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EAK'S Yellow Jacket

Alapaha Blue Blood Bulldog

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Registration

Alapaha Bulldog Registry (ABR): ABR-000

Genetic Breed Result

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Alapaha Blue Blood Bulldog

The Alapaha Blue Blood Bulldog is a bulldog type breed that was developed in the southern part of the United States as a catch dog.

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Health Summary

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EAK'S Yellow Jacket inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Factor VII Deficiency

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EAK'S Yellow Jacket inherited one copy of the variant we tested

What does this result mean?

This variant should not impact EAK'S Yellow Jacket’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. EAK'S Yellow Jacket is unlikely to develop this condition due to this variant because he only has one copy of the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of his offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Factor VII Deficiency?

Factor VII deficiency is a type of coagulopathy, a disorder of blood clotting. It is characterized by mild to moderate abnormal bleeding (generally less severe than that caused by deficiencies in other clotting factors such as Factors VIII or IX). Some dogs with this condition will show no clinical signs.

ALT Activity

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EAK'S Yellow Jacket inherited one copy of the variant we tested

Why is this important to your vet?

EAK'S Yellow Jacket has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that EAK'S Yellow Jacket has this genotype, as ALT is often used as an indicator of liver health and EAK'S Yellow Jacket is likely to have a lower than average resting ALT activity. As such, an increase in EAK'S Yellow Jacket’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Progressive Retinal Atrophy, crd1 (PDE6B, American Staffordshire Terrier Variant)

Identified in Alapaha Blue Blood Bulldogs

Progressive Retinal Atrophy, crd2 (IQCB1)

Identified in Alapaha Blue Blood Bulldogs

Canine Multifocal Retinopathy, cmr1 (BEST1 Exon 2)

Identified in Alapaha Blue Blood Bulldogs

Urate Kidney & Bladder Stones (SLC2A9)

Identified in Alapaha Blue Blood Bulldogs

Neuronal Ceroid Lipofuscinosis, Cerebellar Ataxia, NCL4A (ARSG Exon 2, American Staffordshire Terrier Variant)

Identified in Alapaha Blue Blood Bulldogs

Neuronal Ceroid Lipofuscinosis 10, NCL 10 (CTSD Exon 5, American Bulldog Variant)

Identified in Alapaha Blue Blood Bulldogs

L-2-Hydroxyglutaricaciduria, L2HGA (L2HGDH, Staffordshire Bull Terrier Variant)

Identified in Alapaha Blue Blood Bulldogs

Ichthyosis (NIPAL4, American Bulldog Variant)

Identified in Alapaha Blue Blood Bulldogs

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

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Through EAK'S Yellow Jacket’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

A17

Map

A1a

EAK'S Yellow Jacket’s Haplogroup

A1a is the most common maternal lineage among Western dogs. This lineage traveled from the site of dog domestication in Central Asia to Europe along with an early dog expansion perhaps 10,000 years ago. It hung around in European village dogs for many millennia. Then, about 300 years ago, some of the prized females in the line were chosen as the founding dogs for several dog breeds. That set in motion a huge expansion of this lineage. It's now the maternal lineage of the overwhelming majority of Mastiffs, Labrador Retrievers and Gordon Setters. About half of Boxers and less than half of Shar-Pei dogs descend from the A1a line. It is also common across the world among village dogs, a legacy of European colonialism.

A17

EAK'S Yellow Jacket’s Haplotype

Part of the large A1a haplogroup, this common haplotype is found in village dogs across the globe. Among breed dogs, we find it most frequently in Labrador Retrievers, Boxers, and Mastiffs.

Shar Pei dogs think A1a is the coolest!

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Through EAK'S Yellow Jacket’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

H1a.7/H1a.8

Map

A1a

EAK'S Yellow Jacket’s Haplogroup

Some of the wolves that became the original dogs in Central Asia around 15,000 years ago came from this long and distinguished line of male dogs. After domestication, they followed their humans from Asia to Europe and then didn't stop there. They took root in Europe, eventually becoming the dogs that founded the Vizsla breed 1,000 years ago. The Vizsla is a Central European hunting dog, and all male Vizslas descend from this line. During the Age of Exploration, like their owners, these pooches went by the philosophy, "Have sail, will travel!" From the windy plains of Patagonia to the snug and homey towns of the American Midwest, the beaches of a Pacific paradise, and the broad expanse of the Australian outback, these dogs followed their masters to the outposts of empires. Whether through good fortune or superior genetics, dogs from the A1a lineage traveled the globe and took root across the world. Now you find village dogs from this line frolicking on Polynesian beaches, hanging out in villages across the Americas, and scavenging throughout Old World settlements. You can also find this "prince of patrilineages" in breeds as different as German Shepherds, Golden Retrievers, Pugs, Border Collies, Scottish Terriers, and Irish Wolfhounds. No male wolf line has been as successful as the A1a line!

H1a.7/H1a.8

EAK'S Yellow Jacket’s Haplotype

Part of the large A1a haplogroup, this very common haplotype occurs in village dogs throughout the world (including southeast Asia, which is uncommon for A1a’s). Among the 25 breeds we see this haplotype in, it occurs most frequently in Labrador Retriever, Vizsla, and English Springer Spaniel.

Dogs with A1a lineage travelled during European Colonial times.

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