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“Leilani”
CH TDCH DotsOn Wingardium Leviosa PCD RA CGCA CGCU

Dalmatian

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Place of Birth

Québec, Canada

Current Location

Québec, Canada

From

Québec, Canada

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Registration

Canadian Kennel Club (CKC): FU777358
Microchip: 956000006132644

Genetic Breed Result

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Dalmatian

Best known as the star of Disney’s 101 Dalmatians, this sleek and athletic dog breed has a history that goes back several hundred years. He started out as a coach dog but has also served in many other capacities, including hunter, firehouse dog, and circus performer. As charming in life as in film, he goes from gallant to goofy to gallant again in the blink of an eye, and loves to be a part of everything his family does.

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Health Summary

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Leilani inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Urate Kidney & Bladder Stones

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Leilani inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Leilani’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Leilani is unlikely to develop this condition due to this variant because she only has one copy of the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Urate Kidney & Bladder Stones?

This condition causes kidney and bladder stones composed of urate. In most dogs, uric acid is converted to allantoin, an inert substance that is then excreted in the urine. Dogs with HUU have defects in the pathway that converts uric acid to allantoin. As such, uric acid builds up, crystallizes and forms urate stones in the kidney and bladder. Uric acid is an intermediate of purine metabolism. While hyperuricemia in other species (including humans) can lead to painful conditions such as gout, dogs do not develop systemic signs of hyperuricemia.

ALT Activity

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Leilani inherited one copy of the variant we tested

Why is this important to your vet?

Leilani has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Leilani has this genotype, as ALT is often used as an indicator of liver health and Leilani is likely to have a lower than average resting ALT activity. As such, an increase in Leilani’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

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Other Body Features

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Performance

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Through Leilani’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1d

Haplotype

A426

Map

A1d

DotsOn Wingardium Leviosa’s Haplogroup

This female lineage can be traced back about 15,000 years to some of the original Central Asian wolves that were domesticated into modern dogs. The early females that represent this lineage were likely taken into Eurasia, where they spread rapidly. As a result, many modern breed and village dogs from the Americas, Africa, through Asia and down into Oceania belong to this group! This widespread lineage is not limited to a select few breeds, but the majority of Rottweilers, Afghan Hounds and Wirehaired Pointing Griffons belong to it. It is also the most common female lineage among Papillons, Samoyeds and Jack Russell Terriers. Considering its occurrence in breeds as diverse as Afghan Hounds and Samoyeds, some of this is likely ancient variation. But because of its presence in many modern European breeds, much of its diversity likely can be attributed to much more recent breeding.

A426

DotsOn Wingardium Leviosa’s Haplotype

Part of the A1d haplogroup, this haplotype occurs most frequently in mixed-breed dogs.

The vast majority of Rottweilers have the A1d haplogroup.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Leilani inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Leilani is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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