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Gizmo

Mixed Ancestry

“He loves to play and run, will pickup anything you ask him to. Looks for things to bring you, too smart for his own good. Very easy to train. Developed Diabetes 4 months after his 3rd birthday and has had one mishap that caused IVDD to flair up but after 3 weeks is back to playing and running again.”

Place of Birth

Oshawa, Ontario, Canada

Current Location

Oshawa, Ontario, Canada

From

Oshawa, Ontario, Canada

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Genetic Breed Result

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Pug

The Pug is a breed of dog with a wrinkly, short-muzzled face and curled tail. Pugs are known for being sociable and gentle companion dogs.

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Poodle (Small)

A highly intelligent and playful dog, Miniature and Toy Poodles make for great lap dogs and companions.

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Pomeranian

The Pomeranian is a cocky, animated companion with an extroverted personality.

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Boston Terrier

Boston Terriers are lively, intelligent and friendly. Although a small dog, they are strong and sturdy. Owners of this breed find them to be As the breed's name implies, the Boston Terrier originated in the city of Boston in the late 19th century. They're sometimes referred to be their nickname of the "American gentleman" because of their tuxedo-like coat.

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Biewer Terrier

The Biewer Terrier is one of the smallest Terriers within the Toy Group, only 7-8 inches tall and typically less than 8 pounds. In spite of the small size, the Biewer is known as a robust and athletic dog.

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Cocker Spaniel

Cocker Spaniels are handsome and intelligent hunting dogs that are also well-suited to life as a loving family pet.

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Japanese Chin

The Japanese Chin is a little breed that was born to rule the roost. Though Chinese in origin, these dogs were brought to Japan to serve as the companions of Japanese dignitaries. This is a loving dog that knows it is the real deal.

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Dogs Like Gizmo

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Discover dogs who share a similar breed mix to Gizmo. A higher score means the two dogs have more of their breed mix in common. A score of 100% means they share the exact same breed mix!

Click or tap on a pic to learn more about each dog and see an in-depth comparison of their DNA, breeds, and more.

DNA Breed Origins

Breed colors:
Pug
Poodle (Small)
Pomeranian
Boston Terrier
Biewer Terrier
Cocker Spaniel
Japanese Chin

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Here’s what Gizmo’s family tree may have looked like.
Gizmo
Family Tree From Embark PARENTS GRANDPARENTS GREAT GRANDPARENTS Mixed Mixed Poodle (Small) / Pomeranian mix Pug / Biewer Terrier mix Pug / Boston Terrier mix Poodle (Small) / Pomeranian mix Poodle (Small) Pomeranian mix Pug Biewer Terrier mix Pug Boston Terrier mix Poodle (Small) Pomeranian mix
While there may be other possible configurations of his family’s relationships, this is the most likely family tree to explain Gizmo’s breed mix.

Breed Reveal Video

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Health Summary

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Gizmo is at increased risk for two genetic health conditions.

And inherited one variant that you should learn more about.

Degenerative Myelopathy, DM

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Gizmo inherited both copies of the variant we tested

How to interpret this result

Gizmo has two copies of a variant in SOD1 and is at risk for developing DM. As previously stated, this variant is incompletely penetrant, so while it predisposes Gizmo to developing DM, other genetic and environmental factors will determine whether Gizmo ultimately develops the disease. Please consult your veterinarian to discuss further diagnostic, monitoring, and supportive care options for Gizmo.'

What is Degenerative Myelopathy, DM?

The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.

Intervertebral Disc Disease (Type I)

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Gizmo inherited one copy of the variant we tested

How to interpret this result

Gizmo has one copy of an FGF4 retrogene on chromosome 12. In some breeds such as Beagles, Cocker Spaniels, and Dachshunds (among others) this variant is found in nearly all dogs. While those breeds are known to have an elevated risk of IVDD, many dogs in those breeds never develop IVDD. For mixed breed dogs and purebreds of other breeds where this variant is not as common, risk for Type I IVDD is greater for individuals with this variant than for similar dogs.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

ALT Activity

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Gizmo inherited both copies of the variant we tested

Why is this important to your vet?

Gizmo has two copies of a variant in the GPT gene and is likely to have a lower than average baseline ALT activity. ALT is a commonly used measure of liver health on routine veterinary blood chemistry panels. As such, your veterinarian may want to watch for changes in Gizmo's ALT activity above their current, healthy, ALT activity. As an increase above Gizmo’s baseline ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Von Willebrand Disease Type I, Type I vWD

Identified in Small Poodles

May-Hegglin Anomaly

Identified in Pugs

Pyruvate Kinase Deficiency

Identified in Pugs

Methemoglobinemia

Identified in Pomeranians

Progressive Retinal Atrophy, rcd3

Identified in Pomeranians

Progressive Retinal Atrophy, prcd

Identified in Biewer Terriers, Cocker Spaniels, and more

Primary Lens Luxation

Identified in Biewer Terriers

Urate Kidney & Bladder Stones

Identified in Pomeranians

Familial Nephropathy

Identified in Cocker Spaniels

Glycogen storage disease Type VII, Phosphofructokinase Deficiency, PFK Deficiency

Identified in Cocker Spaniels

GM2 Gangliosidosis

Identified in Small Poodles

GM2 Gangliosidosis

Identified in Japanese Chins

Neonatal Encephalopathy with Seizures, NEWS

Identified in Small Poodles

Acral Mutilation Syndrome

Identified in Cocker Spaniels

Limb Girdle Muscular Dystrophy

Identified in Boston Terriers

Exercise-Induced Collapse, EIC

Identified in Cocker Spaniels

Oculocutaneous Albinism, OCA

Identified in Pomeranians

Hereditary Vitamin D-Resistant Rickets

Identified in Pomeranians

Osteochondrodysplasia

Identified in Small Poodles

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Base Coat Color

Base Coat Color

Coat Color Modifiers

Coat Color Modifiers

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Gizmo’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

C2

Haplotype

C42/54/55

Map

C2

Gizmo’s Haplogroup

C2 is a very old female lineage found more commonly among English Setters, English Bulldogs, and American Eskimo Dogs. We also see C2 in village dogs in South Asia. Rather than having a few characteristic breeds representing this lineage particularly well, it is present in a few uncommon individuals of many different breeds. Unlike some European breed lineages that have seen skyrocketing popularity along the path to the modern dogs we see today, C2 tends to reflect the deep history of man's best friend.

C42/54/55

Gizmo’s Haplotype

Part of the C2 haplogroup, this haplotype occurs most frequently in mixed breed dogs.

You can often find his haplogroup in the lovable English Bulldog.

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Through Gizmo’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A2b

Haplotype

Ambiguous_A2b

Map

A2b

Gizmo’s Haplogroup

A2b appears to have split a few times in succession, which means that some of the Central Asian male ancestors of this lineage went their separate ways before their respective Y chromosomes made their rounds. There is not much diversity in this lineage, meaning that it has only begun to take off recently. Two iconic breeds, the Dachshund and Bloodhound, represent this lineage well. Over half of Rottweilers are A2b, as are the majority of Labrador Retrievers and Cavalier King Charles Spaniels. While A2a is restricted mostly to East Asia, this paternal line is also found among European breeds.

Ambiguous_A2b

Gizmo’s Haplotype

Paternal haplotypes are defined such that every unique marker we test for is necessary to make a confident call. In the case of your dog, there were too many missing Y-chromosome markers to reliably define a haplotype this way. However, we know your dog falls in the A2b haplogroup, which we can define more broadly.

A2b is found in the Daschund breed.

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