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Cosmo

Mixed Breed

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Genetic Breed Result

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Embark Supermutt analysis

What’s in that Supermutt? There may be small amounts of DNA from these distant ancestors:

Great Pyrenees

The Great Pyrenees is an exceptionally loving dog whose primary function is to protect sheep, goats, livestock, people, children, grass, flowers, the moon, lawn furniture, etc., from any real or imaginary predators that may intrude on your personal space. They have a strong build and an amazing thick white coat that exudes elegance and majesty. They make a great family dog because of their intelligence and steady temperament.

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American Pit Bull Terrier

The American Pit Bull Terrier originated in the British Isles and descends from the Mastiff-type dogs introduced to England in antiquity. The breed was brought over to the United States by English immigrants in the 1800s, and quickly became one of the most popular and widespread breeds there.

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German Shepherd Dog

German Shepherds are confident, courageous dogs with a keen sense of smell and notable intelligence. These are active working dogs who excel at many canine sports and tasks -- they are true utility dogs! Their versatility combined with their loyal companionship has them consistently listed as one of the most popular breeds in the United States.

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Labrador Retriever

The Labrador Retriever was bred for hunting and excelled in retrieving game after it was shot down. Known for its gentle disposition and loyalty, the Labrador Retriever has become a favorite of families and breeders alike.

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American Staffordshire Terrier

American Staffordshire Terriers are powerful but playful dogs that are both loyal and affectionate with their owners.

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Dogs Like Cosmo

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Discover dogs who share a similar breed mix to Cosmo. A higher score means the two dogs have more of their breed mix in common. A score of 100% means they share the exact same breed mix!

Click or tap on a pic to learn more about each dog and see an in-depth comparison of their DNA, breeds, and more.

DNA Breed Origins

Breed colors:
Great Pyrenees
American Pit Bull Terrier
German Shepherd Dog
Labrador Retriever
American Staffordshire Terrier
Supermutt

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Cosmo
Family Tree From Embark PARENTS GRANDPARENTS GREAT GRANDPARENTS Mixed Great Pyrenees mix Great Pyrenees / American Pit Bull Terrier mix Labrador Retriever / German Shepherd Dog mix Great Pyrenees American Pit Bull Terrier / German Shepherd Dog mix Great Pyrenees American Pit Bull Terrier mix Labrador Retriever mix German Shepherd Dog mix Great Pyrenees Great Pyrenees American Pit Bull Terrier German Shepherd Dog

Breed Reveal Video

Our algorithms predict this is the most likely family tree to explain Cosmo’s breed mix, but this family tree may not be the only possible one.

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Health Summary

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Cosmo inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Canine Multifocal Retinopathy, cmr1

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Cosmo inherited one copy of the variant we tested

What does this result mean?

This result does not impact your dog’s health. It could have consequences for siblings or other family members, and you should let them know if you are in contact with them. This result is also important if you decide to breed this dog - to produce the healthiest puppies we recommend genetic testing any potential mates for this condition.

What is Canine Multifocal Retinopathy, cmr1?

This is a non-progressive retinal disease that, in rare cases, can lead to vision loss. Dogs with larger lesions can suffer from vision loss. CMR is fairly non-progressive; new lesions will typically stop forming by the time a dog is an adult, and some lesions will even regress with time.

ALT Activity

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Cosmo inherited one copy of the variant we tested

Why is this important to your vet?

Cosmo has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Cosmo has this genotype, as ALT is often used as an indicator of liver health and Cosmo is likely to have a lower than average resting ALT activity. As such, an increase in Cosmo’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Multiple Drug Sensitivity

