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Ellie

French Bulldog

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“Ellie is a blue brindle french bulldog that has everyone wrapped around her little paw. She thinks she is queen of the house and bosses around the big dogs. Her favorite things to do is chase a laser, take naps, and cuddle”

Place of Birth

Springfield, OH, USA

Current Location

Arcanum, Ohio, USA

From

Springfield, OH, USA

This dog has been viewed and been given 3 wags

Registration

American Kennel Club (AKC):

Genetic Breed Result

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French Bulldog

French Bulldogs, affectionately known by their many fans as Frenchies, are an immensely popular and well-known breed of dog. As their name implies, they are native to France and are the result of a mix between English Bulldogs and local dogs in Paris. They are very popular around the world, earning their place as the 4th most popular dog in the United Kingdom and the 9th most popular dog in the United States.

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Breed Reveal Video

Our algorithms predict this is the most likely family tree to explain Ellie’s breed mix, but this family tree may not be the only possible one.

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Health Summary

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Ellie is at increased risk for one genetic health condition.

And inherited two variants that you should learn more about.

Intervertebral Disc Disease (Type I)

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Ellie inherited both copies of the variant we tested

How to interpret this result

Ellie has two copies of an FGF4 retrogene on chromosome 12. In some breeds such as Beagles, Cocker Spaniels, and Dachshunds (among others) this variant is found in nearly all dogs. While those breeds are known to have an elevated risk of IVDD, many dogs in those breeds never develop IVDD. For mixed breed dogs and purebreds of other breeds where this variant is not as common, risk for Type I IVDD is greater for individuals with this variant than for similar dogs.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

Degenerative Myelopathy, DM

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Ellie inherited both copies of the variant we tested

What does this result mean?

Our research indicates that this genetic variant is not likely to increase the risk that Ellie will develop this disease.

Scientific Basis

Dogs with similar breeds to Ellie are not likely to have increased risk of developing the disease. Research has indicated increased risk in other breeds that are not found in Ellie.

What is Degenerative Myelopathy, DM?

The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.

ALT Activity

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Ellie inherited one copy of the variant we tested

Why is this important to your vet?

Ellie has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Ellie has this genotype, as ALT is often used as an indicator of liver health and Ellie is likely to have a lower than average resting ALT activity. As such, an increase in Ellie’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Progressive Retinal Atrophy, crd4/cord1

Identified in French Bulldogs

Canine Multifocal Retinopathy, cmr1

Identified in French Bulldogs

Urate Kidney & Bladder Stones

Identified in French Bulldogs

Additional Genetic Conditions

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Base Coat Color

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Coat Color Modifiers

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Through Ellie’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1b

Haplotype

A390

Map

A1b

Ellie’s Haplogroup

This female lineage was very likely one of the original lineages in the wolves that were first domesticated into dogs in Central Asia about 15,000 years ago. Since then, the lineage has been very successful and travelled the globe! Dogs from this group are found in ancient Bronze Age fossils in the Middle East and southern Europe. By the end of the Bronze Age, it became exceedingly common in Europe. These dogs later became many of the dogs that started some of today's most popular breeds, like German Shepherds, Pugs, Whippets, English Sheepdogs and Miniature Schnauzers. During the period of European colonization, the lineage became even more widespread as European dogs followed their owners to far-flung places like South America and Oceania. It's now found in many popular breeds as well as village dogs across the world!

A390

Ellie’s Haplotype

Part of the A1b haplogroup, this haplotype occurs most frequently in mixed breed dogs.

Some other Embark dogs with this haplotype:

A1b is the most common haplogroup found in German Shepherds.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Ellie inherited from her mom and dad? Check out her breed breakdown and family tree.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Ellie is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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