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“Izzy”
First Lady's White Rose

Golden Retriever

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Registration

American Kennel Club (AKC):

Genetic Breed Result

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Golden Retriever

Developed as an ideal hunting retriever, the Golden Retriever's eagerness to please and friendliness has made them an extremely popular family pet.

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Health Summary

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Izzy has three variants that you should let your vet know about.

ALT Activity

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Izzy inherited one copy of the variant we tested

Why is this important to your vet?

Izzy has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Izzy has this genotype, as ALT is often used as an indicator of liver health and Izzy is likely to have a lower than average resting ALT activity. As such, an increase in Izzy’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Copper Toxicosis (Attenuating)

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Izzy inherited both copies of the variant we tested

Why is this important to your vet?

Izzy has a genotype at the ATP7A gene that modifies and may help mitigate some of the symptoms from dogs with variants at ATP7B. This variant is not associated with an increased risk of any disease. As this variant resides on the X- chromosome, male dogs with one copy of the variant are better protected from copper accumulation due to the ATP7B variant than female dogs with one copy of the variant.

What is Copper Toxicosis (Attenuating)?

The ATP7A variant is considered beneficial and may be best described as a helpful modifier of the harmful copper toxicosis variant ATP7B. The ATP7A variant may help mitigate some of the symptoms of dogs with variants at ATP7B. Dogs with the ATP7A variant have not been observed to have any beneficial or harmful complications if they have two copies of the normal ATP7B variant.

Copper Toxicosis (Attenuating)

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Izzy inherited one copy of the variant we tested

Why is this important to your vet?

Izzy has a genotype at the RETN gene that modifies and may help mitigate some of the symptoms from dogs with variants at ATP7B. This variant is not associated with an increased risk of any disease.

What is Copper Toxicosis (Attenuating)?

The RETN variant is considered beneficial and may be best described as a helpful modifier of the harmful copper toxicosis variant ATP7B. The RETN variant may help mitigate some of the symptoms of dogs with variants at ATP7B. Dogs with the RETN variant have not been observed to have any beneficial or harmful complications if they have two copies of the normal ATP7B variant.

Breed-Relevant Genetic Conditions

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Progressive Retinal Atrophy, prcd (PRCD Exon 1)

Identified in Golden Retrievers

Golden Retriever Progressive Retinal Atrophy 1, GR-PRA1 (SLC4A3)

Identified in Golden Retrievers

Golden Retriever Progressive Retinal Atrophy 2, GR-PRA2 (TTC8)

Identified in Golden Retrievers

Neuronal Ceroid Lipofuscinosis 5, NCL 5 (CLN5 Exon 4 Deletion, Golden Retriever Variant)

Identified in Golden Retrievers

Degenerative Myelopathy, DM (SOD1A)

Identified in Golden Retrievers

Muscular Dystrophy (DMD, Golden Retriever Variant)

Identified in Golden Retrievers

Congenital Myasthenic Syndrome, CMS (COLQ, Golden Retriever Variant)

Identified in Golden Retrievers

Dystrophic Epidermolysis Bullosa (COL7A1, Golden Retriever Variant)

Identified in Golden Retrievers

Ichthyosis, ICH1 (PNPLA1, Golden Retriever Variant)

Identified in Golden Retrievers

Osteogenesis Imperfecta (COL1A1, Golden Retriever Variant)

Identified in Golden Retrievers

Retina Dysplasia and/or Optic Nerve Hypoplasia (SIX6 Exon 1, Golden Retriever Variant)

Identified in Golden Retrievers

Ichthyosis, ICH2 (ABHD5, Golden Retriever Variant)

Identified in Golden Retrievers

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

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Body Size

Body Size

Performance

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Through Izzy’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

B1

Haplotype

B84

Map

B1

First Lady's White Rose’s Haplogroup

B1 is the second most common maternal lineage in breeds of European or American origin. It is the female line of the majority of Golden Retrievers, Basset Hounds, and Shih Tzus, and about half of Beagles, Pekingese and Toy Poodles. This lineage is also somewhat common among village dogs that carry distinct ancestry from these breeds. We know this is a result of B1 dogs being common amongst the European dogs that their conquering owners brought around the world, because nowhere on earth is it a very common lineage in village dogs. It even enables us to trace the path of (human) colonization: Because most Bichons are B1 and Bichons are popular in Spanish culture, B1 is now fairly common among village dogs in Latin America.

B84

First Lady's White Rose’s Haplotype

Part of the large B1 haplogroup, this haplotype occurs most frequently in Golden Retrievers, Beagles, and Staffordshire Terriers.

The B1 haplogroup can be found in village dogs like the Peruvian Village Dog, pictured above.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Izzy inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Izzy is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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