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“Harriet”
Freya DSK

Doberman Pinscher

No bio has been provided yet

Place of Birth

USA

Current Location

Colorado, USA

From

California, USA

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Registration

American Kennel Club (AKC): WS73447606

Genetic Breed Result

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Doberman Pinscher

Doberman Pinschers are a strong and athletic breed that are built to guard and protect.

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Health Summary

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Harriet is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Dilated Cardiomyopathy, DCM1

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Harriet inherited both copies of the variant we tested

How to interpret this result

Harriet has two copies of a variant in the PDK4 gene associated with increased risk for DCM in the American Doberman Pinscher. This variant, also referred to as DCM1, is inherited in a dominant manner, meaning having one or two copies of this variant is thought to confer the same amount of risk. However, the variant is thought to have incomplete penetrance: That is, not all dogs with this variant will ultimately show signs of DCM. Moreover, the impact of this variant in other breeds of dog besides the Doberman has yet to be fully understood. However, if your veterinarian thinks Harriet shows signs of having DCM based on their diagnostic testing, you now have the opportunity to discuss early treatment. Please consult with your veterinarian regarding a diagnostic and treatment plan for Harriet.

What is Dilated Cardiomyopathy, DCM1?

DCM is the most common acquired heart disease of adult dogs. The heart has two heavily muscled ventricles that pump blood away from the heart. This disease causes progressive weakening of the ventricles by reducing the muscle mass, which causes the ventricles to dilate. Dilated ventricles do not contract and circulate oxygenated blood well, which eventually leads to heart failure.

ALT Activity

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Harriet inherited one copy of the variant we tested

Why is this important to your vet?

Harriet has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Harriet has this genotype, as ALT is often used as an indicator of liver health and Harriet is likely to have a lower than average resting ALT activity. As such, an increase in Harriet’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Von Willebrand Disease Type I, Type I vWD (VWF)

Identified in Doberman Pinschers

Deafness and Vestibular Syndrome of Dobermans, DVDob, DINGS (MYO7A)

Identified in Doberman Pinschers

Unilateral Deafness and Vestibular Syndrome (PTPRQ Exon 39, Doberman Pinscher)

Identified in Doberman Pinschers

Narcolepsy (HCRTR2 Intron 4, Doberman Pinscher Variant)

Identified in Doberman Pinschers

Dilated Cardiomyopathy, DCM2 (TTN, Doberman Pinscher Variant 2)

Identified in Doberman Pinschers

Ehlers Danlos (ADAMTS2, Doberman Pinscher Variant)

Identified in Doberman Pinschers

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

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Through Harriet’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

A381

Map

A1a

Freya DSK’s Haplogroup

A1a is the most common maternal lineage among Western dogs. This lineage traveled from the site of dog domestication in Central Asia to Europe along with an early dog expansion perhaps 10,000 years ago. It hung around in European village dogs for many millennia. Then, about 300 years ago, some of the prized females in the line were chosen as the founding dogs for several dog breeds. That set in motion a huge expansion of this lineage. It's now the maternal lineage of the overwhelming majority of Mastiffs, Labrador Retrievers and Gordon Setters. About half of Boxers and less than half of Shar-Pei dogs descend from the A1a line. It is also common across the world among village dogs, a legacy of European colonialism.

A381

Freya DSK’s Haplotype

Part of the large A1a haplogroup, this haplotype occurs most frequently in German Shepherd Dogs, Doberman Pinschers, and Dachshunds.

Shar Pei dogs think A1a is the coolest!

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Harriet inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Harriet is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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