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“Harley - BBDD, vWD, DCM2”
Harley Quinn Birkline

Doberman Pinscher

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“Harley is a true Doberdiva. She wants our neighbors to think she fits the vicious reputation, but in reality, she sucks her blankie and needs her daddy's approval.”

Place of Birth

Texas, USA

Current Location

Humble, Texas, USA

From

Texas, USA

This dog has been viewed and been given 1 wag

Registration

American Kennel Club (AKC): WS61967003

Genetic Breed Result

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Doberman Pinscher

Doberman Pinschers are a strong and athletic breed that are built to guard and protect.

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Changes to this dog’s profile
  • On 5/2/2021 changed name from "Harley Quinn" to "Harley Quinn Birkline"

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Health Summary

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Harley - BBDD, vWD, DCM2 is at increased risk for one genetic health condition.

And inherited two variants that you should learn more about.

Dilated Cardiomyopathy, DCM2

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Harley - BBDD, vWD, DCM2 inherited one copy of the variant we tested

How to interpret this result

Harley - BBDD, vWD, DCM2 has one copy of a variant in the TTN gene associated with increased risk for DCM in the American Doberman Pinscher. This variant, also referred to as DCM2, is inherited in a dominant manner, meaning having one or two copies of this variant is thought to confer the same amount of risk. However, the variant is thought to have incomplete penetrance: That is, not all dogs with this variant will ultimately show signs of DCM. Moreover, the impact of this variant in other breeds of dog besides the Doberman has yet to be fully understood. However, if your veterinarian thinks Harley - BBDD, vWD, DCM2 shows signs of having DCM based on their diagnostic testing, you now have the opportunity to discuss early treatment. Please consult with your veterinarian regarding a diagnostic and treatment plan for Harley - BBDD, vWD, DCM2.

What is Dilated Cardiomyopathy, DCM2?

DCM is the most common acquired heart disease of adult dogs. The heart has two heavily muscled ventricles that pump blood away from the heart. This disease causes progressive weakening of the ventricles by reducing the muscle mass, which causes the ventricles to dilate. Dilated ventricles do not contract and circulate oxygenated blood well, which eventually leads to heart failure.

Von Willebrand Disease Type I, Type I vWD

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Harley - BBDD, vWD, DCM2 inherited one copy of the variant we tested

What does this result mean?

This result should not impact Harley - BBDD, vWD, DCM2’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring.

What is Von Willebrand Disease Type I, Type I vWD?

Von Willebrand Disease (vWD) is a type of coagulopathy, a disorder of blood clotting. vWD is characterized into three types based on clinical severity, serum levels of vWF, and vWF multimer composition. Dogs with Type I vWD have low vWF levels, normal multimer composition, and variable clinical signs.

ALT Activity

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Harley - BBDD, vWD, DCM2 inherited one copy of the variant we tested

Why is this important to your vet?

Harley - BBDD, vWD, DCM2 has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Harley - BBDD, vWD, DCM2 has this genotype, as ALT is often used as an indicator of liver health and Harley - BBDD, vWD, DCM2 is likely to have a lower than average resting ALT activity. As such, an increase in Harley - BBDD, vWD, DCM2’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Deafness and Vestibular Syndrome of Dobermans, DVDob, DINGS (MYO7A)

Identified in Doberman Pinschers

Dilated Cardiomyopathy, DCM1 (PDK4, Doberman Pinscher Variant 1)

Identified in Doberman Pinschers

Additional Genetic Conditions

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Through Harley - BBDD, vWD, DCM2’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1b

Haplotype

A408

Map

A1b

Harley Quinn Birkline’s Haplogroup

This female lineage was very likely one of the original lineages in the wolves that were first domesticated into dogs in Central Asia about 15,000 years ago. Since then, the lineage has been very successful and travelled the globe! Dogs from this group are found in ancient Bronze Age fossils in the Middle East and southern Europe. By the end of the Bronze Age, it became exceedingly common in Europe. These dogs later became many of the dogs that started some of today's most popular breeds, like German Shepherds, Pugs, Whippets, English Sheepdogs and Miniature Schnauzers. During the period of European colonization, the lineage became even more widespread as European dogs followed their owners to far-flung places like South America and Oceania. It's now found in many popular breeds as well as village dogs across the world!

A408

Harley Quinn Birkline’s Haplotype

Part of the A1b haplogroup, the A408 haplotype occurs most commonly in Doberman Pinschers. It's a rare find!

Some other Embark dogs with this haplotype:

A1b is the most common haplogroup found in German Shepherds.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Harley - BBDD, vWD, DCM2 inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Harley - BBDD, vWD, DCM2 is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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