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Drax

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“Drax is a lovable confident happy dogo”

Instagram tag
@drax_and_mira

Place of birth
Shell Knob, MO, USA
From
Shell Knob, MO, USA

This dog has been viewed 47 times and been given 1 wag

Genetic Breed Result

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38.8% German Shepherd Dog
28.0% Siberian Husky
18.3% Alaskan Malamute
10.9% Gray Wolf
4.0% Samoyed
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Genetic Stats

Wolfiness: 13.3 % HIGH Learn More
Predicted Adult Weight: 81 lbs Learn More
Genetic Age: 14 human years Learn More

DNA Breed Origins

What’s this?
Breed colors:
German Shepherd Dog
Siberian Husky
Alaskan Malamute
Gray Wolf
Samoyed

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Health

Traits

Maternal Haplotype

Paternal Haplotype

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Summary

0
AT RISK
1
CARRIER
167
CLEAR
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Clinical traits

These genetic traits are valuable to your veterinarian and can inform the clinical decisions and diagnoses they make.

Alanine Aminotransferase Activity result: Low Normal
This result helps your vet understand what your dog's baseline ALT activity is. The enzyme alanine aminotransferase, or ALT, is commonly used to evaluate liver health. Do…
Drax has one copy of a mutation associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Drax has this …

Not At Risk

Good news! Drax did not test positive for any of the genetic diseases that Embark screens for. Read on to learn more about the conditions we test for, but rest assured that Drax does not have the mutations known to cause them.

It is still important to let your veterinarian know these results because they could help guide Drax’s diagnosis and treatment if he gets sick in the future. Many other diseases caused by environmental factors or undiscovered genetic variants can cause symptoms similar to diseases we test for. By ruling out these mutations, your veterinarian will be able to find the true cause more quickly. Your veterinarian will also know they can safely prescribe medications some dogs are sensitive to.

Carrier for 1 genetic condition

Drax is a carrier for 1 of the genetic diseases that Embark tests for.
What does Carrier mean?

Drax has inherited a recessive allele for a genetic trait or mutation. This is not enough to cause symptoms of the disease, but is important to bear in mind if Drax ever has children.

Condition List

2,8-Dihydroxyadenine (2,8-DHA) Urolithiasis
(APRT)
Kidney and Bladder

Best characterized in the Native American Indian Dog, this condition causes 2,8-dihydroxyadenine (2,8-DHA) kidney and bladder stones: if caught early, it can be medically…

Common Conditions

Good news! Drax tested clear for 14 genetic conditions that are common in his breed mix.
Condition List

MDR1 Drug Sensitivity
(MDR1)
Clinical

Sensitivity to certain classes of drugs, notably the parasiticide ivermectin, as well as certain gastroprotectant and anti-cancer medications, occurs in dogs with mutatio…

Seen in German Shepherd Dogs, but not Drax.

Factor VII Deficiency
(F7 Exon 5)
Blood

Coagulopathies, disorders of blood clotting, can lead to symptoms such as easy bruising or bleeding. Dogs with coagulopathies are often at risk for excessive bleeding dur…

Seen in Alaskan Malamutes, but not Drax.

Factor VIII Deficiency, Hemophilia A
(F8 Exon 11, Shepherd Variant 1)
Blood

Coagulopathies, disorders of blood clotting, can lead to symptoms such as easy bruising or bleeding. Dogs with coagulopathies are often at risk for excessive bleeding dur…

Seen in German Shepherd Dogs, but not Drax.

Factor VIII Deficiency, Hemophilia A
(F8 Exon 1, Shepherd Variant 2)
Blood

Coagulopathies, disorders of blood clotting, can lead to symptoms such as easy bruising or bleeding. Dogs with coagulopathies are often at risk for excessive bleeding dur…

Seen in German Shepherd Dogs, but not Drax.

