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“MULOC”
Fiere Muloc van Elegast

Curly-Coated Retriever

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Current Location

The Netherlands

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Registration

N/A : NHSB 3167505

Genetic Breed Result

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Curly-Coated Retriever

Curly-Coated Retrievers are intelligent, hard-working, lovable dogs. These guys are believed to be the first retriever breed. Despite being the original, Curlys are now one of the least common retrievers.

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Health Summary

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MULOC inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Glycogen Storage Disease Type IIIA, GSD IIIA

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MULOC inherited one copy of the variant we tested

What does this result mean?

This result should not impact MULOC’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of his offspring.

What is Glycogen Storage Disease Type IIIA, GSD IIIA?

Glycogen is the form in which our bodies store sugar: they are long, complex molecules that are primarily stored in the liver, heart, kidney, and muscle and are those tissues’ primary source of energy. In GSDs, glycogen accumulates to abnormal levels leading to enlargement and malfunction of these vital organs. Dogs with Type III GSD show milder signs as puppies including lower energy levels and poor weight gain.

ALT Activity

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MULOC inherited both copies of the variant we tested

Why is this important to your vet?

MULOC has two copies of a variant in the GPT gene and is likely to have a lower than average baseline ALT activity. ALT is a commonly used measure of liver health on routine veterinary blood chemistry panels. As such, your veterinarian may want to watch for changes in MULOC's ALT activity above their current, healthy, ALT activity. As an increase above MULOC’s baseline ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Progressive Retinal Atrophy, crd4/cord1 (RPGRIP1)

Identified in Curly-Coated Retrievers

Exercise-Induced Collapse, EIC (DNM1)

Identified in Curly-Coated Retrievers

Additional Genetic Conditions

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Coat Color

Coat Color

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Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through MULOC’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1d

Haplotype

A247

Map

A1d

Fiere Muloc van Elegast’s Haplogroup

This female lineage can be traced back about 15,000 years to some of the original Central Asian wolves that were domesticated into modern dogs. The early females that represent this lineage were likely taken into Eurasia, where they spread rapidly. As a result, many modern breed and village dogs from the Americas, Africa, through Asia and down into Oceania belong to this group! This widespread lineage is not limited to a select few breeds, but the majority of Rottweilers, Afghan Hounds and Wirehaired Pointing Griffons belong to it. It is also the most common female lineage among Papillons, Samoyeds and Jack Russell Terriers. Considering its occurrence in breeds as diverse as Afghan Hounds and Samoyeds, some of this is likely ancient variation. But because of its presence in many modern European breeds, much of its diversity likely can be attributed to much more recent breeding.

A247

Fiere Muloc van Elegast’s Haplotype

Part of the large A1d haplogroup, this common haplotype occurs in village dogs all over the world. Among the 32 breeds we have sampled it in, the most common occurrences include Boxers, Labrador Retrievers, and Papillons.

Some other Embark dogs with this haplotype:

The vast majority of Rottweilers have the A1d haplogroup.

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Through MULOC’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A2b

Haplotype

Hc.17

Map

A2b

Fiere Muloc van Elegast’s Haplogroup

A2b appears to have split a few times in succession, which means that some of the Central Asian male ancestors of this lineage went their separate ways before their respective Y chromosomes made their rounds. There is not much diversity in this lineage, meaning that it has only begun to take off recently. Two iconic breeds, the Dachshund and Bloodhound, represent this lineage well. Over half of Rottweilers are A2b, as are the majority of Labrador Retrievers and Cavalier King Charles Spaniels. While A2a is restricted mostly to East Asia, this paternal line is also found among European breeds.

Hc.17

Fiere Muloc van Elegast’s Haplotype

Part of the A2b haplogroup, this haplotype occurs most frequently in mixed breed dogs.

Some other Embark dogs with this haplotype:

A2b is found in the Daschund breed.

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