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Edward

Mixed Ancestry

“I adopted my good boy Edward when he was 2 months old from a breeder at Centerfire Kennel in KY. He is a very smart dog and quickly learned many dog tricks and basic commands. He still knows them including play dead, turn around, roll over, high five, gimme ten, crawl, nose touch, stay, and handshake. When he was younger, he loved to play fetch and swim in rivers and lakes. In August 2022, he was diagnosed with multicentric lymphoma. Edward crossed the rainbow bridge on July 2023.🌈💔🥹”

Place of Birth

West Liberty, Kentucky, USA

Current Location

Miami, Florida, USA

From

West Liberty, Kentucky, USA

This dog has been viewed and been given 64 wags

Genetic Breed Result

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Beagle

The Beagle is a scent hound and a great family pet. They are known for being affectionate and having loud voices.

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Russell-type Terrier

These small, energetic terriers, developed in 19th century England for hunting small game, are now some of the best agility dogs around.

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Dogs Like Edward

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Discover dogs who share a similar breed mix to Edward. A higher score means the two dogs have more of their breed mix in common. A score of 100% means they share the exact same breed mix!

Click or tap on a pic to learn more about each dog and see an in-depth comparison of their DNA, breeds, and more.

DNA Breed Origins

Breed colors:
Beagle
Russell-type Terrier

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Changes to this dog’s profile
  • On 7/14/2023 changed handle from "edward107" to "edward_the_jackabee"
  • On 4/14/2023 changed handle from "edward6" to "edward107"
Here’s what Edward’s family tree may have looked like.
While there may be other possible configurations of his family’s relationships, this is the most likely family tree to explain Edward’s breed mix.
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Health Summary

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Edward is at increased risk for one genetic health condition.

And inherited two variants that you should learn more about.

Intervertebral Disc Disease (Type I)

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Edward inherited one copy of the variant we tested

How to interpret this result

Edward has one copy of an FGF4 retrogene on chromosome 12. In some breeds such as Beagles, Cocker Spaniels, and Dachshunds (among others) this variant is found in nearly all dogs. While those breeds are known to have an elevated risk of IVDD, many dogs in those breeds never develop IVDD. For mixed breed dogs and purebreds of other breeds where this variant is not as common, risk for Type I IVDD is greater for individuals with this variant than for similar dogs.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

Progressive Retinal Atrophy, crd4/cord1

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Edward inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Edward’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Edward is unlikely to develop this condition due to this variant because he only has one copy of the variant.

What is Progressive Retinal Atrophy, crd4/cord1?

PRA-CRD4/cord1 is a retinal disease that causes progressive, non-painful vision loss over a 1-2 year period. The retina contains cells, called photoreceptors, that collect information about light and send signals to the brain. There are two types of photoreceptors: rods, for night vision and movement, and cones, for day vision and color. This type of PRA leads to early loss of cone cells, causing day blindness before night blindness.

ALT Activity

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Edward inherited one copy of the variant we tested

Why is this important to your vet?

Edward has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Edward has this genotype, as ALT is often used as an indicator of liver health and Edward is likely to have a lower than average resting ALT activity. As such, an increase in Edward’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Factor VII Deficiency

Identified in Beagles

Pyruvate Kinase Deficiency

Identified in Beagles

Severe Combined Immunodeficiency, SCID

Identified in Russell-type Terriers

Primary Open Angle Glaucoma

Identified in Beagles

Primary Lens Luxation

Identified in Russell-type Terriers

Urate Kidney & Bladder Stones

Identified in Russell-type Terriers

Neonatal Cerebellar Cortical Degeneration

Identified in Beagles

Late Onset Spinocerebellar Ataxia

Identified in Russell-type Terriers

Spinocerebellar Ataxia with Myokymia and/or Seizures

Identified in Russell-type Terriers

Degenerative Myelopathy, DM

Identified in Russell-type Terriers

Hypocatalasia, Acatalasemia

Identified in Beagles

Cobalamin Malabsorption

Identified in Beagles

Musladin-Lueke Syndrome, MLS

Identified in Beagles

Osteogenesis Imperfecta

Identified in Beagles

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Base Coat Color

Base Coat Color

Coat Color Modifiers

Coat Color Modifiers

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Through Edward’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

B1

Haplotype

B6/8/67

Map

B1

Edward’s Haplogroup

B1 is the second most common maternal lineage in breeds of European or American origin. It is the female line of the majority of Golden Retrievers, Basset Hounds, and Shih Tzus, and about half of Beagles, Pekingese and Toy Poodles. This lineage is also somewhat common among village dogs that carry distinct ancestry from these breeds. We know this is a result of B1 dogs being common amongst the European dogs that their conquering owners brought around the world, because nowhere on earth is it a very common lineage in village dogs. It even enables us to trace the path of (human) colonization: Because most Bichons are B1 and Bichons are popular in Spanish culture, B1 is now fairly common among village dogs in Latin America.

B6/8/67

Edward’s Haplotype

Part of the large B1 haplogroup, this common haplotype occurs in village dogs from South America to the Middle East, all the way down to the French Polynesian Islands. Among the 12 breed dogs we have seen it in, it occurs most frequently among German Shepherd Dogs, English Springer Spaniels, and Havanese.

The B1 haplogroup can be found in village dogs like the Peruvian Village Dog, pictured above.

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Through Edward’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

D

Haplotype

H7

Map

D

Edward’s Haplogroup

The D paternal lineage is very common in well-known populations of dogs. Breeds belonging to the D lineage likely have direct male ancestors that can be traced all the way back to the origin of domestic dogs themselves! One popular breed that commonly sports a D lineage is the Boxer. Boxers were developed in the late 19th century from Mastiff dogs, so it is no surprise that D is well represented among Mastiffs, Bulldogs, as well as Terriers. Intriguingly, D is also found among Lhasa Apsos, an ancient Tibetan breed, and Afghan Hounds. While the presence of this lineage in Polynesia or the New World can be chalked up to interbreeding with European dogs brought during voyages of discovery or later settlement, D is also well represented among village dog populations in the Middle East and Africa. If the fact that we find dogs bearing a D lineage in the Middle East (not to mention the large amount of diversity among Middle Eastern D lineage males) is any indication of ancient residence in that region, then the presence among Oceanian village dogs is peculiar. Rather, it may be that D is part of a broader Eurasian group of ancient paternal lineages which disappeared from the eastern portion of its original range, persisting in the island of New Guinea as well as West Asia and Africa. With the rise of Mastiff breeds, the D lineage received a new life as it became common among many types of working dogs.

H7

Edward’s Haplotype

Part of the D haplogroup, this common haplotype has been found in French Bulldogs, Afghan Hounds, Bull Terriers, and village dogs spanning from South America to Africa and into the South Pacific.

The D paternal lineage is common in Boxers.

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