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GrCh. Venomline South’s Riot of X-File Bullies

American Bully

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Place of Birth

North Carolina, USA

Current Location

Delaware, USA

From

North Carolina, USA

This dog has been viewed and been given 10 wags

Registration

American Bully Kennel Club (ABKC):

Genetic Breed Result

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American Bully

The American Bully may look intimidating with its muscular build, but these dogs are bred to be the ideal family or companion dog. This breed is notable for coming in several different size and type varieties, so there's a lot of diversity in their appearance. They're a newer breed, originating in the 80s and 90s in the United States.

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Health Summary

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GrCh. Venomline South’s Riot of X-File Bullies inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Progressive Retinal Atrophy, crd4/cord1

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GrCh. Venomline South’s Riot of X-File Bullies inherited both copies of the variant we tested

What does this result mean?

We do not know whether this increases the risk that GrCh. Venomline South’s Riot of X-File Bullies will develop Progressive Retinal Atrophy, crd4/cord1.

Scientific Basis

Research studies for this variant have been based on dogs of other breeds. Not enough dogs with GrCh. Venomline South’s Riot of X-File Bullies's breed have been studied to know whether or not this variant will increase GrCh. Venomline South’s Riot of X-File Bullies's risk of developing this disease.

Impact on Breeding

Research into the clinical impact of this variant is ongoing. We recommend tracking this genetic result and incidence of Progressive Retinal Atrophy, crd4/cord1 in your breeding program and related dogs.

What is Progressive Retinal Atrophy, crd4/cord1?

PRA-CRD4/cord1 is a retinal disease that causes progressive, non-painful vision loss over a 1-2 year period. The retina contains cells, called photoreceptors, that collect information about light and send signals to the brain. There are two types of photoreceptors: rods, for night vision and movement, and cones, for day vision and color. This type of PRA leads to early loss of cone cells, causing day blindness before night blindness.

ALT Activity

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GrCh. Venomline South’s Riot of X-File Bullies inherited one copy of the variant we tested

Why is this important to your vet?

GrCh. Venomline South’s Riot of X-File Bullies has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that GrCh. Venomline South’s Riot of X-File Bullies has this genotype, as ALT is often used as an indicator of liver health and GrCh. Venomline South’s Riot of X-File Bullies is likely to have a lower than average resting ALT activity. As such, an increase in GrCh. Venomline South’s Riot of X-File Bullies’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Progressive Retinal Atrophy, crd1 (PDE6B, American Staffordshire Terrier Variant)

Identified in American Bullies

Canine Multifocal Retinopathy, cmr1 (BEST1 Exon 2)

Identified in American Bullies

Urate Kidney & Bladder Stones (SLC2A9)

Identified in American Bullies

Neuronal Ceroid Lipofuscinosis, Cerebellar Ataxia, NCL4A (ARSG Exon 2, American Staffordshire Terrier Variant)

Identified in American Bullies

Neuronal Ceroid Lipofuscinosis 10, NCL 10 (CTSD Exon 5, American Bulldog Variant)

Identified in American Bullies

L-2-Hydroxyglutaricaciduria, L2HGA (L2HGDH, Staffordshire Bull Terrier Variant)

Identified in American Bullies

Nemaline Myopathy (NEB, American Bulldog Variant)

Identified in American Bullies

Ichthyosis (NIPAL4, American Bulldog Variant)

Identified in American Bullies

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through GrCh. Venomline South’s Riot of X-File Bullies’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

B1

Haplotype

B1c

Map

B1

GrCh. Venomline South’s Riot of X-File Bullies’s Haplogroup

B1 is the second most common maternal lineage in breeds of European or American origin. It is the female line of the majority of Golden Retrievers, Basset Hounds, and Shih Tzus, and about half of Beagles, Pekingese and Toy Poodles. This lineage is also somewhat common among village dogs that carry distinct ancestry from these breeds. We know this is a result of B1 dogs being common amongst the European dogs that their conquering owners brought around the world, because nowhere on earth is it a very common lineage in village dogs. It even enables us to trace the path of (human) colonization: Because most Bichons are B1 and Bichons are popular in Spanish culture, B1 is now fairly common among village dogs in Latin America.

B1c

GrCh. Venomline South’s Riot of X-File Bullies’s Haplotype

Part of the large B1 haplogroup, we have detected this haplotype in Mexico and Lebanon village dogs. Among the 12 breeds that we have spotted this haplotype in, it occurs most frequently in Border Collies, Australian Shepherd Dogs, and West Highland white Terriers.

Some other Embark dogs with this haplotype:

The B1 haplogroup can be found in village dogs like the Peruvian Village Dog, pictured above.

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Through GrCh. Venomline South’s Riot of X-File Bullies’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

D

Haplotype

H7.1/6/7

Map

D

GrCh. Venomline South’s Riot of X-File Bullies’s Haplogroup

The D paternal lineage is very common in well-known populations of dogs. Breeds belonging to the D lineage likely have direct male ancestors that can be traced all the way back to the origin of domestic dogs themselves! One popular breed that commonly sports a D lineage is the Boxer. Boxers were developed in the late 19th century from Mastiff dogs, so it is no surprise that D is well represented among Mastiffs, Bulldogs, as well as Terriers. Intriguingly, D is also found among Lhasa Apsos, an ancient Tibetan breed, and Afghan Hounds. While the presence of this lineage in Polynesia or the New World can be chalked up to interbreeding with European dogs brought during voyages of discovery or later settlement, D is also well represented among village dog populations in the Middle East and Africa. If the fact that we find dogs bearing a D lineage in the Middle East (not to mention the large amount of diversity among Middle Eastern D lineage males) is any indication of ancient residence in that region, then the presence among Oceanian village dogs is peculiar. Rather, it may be that D is part of a broader Eurasian group of ancient paternal lineages which disappeared from the eastern portion of its original range, persisting in the island of New Guinea as well as West Asia and Africa. With the rise of Mastiff breeds, the D lineage received a new life as it became common among many types of working dogs.

H7.1/6/7

GrCh. Venomline South’s Riot of X-File Bullies’s Haplotype

Part of the D haplogroup, this haplotype occurs most frequently in mixed breed dogs.

Some other Embark dogs with this haplotype:

The D paternal lineage is common in Boxers.

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