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Harley

Mixed Ancestry

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Genetic Breed Result

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Staffordshire Terrier

Staffordshire Terriers, sometimes referred to as "pit bull" type, are intelligent and trainable dogs. They can have a lot of energy and are often great canine athletes!

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Golden Retriever

Developed as an ideal hunting retriever, the Golden Retriever's eagerness to please and friendliness has made them an extremely popular family pet.

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Australian Cattle Dog

A classic cattle dog, Australian Cattle Dogs were developed from a mixture of breeds in Australia in the 19th century, and still maintain their energetic herding instincts today.

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Great Pyrenees

The Great Pyrenees is an exceptionally loving dog whose primary function is to protect sheep, goats, livestock, people, children, grass, flowers, the moon, lawn furniture, etc., from any real or imaginary predators that may intrude on your personal space. They have a strong build and an amazing thick white coat that exudes elegance and majesty. They make a great family dog because of their intelligence and steady temperament.

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Dogs Like Harley

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Discover dogs who share a similar breed mix to Harley. A higher score means the two dogs have more of their breed mix in common. A score of 100% means they share the exact same breed mix!

Click or tap on a pic to learn more about each dog and see an in-depth comparison of their DNA, breeds, and more.

DNA Breed Origins

Breed colors:
Staffordshire Terrier
Golden Retriever
Australian Cattle Dog
Great Pyrenees

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Here’s what Harley’s family tree may have looked like.
While there may be other possible configurations of her family’s relationships, this is the most likely family tree to explain Harley’s breed mix.
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Health Summary

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Harley inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Progressive Retinal Atrophy, crd4/cord1

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Harley inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Harley’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Harley is unlikely to develop this condition due to this variant because she only has one copy of the variant.

What is Progressive Retinal Atrophy, crd4/cord1?

PRA-CRD4/cord1 is a retinal disease that causes progressive, non-painful vision loss over a 1-2 year period. The retina contains cells, called photoreceptors, that collect information about light and send signals to the brain. There are two types of photoreceptors: rods, for night vision and movement, and cones, for day vision and color. This type of PRA leads to early loss of cone cells, causing day blindness before night blindness.

ALT Activity

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Harley inherited one copy of the variant we tested

Why is this important to your vet?

Harley has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Harley has this genotype, as ALT is often used as an indicator of liver health and Harley is likely to have a lower than average resting ALT activity. As such, an increase in Harley’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Multiple Drug Sensitivity

Identified in Australian Cattle Dogs

Glanzmann's Thrombasthenia Type I

Identified in Great Pyrenees

Progressive Retinal Atrophy, prcd

Identified in Australian Cattle Dogs and Golden Retrievers

Golden Retriever Progressive Retinal Atrophy 1, GR-PRA1

Identified in Golden Retrievers

Golden Retriever Progressive Retinal Atrophy 2, GR-PRA2

Identified in Golden Retrievers

Progressive Retinal Atrophy, crd1

Identified in Staffordshire Terriers

Progressive Retinal Atrophy, crd2

Identified in Staffordshire Terriers

Canine Multifocal Retinopathy, cmr1

Identified in Great Pyrenees

Hereditary Cataracts

Identified in Staffordshire Terriers

Primary Lens Luxation

Identified in Australian Cattle Dogs

Cystinuria Type II-A

Identified in Australian Cattle Dogs

Urate Kidney & Bladder Stones

Identified in Staffordshire Terriers

Neuronal Ceroid Lipofuscinosis, Cerebellar Ataxia, NCL4A

Identified in Staffordshire Terriers

Neuronal Ceroid Lipofuscinosis 5, NCL 5

Identified in Australian Cattle Dogs

Neuronal Ceroid Lipofuscinosis 8, NCL 8

Identified in Australian Cattle Dogs

Neuronal Ceroid Lipofuscinosis 5, NCL 5

Identified in Golden Retrievers

L-2-Hydroxyglutaricaciduria, L2HGA

Identified in Staffordshire Terriers

Muscular Dystrophy

Identified in Golden Retrievers

Myotonia Congenita

Identified in Australian Cattle Dogs

Dystrophic Epidermolysis Bullosa

Identified in Golden Retrievers

Ichthyosis, ICH1

Identified in Golden Retrievers

Osteogenesis Imperfecta

Identified in Golden Retrievers

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Base Coat Color

Base Coat Color

Coat Color Modifiers

Coat Color Modifiers

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Harley’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

A17

Map

A1a

Harley’s Haplogroup

A1a is the most common maternal lineage among Western dogs. This lineage traveled from the site of dog domestication in Central Asia to Europe along with an early dog expansion perhaps 10,000 years ago. It hung around in European village dogs for many millennia. Then, about 300 years ago, some of the prized females in the line were chosen as the founding dogs for several dog breeds. That set in motion a huge expansion of this lineage. It's now the maternal lineage of the overwhelming majority of Mastiffs, Labrador Retrievers and Gordon Setters. About half of Boxers and less than half of Shar-Pei dogs descend from the A1a line. It is also common across the world among village dogs, a legacy of European colonialism.

A17

Harley’s Haplotype

Part of the large A1a haplogroup, this common haplotype is found in village dogs across the globe. Among breed dogs, we find it most frequently in Labrador Retrievers, Boxers, and Mastiffs.

Shar Pei dogs think A1a is the coolest!

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Harley inherited from her mom and dad? Check out her breed breakdown and family tree.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Harley is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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