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“MIDNA”
CHAMPION AKC GRAND CH EAK'S Twilight Princess

Alapaha Blue Blood Bulldog

“Twilight Princess was born and bred here at Eclipse Kennel”

This dog has been viewed and been given 3 wags

Registration

Alapaha Bulldog Registry (ABR): A01-5031

Genetic Breed Result

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Alapaha Blue Blood Bulldog

The Alapaha Blue Blood Bulldog is a bulldog type breed that was developed in the southern part of the United States as a catch dog.

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Health Summary

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MIDNA inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Dilated Cardiomyopathy, DCM1

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MIDNA inherited one copy of the variant we tested

What does this result mean?

Research indicates that this genetic variant is not likely to increase the risk that MIDNA will develop this condition.

Scientific Basis

Dogs with MIDNA’s breed have been included in research studies or have had follow-up by our experts that indicate that this genetic variant is not likely to increase the risk of MIDNA developing clinical disease.

Impact on Breeding

This genetic result should not be the primary factor in your breeding decisions.

What is Dilated Cardiomyopathy, DCM1?

DCM is the most common acquired heart disease of adult dogs. The heart has two heavily muscled ventricles that pump blood away from the heart. This disease causes progressive weakening of the ventricles by reducing the muscle mass, which causes the ventricles to dilate. Dilated ventricles do not contract and circulate oxygenated blood well, which eventually leads to heart failure.

ALT Activity

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MIDNA inherited one copy of the variant we tested

Why is this important to your vet?

MIDNA has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that MIDNA has this genotype, as ALT is often used as an indicator of liver health and MIDNA is likely to have a lower than average resting ALT activity. As such, an increase in MIDNA’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Progressive Retinal Atrophy, crd1 (PDE6B, American Staffordshire Terrier Variant)

Identified in Alapaha Blue Blood Bulldogs

Progressive Retinal Atrophy, crd2 (IQCB1)

Identified in Alapaha Blue Blood Bulldogs

Canine Multifocal Retinopathy, cmr1 (BEST1 Exon 2)

Identified in Alapaha Blue Blood Bulldogs

Hereditary Cataracts (HSF4 Exon 9, Boston Terrier Variant)

Identified in Alapaha Blue Blood Bulldogs

Urate Kidney & Bladder Stones (SLC2A9)

Identified in Alapaha Blue Blood Bulldogs

Neuronal Ceroid Lipofuscinosis, Cerebellar Ataxia, NCL4A (ARSG Exon 2, American Staffordshire Terrier Variant)

Identified in Alapaha Blue Blood Bulldogs

Neuronal Ceroid Lipofuscinosis 10, NCL 10 (CTSD Exon 5, American Bulldog Variant)

Identified in Alapaha Blue Blood Bulldogs

L-2-Hydroxyglutaricaciduria, L2HGA (L2HGDH, Staffordshire Bull Terrier Variant)

Identified in Alapaha Blue Blood Bulldogs

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through MIDNA’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

A17

Map

A1a

EAK'S Twilight Princess’s Haplogroup

A1a is the most common maternal lineage among Western dogs. This lineage traveled from the site of dog domestication in Central Asia to Europe along with an early dog expansion perhaps 10,000 years ago. It hung around in European village dogs for many millennia. Then, about 300 years ago, some of the prized females in the line were chosen as the founding dogs for several dog breeds. That set in motion a huge expansion of this lineage. It's now the maternal lineage of the overwhelming majority of Mastiffs, Labrador Retrievers and Gordon Setters. About half of Boxers and less than half of Shar-Pei dogs descend from the A1a line. It is also common across the world among village dogs, a legacy of European colonialism.

A17

EAK'S Twilight Princess’s Haplotype

Part of the large A1a haplogroup, this common haplotype is found in village dogs across the globe. Among breed dogs, we find it most frequently in Labrador Retrievers, Boxers, and Mastiffs.

Shar Pei dogs think A1a is the coolest!

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that MIDNA inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since MIDNA is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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