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“Cedric”
Ebonheart’s Mischief Not Managed

Papillon

“Cedric is a goofy, hyper and very smart little guy. He comes from Swedish Champion lines and he is AKC and UKC registered.”

Current Location

Des Moines, Iowa, USA

This dog has been viewed and been given 6 wags

Registration

American Kennel Club (AKC):

Genetic Breed Result

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Papillon

The Papillon, also called the Continental Toy Spaniel, is a breed of dog of the Spaniel type.

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Changes to this dog’s profile
  • On 9/24/2019 changed name from "Ebonheart’s Mischief Bot Managed" to "Ebonheart’s Mischief Not Managed"
  • On 9/24/2019 changed name from "Silvermorning’s Icon" to "Ebonheart’s Mischief Bot Managed"
  • On 3/6/2019 changed handle from "silvermorningsicon" to "ebonheartscedric"

Health Summary

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Cedric is at increased risk for one genetic health condition.

And inherited two variants that you should learn more about.

Intervertebral Disc Disease (Type I)

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Cedric inherited both copies of the variant we tested

What does this result mean?

Follow-up by our experts indicates that this genetic variant is associated with an increase to Cedric’s risk for developing Intervertebral Disc Disease (Type I).

Scientific Basis

Research studies for this variant have been based on dogs of other breeds. While dogs with similar breeds to Cedric have not yet been the focus of research studies, our data indicates that Cedric is likely to be at increased risk.

Impact on Breeding

While further investigation is warranted to determine the clinical presentation and penetrance in Cedric’s breed, we recommend taking this genetic result into account when making breeding decisions.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

Factor VII Deficiency

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Cedric inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Cedric’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Cedric is unlikely to develop this condition due to this variant because he only has one copy of the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of his offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Factor VII Deficiency?

Factor VII deficiency is a type of coagulopathy, a disorder of blood clotting. It is characterized by mild to moderate abnormal bleeding (generally less severe than that caused by deficiencies in other clotting factors such as Factors VIII or IX). Some dogs with this condition will show no clinical signs.

ALT Activity

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Cedric inherited one copy of the variant we tested

Why is this important to your vet?

Cedric has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Cedric has this genotype, as ALT is often used as an indicator of liver health and Cedric is likely to have a lower than average resting ALT activity. As such, an increase in Cedric’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Von Willebrand Disease Type I, Type I vWD (VWF)

Identified in Papillons

Progressive Retinal Atrophy, PRA1 (CNGB1)

Identified in Papillons

Progressive Retinal Atrophy, crd4/cord1 (RPGRIP1)

Identified in Papillons

Additional Genetic Conditions

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Traits

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Coat Color

Coat Color

Other Coat Traits

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Through Cedric’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1d

Haplotype

A426

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A1d

Ebonheart’s Mischief Not Managed’s Haplogroup

This female lineage can be traced back about 15,000 years to some of the original Central Asian wolves that were domesticated into modern dogs. The early females that represent this lineage were likely taken into Eurasia, where they spread rapidly. As a result, many modern breed and village dogs from the Americas, Africa, through Asia and down into Oceania belong to this group! This widespread lineage is not limited to a select few breeds, but the majority of Rottweilers, Afghan Hounds and Wirehaired Pointing Griffons belong to it. It is also the most common female lineage among Papillons, Samoyeds and Jack Russell Terriers. Considering its occurrence in breeds as diverse as Afghan Hounds and Samoyeds, some of this is likely ancient variation. But because of its presence in many modern European breeds, much of its diversity likely can be attributed to much more recent breeding.

A426

Ebonheart’s Mischief Not Managed’s Haplotype

Part of the A1d haplogroup, this haplotype occurs most frequently in mixed-breed dogs.

The vast majority of Rottweilers have the A1d haplogroup.

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Through Cedric’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

H1a.53

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A1a

Ebonheart’s Mischief Not Managed’s Haplogroup

Some of the wolves that became the original dogs in Central Asia around 15,000 years ago came from this long and distinguished line of male dogs. After domestication, they followed their humans from Asia to Europe and then didn't stop there. They took root in Europe, eventually becoming the dogs that founded the Vizsla breed 1,000 years ago. The Vizsla is a Central European hunting dog, and all male Vizslas descend from this line. During the Age of Exploration, like their owners, these pooches went by the philosophy, "Have sail, will travel!" From the windy plains of Patagonia to the snug and homey towns of the American Midwest, the beaches of a Pacific paradise, and the broad expanse of the Australian outback, these dogs followed their masters to the outposts of empires. Whether through good fortune or superior genetics, dogs from the A1a lineage traveled the globe and took root across the world. Now you find village dogs from this line frolicking on Polynesian beaches, hanging out in villages across the Americas, and scavenging throughout Old World settlements. You can also find this "prince of patrilineages" in breeds as different as German Shepherds, Golden Retrievers, Pugs, Border Collies, Scottish Terriers, and Irish Wolfhounds. No male wolf line has been as successful as the A1a line!

H1a.53

Ebonheart’s Mischief Not Managed’s Haplotype

Part of the A1a haplogroup, this haplotype occurs most frequently in Golden Retrievers, Border Collies, and the Coton de Tulear.

Dogs with A1a lineage travelled during European Colonial times.

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