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“Kepi”
High Flying Kepi of Synergon CC CM WC 2014

Afghan Hound

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  • Photo of Kepi, an Afghan Hound  in California, USA Photo of Kepi, an Afghan Hound  in California, USA

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Place of Birth

California, USA

Current Location

New Mexico, USA

This dog has been viewed and been given 16 wags

Genetic Breed Result

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Afghan Hound

The Afghan Hound is a head-turning dog that is as old as they come. These dogs are a sight to behold when reaching top speed with all that hair blowing in the wind. They can make devoted companions with solid but gentle training

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Health Summary

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Kepi inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Degenerative Myelopathy, DM

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Kepi inherited both copies of the variant we tested

What does this result mean?

Research indicates that this genetic variant is not likely to increase the risk that Kepi will develop this condition.

Scientific Basis

Dogs with Kepi’s breed have been included in research studies or have had follow-up by our experts that indicate that this genetic variant is not likely to increase the risk of Kepi developing clinical disease.

Impact on Breeding

This genetic result should not be the primary factor in your breeding decisions.

What is Degenerative Myelopathy, DM?

The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.

ALT Activity

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Kepi inherited one copy of the variant we tested

Why is this important to your vet?

Kepi has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Kepi has this genotype, as ALT is often used as an indicator of liver health and Kepi is likely to have a lower than average resting ALT activity. As such, an increase in Kepi’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Additional Genetic Conditions

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Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Kepi’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

B1

Haplotype

B2a

Map

B1

High Flying Kepi of Synergon’s Haplogroup

B1 is the second most common maternal lineage in breeds of European or American origin. It is the female line of the majority of Golden Retrievers, Basset Hounds, and Shih Tzus, and about half of Beagles, Pekingese and Toy Poodles. This lineage is also somewhat common among village dogs that carry distinct ancestry from these breeds. We know this is a result of B1 dogs being common amongst the European dogs that their conquering owners brought around the world, because nowhere on earth is it a very common lineage in village dogs. It even enables us to trace the path of (human) colonization: Because most Bichons are B1 and Bichons are popular in Spanish culture, B1 is now fairly common among village dogs in Latin America.

B2a

High Flying Kepi of Synergon’s Haplotype

Part of the large B1 haplogroup, we primarily see this haplotype in Salukis and village dogs in and around the Fertile Crescent (Egypt through the Middle East).

Some other Embark dogs with this haplotype:

The B1 haplogroup can be found in village dogs like the Peruvian Village Dog, pictured above.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Kepi inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Kepi is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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