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“Chiklet”
Crown Of Curls Batonchik

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Registration

American Kennel Club (AKC): TS57338302
Microchip: 992000000248355

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Health Summary

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Chiklet inherited two variants that you should learn more about.

And one variant that you should tell your vet about.

Progressive Retinal Atrophy, prcd

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Chiklet inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Chiklet’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Chiklet is unlikely to develop this condition due to this variant because she only has one copy of the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Progressive Retinal Atrophy, prcd?

PRA-prcd is a retinal disease that causes progressive, non-painful vision loss. The retina contains cells, called photoreceptors, that collect information about light and send signals to the brain. There are two types of photoreceptors: rods, for night vision and movement, and cones, for day vision and color. This type of PRA leads to early loss of rod cells, leading to night blindness before day blindness.

Proportionate Dwarfism

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Chiklet inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Chiklet’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Chiklet is unlikely to develop this condition due to this variant because she only has one copy of the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Proportionate Dwarfism?

Embark’s data suggests that this variant in the GH1 gene may contribute to a smaller body size. The original publication predicts this is due to a growth hormone (GH) deficiency. However, adult body size is influenced by several different genetic variants. Other changes noted by the publication, including retained baby teeth, persistent puppy-like coats, and low blood sugar have been occasionally reported by owners of dogs with two copies of this variant. These changes may or may not be associated with this variant.

ALT Activity

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Chiklet inherited one copy of the variant we tested

Why is this important to your vet?

Chiklet has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Chiklet has this genotype, as ALT is often used as an indicator of liver health and Chiklet is likely to have a lower than average resting ALT activity. As such, an increase in Chiklet’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Additional Genetic Conditions

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