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Hattie

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“F2 Mini Bernedoodle”

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Health Summary

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Hattie has one variant that you should let your vet know about.

ALT Activity

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Hattie inherited one copy of the variant we tested

Why is this important to your vet?

Hattie has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Hattie has this genotype, as ALT is often used as an indicator of liver health and Hattie is likely to have a lower than average resting ALT activity. As such, an increase in Hattie’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Von Willebrand Disease Type I, Type I vWD (VWF)

Identified in Bernese Mountain Dogs and Small Poodles

Progressive Retinal Atrophy, prcd (PRCD Exon 1)

Identified in Small Poodles

GM2 Gangliosidosis (HEXB, Poodle Variant)

Identified in Small Poodles

Persistent Mullerian Duct Syndrome, PMDS (AMHR2)

Identified in Miniature Schnauzers

Degenerative Myelopathy, DM (SOD1A)

Identified in Bernese Mountain Dogs

Neonatal Encephalopathy with Seizures, NEWS (ATF2)

Identified in Small Poodles

Myotonia Congenita (CLCN1 Exon 7, Miniature Schnauzer Variant)

Identified in Miniature Schnauzers

Demyelinating Polyneuropathy (SBF2/MTRM13)

Identified in Miniature Schnauzers

Osteochondrodysplasia (SLC13A1, Poodle Variant)

Identified in Small Poodles

Intervertebral Disc Disease (Type I) (FGF4 retrogene - CFA12)

Identified in Small Poodles

Additional Genetic Conditions

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