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Fixation Of Hope

American Bully

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Genetic Breed Result

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American Bully

100.0% American Bully
American Bully American Bully
The American Bully may look intimidating with its muscular build, but these dogs are bred to be the ideal family or companion dog. This breed is notable for coming in several different size and type varieties, so there's a lot of diversity in their appearance. They're a newer breed, originating in the 80s and 90s in the United States.
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Genetic Stats


Predicted Adult Weight
Genetic Age
27 human years Learn More
Based on the date of birth provided

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Explore by tapping the parents and grandparents.

Our algorithms predict this is the most likely family tree to explain Fixation Of Hope’s breed mix, but this family tree may not be the only possible one.

Health Summary

Fixation Of Hope inherited one variant that you should learn more about.

Neuronal Ceroid Lipofuscinosis 1, Cerebellar Ataxia, NCL4A

Fixation Of Hope inherited one copy of the variant we tested

What does this result mean?

This result should not impact Fixation Of Hope’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring.

What is Neuronal Ceroid Lipofuscinosis 1, Cerebellar Ataxia, NCL4A?

A lysosome is a structure within the cell that digests and removes waste. When the lysosome cannot recycle waste properly, the waste accumulates and causes the cell to die. This form of lysosomal storage disease causes adult onset neurologic signs.

Breed-Relevant Genetic Conditions

Progressive Retinal Atrophy, crd1 (PDE6B)

Identified in American Bullies

Progressive Retinal Atrophy, crd2 (IQCB1)

Identified in American Bullies

Canine Multifocal Retinopathy (BEST1 Exon 2)

Identified in American Bullies

Urate Kidney & Bladder Stones (SLC2A9)

Identified in American Bullies

Neuronal Ceroid Lipofuscinosis 10, NCL 10 (CTSD Exon 5)

Identified in American Bullies

L-2-Hydroxyglutaricaciduria, L2HGA (L2HGDH)

Identified in American Bullies

Ichthyosis (NIPAL4)

Identified in American Bullies

Additional Genetic Conditions


Clinical Tools

Explore the genetics behind your dog’s appearance and size.
Coat Color

Coat Color

E Locus (MC1R)
Can have a melanistic mask (EmE)
K Locus (CBD103)
More likely to have a mostly solid black or brown coat (KBky)
A Locus (ASIP)
Not expressed (ayat)
D Locus (MLPH)
Dark areas of hair and skin are not lightened (Dd)
B Locus (TYRP1)
Black or gray hair and skin (Bb)
Saddle Tan (RALY)
Not expressed (NI)
M Locus (PMEL)
No merle alleles (mm)
Other Coat Traits

Other Coat Traits

Furnishings (RSPO2) LINKAGE
Likely unfurnished (no mustache, beard, and/or eyebrows) (II)
Coat Length (FGF5)
Likely short or mid-length coat (GG)
Shedding (MC5R)
Likely light to moderate shedding (TT)
Coat Texture (KRT71)
Likely straight coat (CC)
Hairlessness (FOXI3) LINKAGE
Very unlikely to be hairless (NN)
Hairlessness (SGK3)
Very unlikely to be hairless (NN)
Oculocutaneous Albinism Type 2 (SLC45A2) LINKAGE
Likely not albino (NN)
Other Body Features

Other Body Features

Muzzle Length (BMP3)
Likely medium or long muzzle (AC)
Tail Length (T)
Likely normal-length tail (CC)
Hind Dewclaws (LMBR1)
Unlikely to have hind dew claws (CC)
Blue Eye Color (ALX4) LINKAGE
Less likely to have blue eyes (NN)
Back Muscling & Bulk, Large Breed (ACSL4)
Likely normal muscling (CC)
Body Size

Body Size

Body Size (IGF1)
Intermediate (NI)
Body Size (IGFR1)
Larger (GG)
Body Size (STC2)
Larger (TT)
Body Size (GHR - E191K)
Larger (GG)
Body Size (GHR - P177L)
Larger (CC)
Performance

Performance

Altitude Adaptation (EPAS1)
Normal altitude tolerance (GG)
Appetite (POMC) LINKAGE
Normal food motivation (NN)

Through Fixation Of Hope’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1d

Haplotype

A248

Map

A1d

Fixation Of Hope’s Haplogroup

This female lineage can be traced back about 15,000 years to some of the original Central Asian wolves that were domesticated into modern dogs. The early females that represent this lineage were likely taken into Eurasia, where they spread rapidly. As a result, many modern breed and village dogs from the Americas, Africa, through Asia and down into Oceania belong to this group! This widespread lineage is not limited to a select few breeds, but the majority of Rottweilers, Afghan Hounds and Wirehaired Pointing Griffons belong to it. It is also the most common female lineage among Papillons, Samoyeds and Jack Russell Terriers. Considering its occurrence in breeds as diverse as Afghan Hounds and Samoyeds, some of this is likely ancient variation. But because of its presence in many modern European breeds, much of its diversity likely can be attributed to much more recent breeding.

A248

Fixation Of Hope’s Haplotype

Part of the large A1d haplogroup, this haplotype has been detected in village dogs in French Polynesia and Colombia. Among breeds, it occurs in Jack Russell Terriers, Fox Terrier Wires, and Cocker Spaniels.

Some other Embark dogs with this haplotype:

The vast majority of Rottweilers have the A1d haplogroup.

The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Fixation Of Hope inherited from her mom and dad? Check out her breed breakdown and family tree.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Fixation Of Hope is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.