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“Indy”
Heaven's Indiana Beau Von Longbach

Miniature Schnauzer

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Registration

American Kennel Club (AKC): RN37533104

Genetic Breed Result

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Miniature Schnauzer

Miniature Schnauzers are an alert and spirited breed with guard dog tendencies.

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Genetic Stats

Predicted Adult Weight

20 lbs

Genetic Age
14 human years

Based on the date of birth provided

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Health Summary

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Indy inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Factor VII Deficiency

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Indy inherited one copy of the variant we tested

What does this result mean?

Because this variant is inherited in an autosomal recessive manner (meaning dogs need two copies of the variant to develop the disease), Indy is unlikely to develop this condition due to the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of his offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Factor VII Deficiency?

Factor VII deficiency is a type of coagulopathy, a disorder of blood clotting. It is characterized by mild to moderate abnormal bleeding (generally less severe than that caused by deficiencies in other clotting factors such as as Factors VIII or IX). Some dogs with this condition will show no clinical signs.

ALT Activity

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Indy inherited both copies of the variant we tested

Why is this important to your vet?

Indy has two copies of a variant in the GPT gene and is likely to have a lower than average baseline ALT activity. ALT is a commonly used measure of liver health on routine veterinary blood chemistry panels. As such, your veterinarian may want to watch for changes in Indy's ALT activity above their current, healthy, ALT activity. As an increase above Indy’s baseline ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Persistent Mullerian Duct Syndrome, PMDS (AMHR2)

Identified in Miniature Schnauzers

Myotonia Congenita (CLCN1 Exon 7, Miniature Schnauzer Variant)

Identified in Miniature Schnauzers

Demyelinating Polyneuropathy (SBF2/MTRM13)

Identified in Miniature Schnauzers

Additional Genetic Conditions

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Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Indy’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

A388

Map

A1a

Heaven's Indiana Beau Von Longbach’s Haplogroup

A1a is the most common maternal lineage among Western dogs. This lineage traveled from the site of dog domestication in Central Asia to Europe along with an early dog expansion perhaps 10,000 years ago. It hung around in European village dogs for many millennia. Then, about 300 years ago, some of the prized females in the line were chosen as the founding dogs for several dog breeds. That set in motion a huge expansion of this lineage. It's now the maternal lineage of the overwhelming majority of Mastiffs, Labrador Retrievers and Gordon Setters. About half of Boxers and less than half of Shar-Pei dogs descend from the A1a line. It is also common across the world among village dogs, a legacy of European colonialism.

A388

Heaven's Indiana Beau Von Longbach’s Haplotype

Part of the large A1a haplogroup, this haplotype occurs most frequently in Staffordshire Terriers, Labrador Retrievers, and English Bulldogs.

Some other Embark dogs with this haplotype:

Shar Pei dogs think A1a is the coolest!

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Through Indy’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1

Haplotype

Ha.1

Map

A1

Heaven's Indiana Beau Von Longbach’s Haplogroup

A1 is the male lineage in several breeds that aren't very closely related to each other. Gordon Setters, Newfoundlands, and Miniature Schnauzers all had male founders from this paternal line, and now many males in those breeds carry their Y chromosome. Each of these breeds started in the past 200-300 years, and their founders must have included dogs that trace back to the same male ancestors deeper in dog evolutionary time, stretching all the way back to when dogs were first domesticated in Central Asia about 15,000 years ago. Unlike many Y chromosome (male) lineages found in European and recent American breeds, only one village dog (in Alaska) carries an A1 Y chromosome, indicating that the breeds from this lineage probably didn't travel around the world with European colonization as much as some other breeds.

Ha.1

Heaven's Indiana Beau Von Longbach’s Haplotype

The lone member of the A1 haplogroup, this haplotype occurs in Newfoundlands, Miniature Schnauzers, Gordon Setters, and village dogs in Alaska.

Some other Embark dogs with this haplotype:

The Newfoundland is from the A1 paternal line.

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