Freddie inherited one copy of the variant we tested
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Genetic Age
Please note that genetic age is different from calendar age. We can now estimate your dog's calendar age with the Embark Age Test.
The genetic age in this report is an estimation of where your dog is in his or her healthspan. Dogs age at very different rates due to a number of genetic and environmental factors. Body size is a strong genetic influence: for example, a seven year old Great Dane is at the start of his golden years, but a seven year old Pomeranian is just learning what "slow down" means. Just within this example, you can see that the old "one doggie year = seven human years" adage isn’t going to work. And yet, knowing your dog’s age is important: it informs what your dog needs as far as food, frequency of veterinary checkups, and exercise. So how do you best determine how old your dog is?
Embark's genetic age feature calculates how old your dog would be if he or she were aging at an average human rate (using humans in the USA as the baseline). So going back to our Dane/Pom example, we'd estimate a seven year old Great Dane at about 80 years old (senior citizen), but a seven year old Pom would be about 42 (adult). Makes way more sense, right?
Calendar age | Genetic age |
---|---|
1 year | 17 human years |
2 years | 25 human years |
3 years | 31 human years |
4 years | 37 human years |
5 years | 44 human years |
6 years | 50 human years |
7 years | 57 human years |
8 years | 63 human years |
9 years | 70 human years |
10 years | 76 human years |
11 years | 83 human years |
All we need from you is a calendar age. It's okay if this is an estimation: it is just a starting point. We then factor in your dog's breed composition, information at certain genes that affect size, and their inbreeding coefficient to calculate genetic age. Like in humans, in dogs females tend to live longer than males (so an “80 year old” female dog = 80 year old woman). Exercise and diet also play a role in how long your dog will live. Nevertheless, genetic age is the primary risk factor for numerous diseases in dogs, including cancer, kidney disease, osteoarthritis, cataracts, cardiac disease and cognitive decline. It can help you and your vet know what you should feed your dog, what screenings to get, and other aspects of your dog’s care.
Wolfiness score
How wolfy is my dog?
Most dogs have wolfiness scores of 1% or less. We find populations and breeds with higher scores of 2-4% occasionally, and unique dogs with scores of 5% or above more rarely.
What it means for my dog
Your dog’s Wolfiness Score is not a measure of recent dog-wolf hybridization and does not necessarily indicate that your dog has some recent wolf ancestors. (If your dog has recent wolf ancestors, you will see that in the breed mix report.) Instead, the Wolfiness Score is based on the number of ancient genetic variants your dog has in our unique Wolfiness marker panel. Wolfiness scores up to 10% are almost always due to ancient wolf genes that survived many generations, rather than any recent wolf ancestors. These ancient genes may be a few thousand years old, or may even date back to the original domestication event 15,000 years ago. They are bits of a wild past that survive in your dog!
The science
Your dog’s Wolfiness Score is based on hundreds of markers across the genome where dogs (or almost all of them) are the same, but wolves tend to be different. These markers are thought to be related to "domestication gene sweeps" where early dogs were selected for some trait. Scientists have known about “domestication gene sweeps” for years, but do not yet know why each sweep occurred. By finding rare dogs carrying an ancient variant at a certain marker, we can make associations with behavior, size, metabolism, and development that likely caused these unique signatures of “doggyness” in the genome.
Predicted Adult Weight
How does weight matter?
For people with puppies, you probably want to know how big of a crate to buy or just how big to expect your dog to become. But genetic weight is also useful for people with fully grown dogs. Just like with people, overweight and obese dogs suffer reduced length and quality of life. They can develop chronic health conditions and suffer from limited mobility and other issues. While over half of American dogs are overweight or obese, fewer than 15% of their owners realize it. By comparing your dog’s weight to their genetic predicted weight you have one more piece of information about their ideal weight. With this and other pieces of information like weight history and body condition, you and your veterinarian may want to discuss your dog’s diet, exercise, and weight control plan to give your pup the longest, healthiest life possible.
How do we predict weight?
Our test is the only dog DNA test that provides true genetic size not based just on breed ancestry but based on over a dozen genes known to influence a dog’s weight. It uses the most advanced science to determine your dog’s expected weight based on their sex, the combination of these genes, and breed-specific modifiers.
How accurate is the predicted weight?
Unlike in people, healthy weight in dogs is controlled largely by only a few genes. Our algorithm explains over 85% of the variance in healthy adult weight. However, due to a few as-yet-undiscovered genes and genetic interactions that affect size, this algorithm sometimes misses. Occasionally it misses by a fairly large amount especially when a dog has a breed with an unknown size-influencing gene. If we have missed your dog’s weight, your dog may be a scientific discovery waiting to happen! Please be sure to go to the Research tab and complete the Getting to know your dog survey, where you can answer questions about your dog’s current weight and body shape. This information will inform our ongoing research into the genetics of size and weight in dogs.
