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“Jax”
DM Hilltop Jax

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Registration

American Kennel Club (AKC): PR23778009
Microchip: 900235000070692

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Health Summary

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Jax is at increased risk for one genetic health condition.

Intervertebral Disc Disease (Type I)

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Jax inherited one copy of the variant we tested

How to interpret this result

Jax has one copy of an FGF4 retrogene on chromosome 12. In some breeds such as Beagles, Cocker Spaniels, and Dachshunds (among others) this variant is found in nearly all dogs. While those breeds are known to have an elevated risk of IVDD, many dogs in those breeds never develop IVDD. For mixed breed dogs and purebreds of other breeds where this variant is not as common, risk for Type I IVDD is greater for individuals with this variant than for similar dogs.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

Breed-Relevant Genetic Conditions

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Von Willebrand Disease Type I, Type I vWD (VWF)

Identified in Standard Poodles, Small Poodles, and more

Progressive Retinal Atrophy, prcd (PRCD Exon 1)

Identified in Standard Poodles, Small Poodles, and more

GM2 Gangliosidosis (HEXB, Poodle Variant)

Identified in Standard Poodles, Small Poodles, and more

Degenerative Myelopathy, DM (SOD1A)

Identified in Standard Poodles

Neonatal Encephalopathy with Seizures, NEWS (ATF2)

Identified in Standard Poodles, Small Poodles, and more

Osteochondrodysplasia (SLC13A1, Poodle Variant)

Identified in Standard Poodles, Small Poodles, and more

Additional Genetic Conditions

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