly in Siberian Huskies and village dogs from Alaska.

Siberian Huskys are the only breed to have the A haplogroup.

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