Haplotypes
Revealing your dog’s ancient heritage
Haplotypes are particular DNA sequences that are inherited entirely from a dog’s mom (maternal) or dad (paternal).
Because they are inherited whole, your dog and his or her mom share the exact same maternal haplotype. If you have a male dog, your dog and his dad share the exact same paternal haplotype (female dogs don’t inherit paternal haplotypes).
Because most breeds were started with only a few individual dogs, many breeds are dominated by only one or a few haplotypes.
Haplogroups
Revealing your dog’s ancient heritage
Haplogroups are groups of similar DNA sequences (called haplotypes) that are inherited entirely from the mother (maternal) or father (paternal) and don’t get shuffled up like other parts of your dog’s genome.
These groups all originally descend from one male or female wolf, usually one that lived tens of thousands of years ago. Because they are inherited whole and not shuffled like other DNA, they can be used to trace the ancestral routes that dogs took around the globe en route to your home.
Only male dogs have paternal haplogroups because they are determined by the Y chromosome, which only male dogs have. Both males and females have maternal haplogroups, which come from a part of DNA called the mitochondrial DNA.
Breed analysis
Breed analysis is based on comparing your dog’s DNA with the DNA of dogs from over 350 breeds, types and varieties.How are Freddie's ancestors represented in his DNA?
All dogs are related and share some DNA. Siblings share lots of their DNA (half of it in fact), cousins share a bit less (an eighth), and so on. Because dog breeds are made up of a closed group of dogs, all dogs in that breed share a lot of their DNA, typically about as much as second cousins, though it varies by breed. Different breeds that are closely related share somewhat less DNA, and dogs from very different breeds share even less DNA (but still much more DNA than either dog shares with a cat).
DNA is inherited in pieces, called chromosomes, that are passed along from parent to offspring. Each generation, these chromosomes are broken up and shuffled a bit in a process known as recombination. So, the length of the segments your dog shares with his ancestors decreases with each generation above him: he shares longer segments with his mom than his grandma, longer segments with his grandma than his great-grandma, and so on.
How does Embark know which breeds are in Freddie?
We can use the length of segments Freddie shares with our reference dogs to see how many generations it has been since they last shared an ancestor. Long segments of DNA that are identical to known purebred dogs tell Embark's scientists that Freddie has, without a doubt, a relative from that breed. By testing thousands of genetic markers, we build up his genes one DNA segment at a time, to learn the ancestry with great certainty.
What does this mean for Freddie's looks and behavior?
Look closely and you'll probably find Freddie has some physical and/or behavioral resemblance with his ancestor's breeds. The exact similarity depends on which parts of DNA Freddie shares with each breed. Some traits associated with each breed are listed in the Breed & Ancestry section of our website. Embark will tell you even more about Freddie's traits soon!
P.S. In a small proportion of cases, we find dogs that don’t share segments with other dogs we have tested, indicating the presence of a rare breed that is not part of our reference panel or possibly a true "village dog" without any purebred relatives at all. In these rare cases we contact the owner to find out more and let them know about their unique dog before they get their results. With this in-depth detective work, we are pushing science forward by identifying genetically unique groups of dogs.
Still have questions?
Let us know with our contact form.
What are “Dogs Like Freddie?”
“Dogs Like Freddie” are based on the percentage of breeds the two dogs have in common. For example, two dogs that are both 27% Golden Retriever and 73% Poodle will have a score of 100%. Sometimes dogs with high scores look alike, and sometimes they don’t — either way the comparison is based on each dog’s unique DNA.
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Genetic Breed Result
Labrador Retriever
The Labrador Retriever was bred for hunting and excelled in retrieving game after it was shot down. Known for its gentle disposition and loyalty, the Labrador Retriever has become a favorite of families and breeders alike.
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Start a conversation! Message this dog’s owner.
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Changes to this dog’s profile
- On 8/21/2019 changed name from "Freddie" to "Merakxel Don't Stop Me Now"
Our policy is that each dog’s profile should accurately portray the dog to which the genetic reports belong.
To help ensure adherence to this policy, we show here any changes that have been made to the name or handle (web address) of this dog.
If you believe that this profile is in violation of this policy, you may contact us to report it.
Health Summary
Freddie inherited one variant that you should learn more about.
Progressive Retinal Atrophy, prcd
What does this result mean?
This variant should not impact Freddie’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Freddie is unlikely to develop this condition due to this variant because he only has one copy of the variant.
Impact on Breeding
Your dog carries this variant and will pass it on to ~50% of his offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.
What is Progressive Retinal Atrophy, prcd?