Identified in German Shepherd Dogs

Hemophilia A

Identified in German Shepherd Dogs

Hemophilia A

Identified in German Shepherd Dogs

Canine Leukocyte Adhesion Deficiency Type III, CLAD III

Identified in German Shepherd Dogs

Canine Elliptocytosis

Identified in Labrador Retrievers

Glanzmann's Thrombasthenia Type I

Identified in Great Pyrenees

Pyruvate Kinase Deficiency

Identified in Labrador Retrievers

Platelet Factor X Receptor Deficiency, Scott Syndrome

Identified in German Shepherd Dogs

Progressive Retinal Atrophy, prcd

Identified in Labrador Retrievers

Golden Retriever Progressive Retinal Atrophy 2, GR-PRA2

Identified in Labrador Retrievers

Progressive Retinal Atrophy, crd1

Identified in American Pit Bull Terriers and American Staffordshire Terriers

Progressive Retinal Atrophy, crd4/cord1

Identified in Labrador Retrievers

Day Blindness

Identified in German Shepherd Dogs

Day Blindness

Identified in Labrador Retrievers

Macular Corneal Dystrophy, MCD

Identified in Labrador Retrievers

Urate Kidney & Bladder Stones

Identified in American Pit Bull Terriers, American Staffordshire Terriers, and more

Anhidrotic Ectodermal Dysplasia

Identified in German Shepherd Dogs

Renal Cystadenocarcinoma and Nodular Dermatofibrosis

Identified in German Shepherd Dogs

Mucopolysaccharidosis Type VII, Sly Syndrome, MPS VII

Identified in German Shepherd Dogs

Neuronal Ceroid Lipofuscinosis, Cerebellar Ataxia, NCL4A

Identified in American Pit Bull Terriers and American Staffordshire Terriers

Alexander Disease

Identified in Labrador Retrievers

Degenerative Myelopathy, DM

Identified in German Shepherd Dogs and Great Pyrenees

L-2-Hydroxyglutaricaciduria, L2HGA

Identified in American Pit Bull Terriers and American Staffordshire Terriers

Narcolepsy

Identified in Labrador Retrievers

Ullrich-like Congenital Muscular Dystrophy

Identified in Labrador Retrievers

Centronuclear Myopathy, CNM

Identified in Labrador Retrievers

Exercise-Induced Collapse, EIC

Identified in Labrador Retrievers

X-Linked Myotubular Myopathy

Identified in Labrador Retrievers

Congenital Myasthenic Syndrome, CMS

Identified in Labrador Retrievers

Hereditary Nasal Parakeratosis, HNPK

Identified in Labrador Retrievers

Skeletal Dysplasia 2, SD2

Identified in Labrador Retrievers

Additional Genetic Conditions

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Explore the genetics behind your dog’s appearance and size.

Base Coat Color

Base Coat Color

Coat Color Modifiers

Coat Color Modifiers

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Cosmo’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

A381

Map

A1a

Cosmo’s Haplogroup

A1a is the most common maternal lineage among Western dogs. This lineage traveled from the site of dog domestication in Central Asia to Europe along with an early dog expansion perhaps 10,000 years ago. It hung around in European village dogs for many millennia. Then, about 300 years ago, some of the prized females in the line were chosen as the founding dogs for several dog breeds. That set in motion a huge expansion of this lineage. It's now the maternal lineage of the overwhelming majority of Mastiffs, Labrador Retrievers and Gordon Setters. About half of Boxers and less than half of Shar-Pei dogs descend from the A1a line. It is also common across the world among village dogs, a legacy of European colonialism.

A381

Cosmo’s Haplotype

Part of the large A1a haplogroup, this haplotype occurs most frequently in German Shepherd Dogs, Doberman Pinschers, and Dachshunds.

Some other Embark dogs with this haplotype:

Shar Pei dogs think A1a is the coolest!

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Through Cosmo’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

E

Haplotype

H8.1

Map

E

Cosmo’s Haplogroup

The E lineage is sticking around to remind dog lovers of a truly ancient ancestor among all modern domestic dogs. Males with this Y chromosome type are reminiscent of dog-like canids reaching deep into the most recent ice age (the Pleistocene). E is much more common among village dogs than breeds. However, it is found as a minor lineage among the Basenji breed, as well as the ancient Canaan dog, which has been present in the Middle East for thousands of years. E is present widely among African village dog populations, as well as among some Mongolian dogs. With its greatest diversity and most frequent occurrences popping up in the Middle East, this lineage extends all the way over into India. Thus, African, South Asian, and Central Asian populations may descend from founders in this region, perhaps somehow tied to the spread of agriculture.

H8.1

Cosmo’s Haplotype

Part of the E haplogroup, this haplotype has been spotted in Basenjis, Canaan Dogs, and village dogs spanning from Africa into the Middle East.

Some other Embark dogs with this haplotype:

An example of a Basenji.

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