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Hiro

“Hiro is a rescue from WA state - with 7 siblings.”

Place of Birth
Washington, USA
Current Location
Chesnee, South Carolina, USA
From
Black Mountain, NC, USA

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Genetic Breed Result

Learn how it’s done
37.7% German Shepherd Dog
30.5% Gray Wolf
25.4% Alaskan Malamute
6.4% Siberian Husky
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Genetic Stats


Predicted Adult Weight
Genetic Age
23 human years Learn More
Based on the date of birth provided

DNA Breed Origins

What’s this?
Breed colors:
German Shepherd Dog
Gray Wolf
Alaskan Malamute
Siberian Husky

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Summary

0
AT RISK
0
CARRIER
173
CLEAR
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Clinical Traits

These clinical traits are valuable to your veterinarian and can inform the clinical decisions and diagnoses they make.

Alanine Aminotransferase Activity result: Normal
Hiro has two normal alleles at ALT.

Genetic Health Conditions

A genetic health condition indicates a genetic mutation that increases the risk that an animal develops a specific disease.

Not At Risk

Good news! Hiro did not test positive for any of the genetic conditions that Embark screens for.

It is still important to let your veterinarian know these results because they could help guide Hiro’s diagnosis and treatment if he gets sick in the future.

Not A Carrier

Good news! Hiro is not a carrier for any of the genetic conditions that Embark tests for.

Common Conditions

Good news! Hiro tested clear for 13 genetic conditions that are common in his breed mix.
Condition List

MDR1 Drug Sensitivity
(MDR1)
Clinical

Sensitivity to certain classes of drugs, notably the parasiticide ivermectin, as well as certain gastroprotectant and anti-cancer medications, occurs in dogs with mutatio…

Seen in German Shepherd Dogs, but not Hiro.

Factor VII Deficiency
(F7 Exon 5)
Blood

Coagulopathies, disorders of blood clotting, can lead to symptoms such as easy bruising or bleeding. Dogs with coagulopathies are often at risk for excessive bleeding dur…

Seen in Alaskan Malamutes, but not Hiro.

Factor VIII Deficiency, Hemophilia A
(F8 Exon 11, Shepherd Variant 1)
Blood

Coagulopathies, disorders of blood clotting, can lead to symptoms such as easy bruising or bleeding. Dogs with coagulopathies are often at risk for excessive bleeding dur…

Seen in German Shepherd Dogs, but not Hiro.

Factor VIII Deficiency, Hemophilia A
(F8 Exon 1, Shepherd Variant 2)
Blood

Coagulopathies, disorders of blood clotting, can lead to symptoms such as easy bruising or bleeding. Dogs with coagulopathies are often at risk for excessive bleeding dur…

Seen in German Shepherd Dogs, but not Hiro.

Canine Leukocyte Adhesion Deficiency Type III, LAD3
(FERMT3)
Blood

A rare disorder of white blood cells, this causes increased susceptibility to infections and bleeding tendencies. Affected dogs present with a history of persistent skin …

Seen in German Shepherd Dogs, but not Hiro.

Achromatopsia
(CNGA3 Exon 7 German Shepherd Variant)
Eyes

This is a progressive, nonpainful disorder of the retina that affects color vision and light perception. Cone cells not only register color, they allow the dog to adjust …

Seen in German Shepherd Dogs, but not Hiro.

Hyperuricosuria and Hyperuricemia or Urolithiasis, HUU
(SLC2A9)
Kidney and Bladder

This condition causes kidney and bladder stones composed of urate; if caught early, it is responsive to dietary management. Uric acid is an intermediate of purine metabol…

Seen in German Shepherd Dogs, but not Hiro.

X-linked Ectodermal Dysplasia, Anhidrotic Ectodermal Dysplasia
(EDA Intron 8)
Multisystem

This developmental condition can cause a scanty haircoat, malformed teeth, and few or absent sweat glands. Because dogs only have sweat glands on their paw pads, they are…

Seen in German Shepherd Dogs, but not Hiro.

Renal Cystadenocarcinoma and Nodular Dermatofibrosis, RCND
(FLCN Exon 7)
Multisystem

A multiorgan syndrome best described in the German Shepherd Dog, affected dogs display thick skin nodules and signs of kidney disease, and should be evaluated by a veteri…

Seen in German Shepherd Dogs, but not Hiro.

Mucopolysaccharidosis Type VII, Sly Syndrome, MPS VII
(GUSB Exon 3)
Multisystem

A type of lysosomal storage disease, this can cause skeletal abnormalities, growth retardation, and gait abnormalities, and can require close monitoring and special measu…

Seen in German Shepherd Dogs, but not Hiro.

