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“Gait”
Gerse Gerrit v.d. Walewoefjes

Markiesje

No bio has been provided yet

Place of Birth

Castricum, Noord-Holland, Nederland

Current Location

Emmen, Drenthe, Nederland

From

Castricum, Noord-Holland, Nederland

This dog has been viewed and been given 19 wags

Registration

N/A : VR 3060110

Genetic Breed Result

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Markiesje

The Markiesje, also known as the Dutch Tulip Hound, is a companion dog bred since the 1970s. They are considered a "reconstructed" breed, based on depictions of old Dutch dogs. Markiesje are notable for being intelligent, friendly, and sweet.

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Health Summary

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Gait is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Intervertebral Disc Disease (Type I)

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Gait inherited one copy of the variant we tested

What does this result mean?

Follow-up by our experts indicates that this genetic variant is associated with an increase to Gait’s risk for developing Intervertebral Disc Disease (Type I).

Scientific Basis

Research studies for this variant have been based on dogs of other breeds. While dogs with similar breeds to Gait have not yet been the focus of research studies, our data indicates that Gait is likely to be at increased risk.

Impact on Breeding

While further investigation is warranted to determine the clinical presentation and penetrance in Gait’s breed, we recommend taking this genetic result into account when making breeding decisions.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

ALT Activity

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Gait inherited one copy of the variant we tested

Why is this important to your vet?

Gait has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Gait has this genotype, as ALT is often used as an indicator of liver health and Gait is likely to have a lower than average resting ALT activity. As such, an increase in Gait’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Progressive Retinal Atrophy, prcd (PRCD Exon 1)

Identified in Markiesje

Additional Genetic Conditions

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Traits

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Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

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Other Body Features

Body Size

Body Size

Performance

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Through Gait’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1d

Haplotype

A11a/419

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A1d

Gerse Gerrit v.d. Walewoefjes’s Haplogroup

This female lineage can be traced back about 15,000 years to some of the original Central Asian wolves that were domesticated into modern dogs. The early females that represent this lineage were likely taken into Eurasia, where they spread rapidly. As a result, many modern breed and village dogs from the Americas, Africa, through Asia and down into Oceania belong to this group! This widespread lineage is not limited to a select few breeds, but the majority of Rottweilers, Afghan Hounds and Wirehaired Pointing Griffons belong to it. It is also the most common female lineage among Papillons, Samoyeds and Jack Russell Terriers. Considering its occurrence in breeds as diverse as Afghan Hounds and Samoyeds, some of this is likely ancient variation. But because of its presence in many modern European breeds, much of its diversity likely can be attributed to much more recent breeding.

A11a/419

Gerse Gerrit v.d. Walewoefjes’s Haplotype

Part of the A1d haplogroup, this haplotype occurs most frequently in Yorkshire Terriers, Old English Sheepdogs, and Miniature Schnauzers.

The vast majority of Rottweilers have the A1d haplogroup.

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Through Gait’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

H1a.53

Map

A1a

Gerse Gerrit v.d. Walewoefjes’s Haplogroup

Some of the wolves that became the original dogs in Central Asia around 15,000 years ago came from this long and distinguished line of male dogs. After domestication, they followed their humans from Asia to Europe and then didn't stop there. They took root in Europe, eventually becoming the dogs that founded the Vizsla breed 1,000 years ago. The Vizsla is a Central European hunting dog, and all male Vizslas descend from this line. During the Age of Exploration, like their owners, these pooches went by the philosophy, "Have sail, will travel!" From the windy plains of Patagonia to the snug and homey towns of the American Midwest, the beaches of a Pacific paradise, and the broad expanse of the Australian outback, these dogs followed their masters to the outposts of empires. Whether through good fortune or superior genetics, dogs from the A1a lineage traveled the globe and took root across the world. Now you find village dogs from this line frolicking on Polynesian beaches, hanging out in villages across the Americas, and scavenging throughout Old World settlements. You can also find this "prince of patrilineages" in breeds as different as German Shepherds, Golden Retrievers, Pugs, Border Collies, Scottish Terriers, and Irish Wolfhounds. No male wolf line has been as successful as the A1a line!

H1a.53

Gerse Gerrit v.d. Walewoefjes’s Haplotype

Part of the A1a haplogroup, this haplotype occurs most frequently in Golden Retrievers, Border Collies, and the Coton de Tulear.

Dogs with A1a lineage travelled during European Colonial times.

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