Canine Leukocyte Adhesion Deficiency Type III (LAD3)
(FERMT3)
Blood

A rare disorder of white blood cells, this causes increased susceptibility to infections and bleeding tendencies. Affected dogs present with a history of persistent skin …

Seen in German Shepherd Dogs, but not Drax.

Achromatopsia
(CNGA3 Exon 7 German Shepherd Variant)
Eyes

This is a progressive, nonpainful disorder of the retina that affects color vision and light perception. Cone cells not only register color, they allow the dog to adjust …

Seen in German Shepherd Dogs, but not Drax.

X-Linked Hereditary Nephropathy (Samoyed Variant 2)
(COL4A5 Exon 35)
Kidney and Bladder

This condition causes inappropriate loss of protein in the urine, which leads to muscle wasting, abnormal fluid accumulation in the skin and limbs, and excessive thirst a…

Seen in Samoyeds, but not Drax.

X-linked Ectodermal Dysplasia, Anhidrotic Ectodermal Dysplasia
(EDA Intron 8)
Multisystem

This developmental condition can cause a scanty haircoat, malformed teeth, and few or absent sweat glands. Because dogs only have sweat glands on their paw pads, they are…

Seen in German Shepherd Dogs, but not Drax.

Renal Cystadenocarcinoma and Nodular Dermatofibrosis (RCND)
(FLCN Exon 7)
Multisystem

A multiorgan syndrome best described in the German Shepherd Dog, affected dogs display thick skin nodules and signs of kidney disease, and should be evaluated by a veteri…

Seen in German Shepherd Dogs, but not Drax.

Mucopolysaccharidosis Type VII, Sly Syndrome
(GUSB Exon 3)
Multisystem

A type of lysosomal storage disease, this can cause skeletal abnormalities, growth retardation, and gait abnormalities, and can require close monitoring and special measu…

Seen in German Shepherd Dogs, but not Drax.

GM1 Gangliosidosis
(GLB1 Exon 15 Alaskan Husky Variant)
Multisystem

An early onset form of lysosomal storage disease, this can cause affected dogs to display neurologic signs as puppies or young adults. These include partial or total visi…

Seen in Siberian Huskys, but not Drax.

Degenerative Myelopathy
(SOD1A)
Brain and Spinal Cord

A disease of mature dogs, this is a progressive degenerative disorder of the spinal cord that can cause muscle wasting and gait abnormalities. Affected dogs do not usuall…

Seen in German Shepherd Dogs, Siberian Huskys, Alaskan Malamutes, Gray Wolfs, Samoyeds, but not Drax.

Polyneuropathy, NDRG1 Malamute Variant
(NDRG1 Exon 4)
Brain and Spinal Cord

Polyneuropathy is a progressive neurologic disease that causes peripheral nerve dysfution. Peripheral nerves relay messages between the brain and spinal cord to the rest …

Seen in Alaskan Malamutes, but not Drax.

Malignant Hyperthermia
(RYR1)
Metabolic

This condition only manifests if affected dogs are treated with certain inhalant anesthetics, and can cause uncontrollable muscle contractions and a dangerous increase in…

Seen in German Shepherd Dogs, Siberian Huskys, Alaskan Malamutes, Gray Wolfs, Samoyeds, but not Drax.

Other Conditions: Clear of 153

Drax is clear of 153 other genetic diseases that Embark tests for.

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Traits

Maternal Haplotype

Paternal Haplotype

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Coat Color

A number of genes are known to affect coat color in dogs, and they all interact. In some cases, other genetic effects may also influence color and pattern.

Trait
Result
 
E Locus (Mask, Grizzle, Recessive Red)
EE
K Locus (Dominant Black)
kyky
A Locus (Agouti, Sable)
awaw
D Locus (Dilute, Blue, Fawn)
DD
B Locus (Brown, Chocolate, Liver, Red)
BB

Other Embark dogs with these Coat Color genes:

Other Coat Traits

Furnishings, shedding and curls are all genetic! And they all interact, too. In fact, the combination of these genes explains the coat phenotypes of 90% of AKC registered dog breeds.

