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Darwin

Mixed Breed

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Instagram tag
@Darwinwonderdog

Place of Birth

Columbus, Indiana, USA

Current Location

Indianapolis, Indiana, USA

From

Columbus, Indiana, USA

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Genetic Breed Result

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Embark Supermutt analysis

What’s in that Supermutt? There may be small amounts of DNA from these distant ancestors:

Shetland Sheepdog

Shetland Sheepdogs are a lively, smart and athletic herding dogs that also makes a great family pet.

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Poodle (Small)

A highly intelligent and playful dog, Miniature and Toy Poodles make for great lap dogs and companions.

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Lhasa Apso

An independent breed, the Lhasa's goal in life is not necessarily to please their master. The Lhasa Apso is a small, hardy breed with a beautiful cloak of hair that parts down the back from head to tail. Their temperament is unique: joyful and mischievous, dignified and aloof. Popular in the show ring, the breed also excels at activities that provide constant challenges, such as agility.

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Rat Terrier

The Rat Terrier is an American dog breed with a background as a farm dog and hunting companion.

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American Eskimo Dog

American Eskimo Dogs belong to the spitz family and they actually came from Germany. They got their start in American circuses due to their intelligence. Today, Eskies make wonderful family pets.

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Cocker Spaniel

Cocker Spaniels are handsome and intelligent hunting dogs that are also well-suited to life as a loving family pet.

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Dogs Like Darwin

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Discover dogs who share a similar breed mix to Darwin. A higher score means the two dogs have more of their breed mix in common. A score of 100% means they share the exact same breed mix!

Click or tap on a pic to learn more about each dog and see an in-depth comparison of their DNA, breeds, and more.

DNA Breed Origins

Breed colors:
Shetland Sheepdog
Poodle (Small)
Lhasa Apso
Rat Terrier
American Eskimo Dog
Cocker Spaniel
Supermutt

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Changes to this dog’s profile
  • On 10/22/2020 changed handle from "darwin85" to "darwin0928"

Would you like more information? You can contact us at:

Darwin
Family Tree From Embark PARENTS GRANDPARENTS GREAT GRANDPARENTS Mixed Mixed Shetland Sheepdog / Rat Terrier mix Poodle (Small) / Lhasa Apso mix Shetland Sheepdog / Rat Terrier mix Lhasa Apso / Poodle (Small) mix Shetland Sheepdog Rat Terrier mix Poodle (Small) Lhasa Apso mix Shetland Sheepdog mix Rat Terrier mix Lhasa Apso mix Poodle (Small) mix

Breed Reveal Video

Our algorithms predict this is the most likely family tree to explain Darwin’s breed mix, but this family tree may not be the only possible one.

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Health Summary

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Darwin is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Multiple Drug Sensitivity

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Darwin inherited one copy of the variant we tested

How to interpret this result

Darwin has one copy of a variant at the ABCB1 gene and is at risk for displaying adverse drug reactions. While he may not be as severely affected as a dog with two copies of the ABCB1 drug sensitivity allele, normal dosages of drugs could still have potentially severe effects on Darwin. Please inform your veterinarian that Darwin carries this variant; it is essential that they know this information before prescribing drugs.

What is Multiple Drug Sensitivity?

Sensitivity to certain classes of drugs, notably the parasiticide ivermectin, as well as certain gastroprotectant and anti-cancer medications, occurs in dogs with a mutation in the ABCB1 gene.

ALT Activity

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Darwin inherited one copy of the variant we tested

Why is this important to your vet?

Darwin has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Darwin has this genotype, as ALT is often used as an indicator of liver health and Darwin is likely to have a lower than average resting ALT activity. As such, an increase in Darwin’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Thrombopathia

Identified in American Eskimo Dogs

Von Willebrand Disease Type III, Type III vWD

Identified in Shetland Sheepdogs

Von Willebrand Disease Type I, Type I vWD

Identified in Small Poodles

Congenital Hypothyroidism

Identified in Rat Terriers

Progressive Retinal Atrophy, CNGA

Identified in Shetland Sheepdogs

Progressive Retinal Atrophy, prcd

Identified in American Eskimo Dogs, Cocker Spaniels, and more

Golden Retriever Progressive Retinal Atrophy 1, GR-PRA1

Identified in Lhasa Apsos

Collie Eye Anomaly

Identified in Shetland Sheepdogs

Primary Lens Luxation

Identified in American Eskimo Dogs and Rat Terriers

Familial Nephropathy

Identified in Cocker Spaniels

Glycogen storage disease Type VII, Phosphofructokinase Deficiency, PFK Deficiency

Identified in Cocker Spaniels

GM2 Gangliosidosis

Identified in Small Poodles

Degenerative Myelopathy, DM

Identified in American Eskimo Dogs and Shetland Sheepdogs

Neonatal Encephalopathy with Seizures, NEWS

Identified in Small Poodles

Acral Mutilation Syndrome

Identified in Cocker Spaniels

Exercise-Induced Collapse, EIC

Identified in Cocker Spaniels

Oculocutaneous Albinism, OCA

Identified in Lhasa Apsos

Osteochondrodysplasia

Identified in Small Poodles

Intervertebral Disc Disease (Type I)

Identified in Cocker Spaniels and Small Poodles

Additional Genetic Conditions

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Explore the genetics behind your dog’s appearance and size.

Base Coat Color

Base Coat Color

Coat Color Modifiers

Coat Color Modifiers

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Darwin’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1b

Haplotype

A411

Map

A1b

Darwin’s Haplogroup

This female lineage was very likely one of the original lineages in the wolves that were first domesticated into dogs in Central Asia about 15,000 years ago. Since then, the lineage has been very successful and travelled the globe! Dogs from this group are found in ancient Bronze Age fossils in the Middle East and southern Europe. By the end of the Bronze Age, it became exceedingly common in Europe. These dogs later became many of the dogs that started some of today's most popular breeds, like German Shepherds, Pugs, Whippets, English Sheepdogs and Miniature Schnauzers. During the period of European colonization, the lineage became even more widespread as European dogs followed their owners to far-flung places like South America and Oceania. It's now found in many popular breeds as well as village dogs across the world!

A411

Darwin’s Haplotype

Part of the A1b haplogroup, this haplotype occurs most frequently in Border Collies, Australian Cattle Dogs, and Australian Shepherds.

Some other Embark dogs with this haplotype:

A1b is the most common haplogroup found in German Shepherds.

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Through Darwin’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1b

Haplotype

Ha.7

Map

A1b

Darwin’s Haplogroup

For most of dog history, this haplogroup was probably quite rare. However, a couple hundred years ago it seems to have found its way into a prized male guard dog in Europe who had many offspring, including the ancestors of many European guard breeds such as Doberman Pinchers, St. Bernards, and Great Danes. Despite being rare, many of the most imposing dogs on Earth have it; strangely, so do many Pomeranians! Perhaps this explains why some Poms are so tough, acting like they're ten times their actual size! This lineage is most commonly found in working dogs, in particular guard dogs. With origins in Europe, it spread widely across other regions as Europeans took their dogs across the world.

Ha.7

Darwin’s Haplotype

Part of the A1b haplogroup, this haplotype is found in village dogs from Lebanon and Indonesia. Among breeds, it is also found in Miniature Schnauzer and Toy Poodle.

Some other Embark dogs with this haplotype:

Great Danes and Pomeranians have this in common!

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