PRA-prcd is a retinal disease that causes progressive, non-painful vision loss. The retina contains cells, called photoreceptors, that collect information about light and send signals to the brain. There are two types of photoreceptors: rods, for night vision and movement, and cones, for day vision and color. This type of PRA leads to early loss of rod cells, leading to night blindness before day blindness.
Breed-Relevant Genetic Conditions
Canine Elliptocytosis (SPTB Exon 30)
Identified in Labrador Retrievers
Variant not detected
Pyruvate Kinase Deficiency (PKLR Exon 7, Labrador Retriever Variant)
Identified in Labrador Retrievers
Variant not detected
Golden Retriever Progressive Retinal Atrophy 2, GR-PRA2 (TTC8)
Identified in Labrador Retrievers
Variant not detected
Progressive Retinal Atrophy, crd4/cord1 (RPGRIP1)
Identified in Labrador Retrievers
Variant not detected
Day Blindness (CNGA3 Exon 7, Labrador Retriever Variant)
Identified in Labrador Retrievers
Variant not detected
Macular Corneal Dystrophy, MCD (CHST6)
Identified in Labrador Retrievers
Variant not detected
Urate Kidney & Bladder Stones (SLC2A9)
Identified in Labrador Retrievers
Variant not detected
Alexander Disease (GFAP)
Identified in Labrador Retrievers
Variant not detected
Degenerative Myelopathy, DM (SOD1A)
Identified in Labrador Retrievers
Variant not detected
Narcolepsy (HCRTR2 Intron 6, Labrador Retriever Variant)
Identified in Labrador Retrievers
Variant not detected
Centronuclear Myopathy, CNM (PTPLA)
Identified in Labrador Retrievers
Variant not detected
Exercise-Induced Collapse, EIC (DNM1)
Identified in Labrador Retrievers
Variant not detected
X-Linked Myotubular Myopathy (MTM1, Labrador Retriever Variant)
Identified in Labrador Retrievers
Variant not detected
Congenital Myasthenic Syndrome, CMS (COLQ, Labrador Retriever Variant)
Identified in Labrador Retrievers
Variant not detected
Hereditary Nasal Parakeratosis, HNPK (SUV39H2)
Identified in Labrador Retrievers
Variant not detected
Skeletal Dysplasia 2, SD2 (COL11A2, Labrador Retriever Variant)
Identified in Labrador Retrievers
Variant not detected
Additional Genetic Conditions
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What is a linkage test?
DNA sequences that are close together on a chromosome tend to be inherited together. Because of this, we can use genetic variation surrounding a specific variant (i.e. "linked" to it) to infer the presence or absence of a variant that is associated with a health condition or trait.
Linkage tests are not as predictive of your dog’s true genotype as direct assays, which we use on most other genetic conditions we test for.
Traits
Explore the genetics behind your dog’s appearance and size.
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Coat Color
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Other Coat Traits
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Other Body Features
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Body Size
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Performance
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Through Freddie’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.
A1a
A382
A1a
A1a is the most common maternal lineage among Western dogs. This lineage traveled from the site of dog domestication in Central Asia to Europe along with an early dog expansion perhaps 10,000 years ago. It hung around in European village dogs for many millennia. Then, about 300 years ago, some of the prized females in the line were chosen as the founding dogs for several dog breeds. That set in motion a huge expansion of this lineage. It's now the maternal lineage of the overwhelming majority of Mastiffs, Labrador Retrievers and Gordon Setters. About half of Boxers and less than half of Shar-Pei dogs descend from the A1a line. It is also common across the world among village dogs, a legacy of European colonialism.
A382
Part of the large A1a haplogroup, this haplotype occurs most frequently in Labrador Retrievers, Golden Retrievers, and Chesapeake Bay Retrievers.
![](http://front.embarkvet.com/img/results/haplodogs/shar-pei-1389564.jpg)
Shar Pei dogs think A1a is the coolest!
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Through Freddie’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.
A2b
Hc.17
A2b
A2b appears to have split a few times in succession, which means that some of the Central Asian male ancestors of this lineage went their separate ways before their respective Y chromosomes made their rounds. There is not much diversity in this lineage, meaning that it has only begun to take off recently. Two iconic breeds, the Dachshund and Bloodhound, represent this lineage well. Over half of Rottweilers are A2b, as are the majority of Labrador Retrievers and Cavalier King Charles Spaniels. While A2a is restricted mostly to East Asia, this paternal line is also found among European breeds.
Hc.17
Part of the A2b haplogroup, this haplotype occurs most frequently in mixed breed dogs.
![](http://front.embarkvet.com/img/results/haplodogs/gromet-1379180-1598x1062.jpg)
A2b is found in the Daschund breed.