Trait
Result
 
Furnishings / Improper Coat (RSPO2)
II
Long Haircoat (FGF5)
GT
Shedding (MC5R)
CC
Curly Coat (KRT71)
CC
Hairlessness (FOXI3)
LINKAGE
N/N

More information on coat type genetics: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897713/figure/F3/

Other Embark dogs with these Coat Traits genes:

Other Body Features

Trait
Result
 
Brachycephaly (BMP3)
CC
Natural Bobtail (T)
CC
Hind Dewclaws (LMBR1)
CC
Blue Eye Color
LINKAGE
N/N

Body Size

Body size is a complex trait that is affected by both genetic and environmental variation. Our genetic analysis includes genes that, together, explain over 80% of the variation in dog body size. It does not account for runting or stunting; nor does it account for the interactions between various genes both known and unknown.

Trait
Result
 
Body Size - IGF1
NN
Body Size - IGF1R
GG
Body Size - STC2
TT
Body Size - GHR (E195K)
GG
Body Size - GHR (P177L)
CC

Other Embark dogs with these Body Size genes:

Performance

Trait
Result
 
Altitude Adaptation (EPAS1)
GG

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Health

Maternal Haplotype

Paternal Haplotype

Through Drax’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A2

Haplotype

A29a

Map

A2

Drax’s Haplogroup

A2 is a very ancient maternal line. Most likely it was one of the major female lines that contributed to the very first domesticated dogs in Central Asia about 15,000 years ago. Some of the line stayed in Central Asia to the present day, and frequently appear as Tibetan Mastiffs and Akitas. Those that escaped the mountains of Central Asia sought out other cold spots, and are now found among Alaskan Malamutes and Siberian Huskies. This lineage is also occasionally found in several common Western breeds, such as German Shepherds and Labrador Retrievers. Curiously, all New Guinea Singing Dogs descend from this line. These are an ancient and very interesting breed found in the mountains of Papua New Guinea. Unfortunately, they are now endangered. They are closely related to the Australian dingo, so you could say its cousins are dingos! This line is also common in village dogs in Southeast and East Asia. Unlike many other lineages, A2 did not spread across the whole world, probably because it did not have the opportunity to hitch its wagon to European colonialism - or because these dogs just prefer hanging out in mountains, tundras, islands, and other hard-to-reach places!

A29a

Drax’s Haplotype

Part of the A2 haplogroup, this haplotype occurs most commonly in Siberian Huskies, Alaskan Malamutes, Labrador Retrievers, and village dogs from Alaska.

Some other Embark dogs with this haplotype:

Dingos commonly possess this haplogroup.

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Health

Traits

Paternal Haplotype

Through Drax’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

F

Haplotype

H9

Map

F

Drax’s Haplogroup

F is the odd duck in the family of domestic dog male lineages. This paternal lineage is genetically closer to wolves, foxes, and jackals than to other dogs. This indicates that it came into the dog population after dogs were originally domesticated, when one particularly attractive male wolf mated with a female dog, over 6,000 years ago. Since then, these dogs found their way into Africa and Mongolia. It hasn't been found outside those areas except in Basenjis. Basenjis are an iconic African breed, that first made its way to the USA in the early 20th century when a handful of individuals were imported from the Congo. The Basenji is an ancient breed which is distantly related to other dog breeds (most of which are European or Asian), and it has the earliest separation date from all other breed populations. Unsurprisingly, the F lineage has also been found in African village dogs, as well as, surprisingly, some samples from Mongolia. The fact the lineage is found in two very distant places is evidence that it entered the dog population many thousands of years ago.

H9

Drax’s Haplotype

A member of the F haplogroup, this haplotype is found in Basenjis and village dogs throughout Africa.

Some other Embark dogs with this haplotype:

Congo Dogs in Africa commonly have this hapgloroup.

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Health

Traits

Maternal Haplotype