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“Viggo”
Crimblescurl Hokey Cokey

Curly-Coated Retriever

No bio has been provided yet

Place of Birth

Storbritannia

Current Location

Norge

From

Storbritannia

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Registration

Fédération Cynologique Internationale (FCI): KCAY06115503

Genetic Breed Result

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Curly-Coated Retriever

Curly-Coated Retrievers are intelligent, hard-working, lovable dogs. These guys are believed to be the first retriever breed. Despite being the original, Curlys are now one of the least common retrievers.

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Health Summary

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Viggo is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Exercise-Induced Collapse, EIC

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Viggo inherited both copies of the variant we tested

How to interpret this result

Viggo has two copies of a variant in the DNM1 gene and is at risk for developing EIC. Please note that this variant is known to have incomplete penetrance; that is, a number of dogs who carry two copies of this variant do not exhibit signs of the disease, suggesting that other genetic and environmental factors are required for animals to display signs of EIC. Please consult your veterinarian to discuss further diagnostics, monitoring, and care for Viggo.

What is Exercise-Induced Collapse, EIC?

EIC has been linked to a mutation in the DNM1 gene, which codes for the protein dynamin. In the neuron, dynamin trucks neurotransmitter-filled vesicles from the cell body, where they are generated, to the dendrites. It is hypothesized in dogs affected with EIC, the mutation in DNM1 disrupts efficient neurotransmitter release, leading to a cessation in signalling and EIC.

ALT Activity

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Viggo inherited both copies of the variant we tested

Why is this important to your vet?

Viggo has two copies of a variant in the GPT gene and is likely to have a lower than average baseline ALT activity. ALT is a commonly used measure of liver health on routine veterinary blood chemistry panels. As such, your veterinarian may want to watch for changes in Viggo's ALT activity above their current, healthy, ALT activity. As an increase above Viggo’s baseline ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Progressive Retinal Atrophy, crd4/cord1 (RPGRIP1)

Identified in Curly-Coated Retrievers

Glycogen Storage Disease Type IIIA, GSD IIIA (AGL, Curly Coated Retriever Variant)

Identified in Curly-Coated Retrievers

Additional Genetic Conditions

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Traits

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Coat Color

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Other Coat Traits

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Performance

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Through Viggo’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1d

Haplotype

A247/A522

Map

A1d

Crimblescurl Hokey Cokey’s Haplogroup

This female lineage can be traced back about 15,000 years to some of the original Central Asian wolves that were domesticated into modern dogs. The early females that represent this lineage were likely taken into Eurasia, where they spread rapidly. As a result, many modern breed and village dogs from the Americas, Africa, through Asia and down into Oceania belong to this group! This widespread lineage is not limited to a select few breeds, but the majority of Rottweilers, Afghan Hounds and Wirehaired Pointing Griffons belong to it. It is also the most common female lineage among Papillons, Samoyeds and Jack Russell Terriers. Considering its occurrence in breeds as diverse as Afghan Hounds and Samoyeds, some of this is likely ancient variation. But because of its presence in many modern European breeds, much of its diversity likely can be attributed to much more recent breeding.

A247/A522

Crimblescurl Hokey Cokey’s Haplotype

Part of the A1d haplogroup, the A247/A522 haplotype occurs most frequently in Pomeranians, Dachshunds, and Australian Shepherds.

The vast majority of Rottweilers have the A1d haplogroup.

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Through Viggo’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A2b

Haplotype

Hc.17

Map

A2b

Crimblescurl Hokey Cokey’s Haplogroup

A2b appears to have split a few times in succession, which means that some of the Central Asian male ancestors of this lineage went their separate ways before their respective Y chromosomes made their rounds. There is not much diversity in this lineage, meaning that it has only begun to take off recently. Two iconic breeds, the Dachshund and Bloodhound, represent this lineage well. Over half of Rottweilers are A2b, as are the majority of Labrador Retrievers and Cavalier King Charles Spaniels. While A2a is restricted mostly to East Asia, this paternal line is also found among European breeds.

Hc.17

Crimblescurl Hokey Cokey’s Haplotype

Part of the A2b haplogroup, this haplotype occurs most frequently in mixed breed dogs.

A2b is found in the Daschund breed.

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