Quest inherited both copies of the variant we tested
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“Quest is a well bred purebred GSD. He does not have any Shiloh Shepherd and has a pedigree of personally known show dogs. No show person would breed a Shiloh into their program for any reason- aside from ethics, they lack the angles and movement that win in the GSD ring, so it would be counter-productive. The confusion is likely due to a Shiloh breeder using one of his relatives in their program and then Embarking their dogs as Shilohs. Quest is an awesome dog with a wonderful temperament :-)”
Place of Birth
Pittsburgh, PA, USA
Current Location
Florida, USA
From
Pittsburgh, PA, USA
This dog has been viewed and been given 17 wags
Registration
American Kennel Club
(AKC):
Start a conversation! Message this dog’s owner.
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Changes to this dog’s profile
- On 7/13/2018 changed name from "Laugesen Manor Seas The Day" to "Anka von Wesphalen"
- On 7/13/2018 changed name from "Anka von Wesphalen" to "Hammersmith Can I Kick It"
- On 7/13/2018 changed handle from "poeticwhippet" to "gsdonaquest"
- On 6/29/2018 changed name from "A'Eden Zipline Zoom" to "Laugesen Manor Seas The Day"
- On 6/29/2018 changed handle from "aedenziplinezoom" to "poeticwhippet"
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Health Summary
Quest is at increased risk for one genetic health condition.
And inherited one variant that you should learn more about.
Degenerative Myelopathy, DM
How to interpret this result
Quest has two copies of a variant in SOD1 and is at risk for developing DM. As previously stated, this variant is incompletely penetrant, so while it predisposes Quest to developing DM, other genetic and environmental factors will determine whether Quest ultimately develops the disease. Please consult your veterinarian to discuss further diagnostic, monitoring, and supportive care options for Quest.'
What is Degenerative Myelopathy, DM?
The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.
ALT Activity
Quest inherited one copy of the variant we tested
Why is this important to your vet?
Quest has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Quest has this genotype, as ALT is often used as an indicator of liver health and Quest is likely to have a lower than average resting ALT activity. As such, an increase in Quest’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.
What is ALT Activity?
Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.
Breed-Relevant Genetic Conditions
Multiple Drug Sensitivity (ABCB1)
Identified in German Shepherd Dogs and Shiloh Shepherds
Variant not detected
Hemophilia A (F8 Exon 11, German Shepherd Variant 1)
Identified in German Shepherd Dogs and Shiloh Shepherds
Variant not detected
Hemophilia A (F8 Exon 1, German Shepherd Variant 2)
Identified in German Shepherd Dogs and Shiloh Shepherds
Variant not detected
Canine Leukocyte Adhesion Deficiency Type III, CLAD III (FERMT3, German Shepherd Variant)
Identified in German Shepherd Dogs and Shiloh Shepherds
Variant not detected
Day Blindness (CNGA3 Exon 7, German Shepherd Variant)
Identified in German Shepherd Dogs and Shiloh Shepherds
Variant not detected
Urate Kidney & Bladder Stones (SLC2A9)
Identified in German Shepherd Dogs and Shiloh Shepherds
Variant not detected
Anhidrotic Ectodermal Dysplasia (EDA Intron 8)
Identified in German Shepherd Dogs and Shiloh Shepherds
Variant not detected
Renal Cystadenocarcinoma and Nodular Dermatofibrosis (FLCN Exon 7)
Identified in German Shepherd Dogs and Shiloh Shepherds
Variant not detected
Mucopolysaccharidosis Type VII, Sly Syndrome, MPS VII (GUSB Exon 3, German Shepherd Variant)
Identified in German Shepherd Dogs and Shiloh Shepherds
Variant not detected
Additional Genetic Conditions
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What is a linkage test?
DNA sequences that are close together on a chromosome tend to be inherited together. Because of this, we can use genetic variation surrounding a specific variant (i.e. "linked" to it) to infer the presence or absence of a variant that is associated with a health condition or trait.
Linkage tests are not as predictive of your dog’s true genotype as direct assays, which we use on most other genetic conditions we test for.
Traits
Explore the genetics behind your dog’s appearance and size.
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Coat Color
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Other Coat Traits
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Other Body Features
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Body Size
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.