GM1 Gangliosidosis
(GLB1 Exon 15 Alaskan Husky Variant)
Multisystem

An early onset form of lysosomal storage disease, this can cause affected dogs to display neurologic signs as puppies or young adults. These include partial or total visi…

Seen in Siberian Huskys, but not Hiro.

Degenerative Myelopathy, DM
(SOD1A)
Brain and Spinal Cord

A disease of mature dogs, this is a progressive degenerative disorder of the spinal cord that can cause muscle wasting and gait abnormalities. Affected dogs do not usuall…

Seen in German Shepherd Dogs, but not Hiro.

Polyneuropathy, NDRG1 Malamute Variant
(NDRG1 Exon 4)
Brain and Spinal Cord

Polyneuropathy is a progressive neurologic disease that causes peripheral nerve dysfunction. Peripheral nerves relay messages between the brain and spinal cord to the res…

Seen in Alaskan Malamutes, but not Hiro.

Other Conditions:
Clear of 160

Hiro is clear of 160 other genetic conditions that Embark tests for.
Explore the genetics behind your dog’s appearance, size, and genetic diversity.
Coat Color

Coat Color

E Locus (MC1R)
No dark mask or grizzle (Ee)
K Locus (CBD103)
More likely to have a patterned haircoat (kyky)
A Locus (ASIP)
Agouti (Wolf Sable) coat color pattern (awat)
D Locus (MLPH)
Dark areas of hair and skin are not lightened (DD)
B Locus (TYRP1)
Black or gray hair and skin (BB)
Saddle Tan (RALY)
Not expressed (NN)
M Locus (PMEL)
No merle alleles (mm)
Other Coat Traits

Other Coat Traits

Furnishings (RSPO2) LINKAGE
Likely unfurnished (no mustache, beard, and/or eyebrows) (II)
Coat Length (FGF5)
Likely short or mid-length coat (GG)
Shedding (MC5R)
Likely heavy/seasonal shedding (CC)
Coat Texture (KRT71)
Likely straight coat (CC)
Hairlessness (FOXI3) LINKAGE
Very unlikely to be hairless (NN)
Hairlessness (SGK3)
Very unlikely to be hairless (NN)
Oculocutaneous Albinism Type 2 (SLC45A2) LINKAGE
Likely not albino (NN)
Other Body Features

Other Body Features

Muzzle Length (BMP3)
Likely medium or long muzzle (CC)
Tail Length (T)
Likely normal-length tail (CC)
Hind Dewclaws (LMBR1)
Unlikely to have hind dew claws (CC)
Blue Eye Color (ALX4) LINKAGE
Less likely to have blue eyes (NN)
Back Muscling & Bulk, Large Breed (ACSL4)
Likely normal muscling (CC)
Body Size

Body Size

Body Size (IGF1)
Larger (NN)
Body Size (IGFR1)
Larger (GG)
Body Size (STC2)
Larger (TT)
Body Size (GHR - E195K)
Larger (GG)
Body Size (GHR - P177L)
Larger (CC)
Performance

Performance

Altitude Adaptation (EPAS1)
Normal altitude tolerance (GG)

Through Hiro’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

E

Haplotype

E46

Map

E

Hiro’s Haplogroup

Haplogroup E is a very rare maternal line, present primarily in Northern breed dogs and dogs with some level of recent gray wolf ancestry.

E46

Hiro’s Haplotype

Part of the E haplogroup, the E46 haplotype occurs most commonly in Gray Wolves. It's a rare find!

Some other Embark dogs with this haplotype:

An example of an Akita.

Through Hiro’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

C

Haplotype

H5a

Map

C

Hiro’s Haplogroup

C is a relatively rare paternal lineage. The dog populations which bear C are a disparate bunch. The Akita and Shiba Inu are Japanese breeds, the former of which seems to have roots in the Jomon population of hunter-gatherers which were present in the islands of Japan before the ancestors of the modern Japanese arrived. The New Guinea Singing Dog, Samoyed, and Alaska Malamute are all disparate breeds that also represent the C lineage. One village dog from Peru also bore this lineage. This wide distribution and diversity suggest C is not a recently expanded lineage. It likely represents a canid lineage which diversified sometime around the Last Glacial Maximum, when the dogs of Siberia and Oceania split off and went their separate ways.

H5a

Hiro’s Haplotype

Part of the C haplogroup, this haplotype occurs most commonly in Akitas and Alaskan Malamutes.

Some other Embark dogs with this haplotype:

The Shiba Inu descends from this relativey rare haplogroup.