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Hava

Mixed Ancestry

“She was adopted from the Humane Society shelter in Murray, Utah. I have very little information of her prior life.”

This dog has been viewed and been given 2 wags

Genetic Breed Result

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Australian Shepherd

Australian Shepherds are an energetic mid-sized breed that make the perfect companion.

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Great Pyrenees

The Great Pyrenees is an exceptionally loving dog whose primary function is to protect sheep, goats, livestock, people, children, grass, flowers, the moon, lawn furniture, etc., from any real or imaginary predators that may intrude on your personal space. They have a strong build and an amazing thick white coat that exudes elegance and majesty. They make a great family dog because of their intelligence and steady temperament.

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Border Collie

Border Collies are highly energetic and work-oriented herding dogs, whose stamina is matched by their intelligence and alertness. While they excel at the herding they were bred for, many Border Collies also enjoy flyball, obedience, and other canine sports. As long as they have a job to do and are physically and mentally stimulated, Border Collies can make excellent companions for the right owners.

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Dogs Like Hava

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Discover dogs who share a similar breed mix to Hava. A higher score means the two dogs have more of their breed mix in common. A score of 100% means they share the exact same breed mix!

Click or tap on a pic to learn more about each dog and see an in-depth comparison of their DNA, breeds, and more.

DNA Breed Origins

Breed colors:
Australian Shepherd
Great Pyrenees
Border Collie

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Here’s what Hava’s family tree may have looked like.
While there may be other possible configurations of her family’s relationships, this is the most likely family tree to explain Hava’s breed mix.
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Health Summary

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Hava is at increased risk for one genetic health condition.

And inherited three variants that you should learn more about.

Hereditary Cataracts

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Hava inherited one copy of the variant we tested

How to interpret this result

Hava has one copy of a variant in the HSF4 gene that is thought to cause juvenile cataracts in the Australian Shepherd. variants in HSF4 have been reported in humans with juvenile cataracts; two variants have been identified in dogs. Please consult with your veterinarian regarding further diagnostics and a treatment plan for Hava.

What is Hereditary Cataracts?

Cataracts are the result of a progressive disease of the lens. The lens is normally a transparent structure of precisely organized fibers that lives in the pupil and focuses light. Cataracts cause the lens fibers to become disordered and turns the lens into a milky blue color. The lens is no longer transparent, light fails to reach the retina, and blindness is the end result. With this genetic mutation, dogs can develop cataracts at only a few weeks to months of age.

Progressive Retinal Atrophy, prcd

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Hava inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Hava’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Hava is unlikely to develop this condition due to this variant because she only has one copy of the variant.

What is Progressive Retinal Atrophy, prcd?

PRA-prcd is a retinal disease that causes progressive, non-painful vision loss. The retina contains cells, called photoreceptors, that collect information about light and send signals to the brain. There are two types of photoreceptors: rods, for night vision and movement, and cones, for day vision and color. This type of PRA leads to early loss of rod cells, leading to night blindness before day blindness.

Degenerative Myelopathy, DM

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Hava inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Hava’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Hava is unlikely to develop this condition due to this variant because she only has one copy of the variant.

What is Degenerative Myelopathy, DM?

The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.

ALT Activity

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Hava inherited one copy of the variant we tested

Why is this important to your vet?

Hava has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Hava has this genotype, as ALT is often used as an indicator of liver health and Hava is likely to have a lower than average resting ALT activity. As such, an increase in Hava’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Multiple Drug Sensitivity

Identified in Australian Shepherds and Border Collies

Glanzmann's Thrombasthenia Type I

Identified in Great Pyrenees

Trapped Neutrophil Syndrome, TNS

Identified in Border Collies

Collie Eye Anomaly

Identified in Australian Shepherds and Border Collies

Canine Multifocal Retinopathy, cmr1

Identified in Australian Shepherds and Great Pyrenees

Primary Lens Luxation

Identified in Border Collies

Urate Kidney & Bladder Stones

Identified in Australian Shepherds

Neuronal Ceroid Lipofuscinosis 5, NCL 5

Identified in Border Collies

Neuronal Ceroid Lipofuscinosis 6, NCL 6

Identified in Australian Shepherds

Neuronal Ceroid Lipofuscinosis 8, NCL 8

Identified in Australian Shepherds

Myotonia Congenita

Identified in Border Collies

Cobalamin Malabsorption

Identified in Border Collies

Craniomandibular Osteopathy, CMO

Identified in Australian Shepherds

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Base Coat Color

Base Coat Color

Coat Color Modifiers

Coat Color Modifiers

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

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Through Hava’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

B1

Haplotype

B1b

Map

B1

Hava’s Haplogroup

B1 is the second most common maternal lineage in breeds of European or American origin. It is the female line of the majority of Golden Retrievers, Basset Hounds, and Shih Tzus, and about half of Beagles, Pekingese and Toy Poodles. This lineage is also somewhat common among village dogs that carry distinct ancestry from these breeds. We know this is a result of B1 dogs being common amongst the European dogs that their conquering owners brought around the world, because nowhere on earth is it a very common lineage in village dogs. It even enables us to trace the path of (human) colonization: Because most Bichons are B1 and Bichons are popular in Spanish culture, B1 is now fairly common among village dogs in Latin America.

B1b

Hava’s Haplotype

Part of the large B1 haplogroup, we see this haplotype in village dogs across the world, including those from Central America, the Middle East, South Asia, and the French Polynesian Islands. Among the 31 breed dogs we see it in, we see it in Poodles, Otterhounds, and Labrador Retrievers. It is also our most commonly-sampled Golden Retriever haplotype!

The B1 haplogroup can be found in village dogs like the Peruvian Village Dog, pictured above.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Hava inherited from her mom and dad? Check out her breed breakdown and family tree.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Hava is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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