“Fate”
INT'CH UWP MRBIMBS MBIMBS MBOTBIS EGCH Coruscate's Remember The Buster SPOT CA BCAT CGC CGCA CGCU TKN

Doberman Pinscher

  • Photo of Fate, a Doberman Pinscher  in Georgia, USA Photo of Fate, a Doberman Pinscher  in Georgia, USA

“Service dog in Training. 2019 #2 Doberman Pinscher in UKC”

Instagram tag
@doberdiva_princesspit

Place of Birth
Georgia, USA
Current Location
Florida, USA
From
Georgia, USA

This dog has been viewed 398 times and been given 8 wags

Genetic Breed Result

Learn how it’s done

Doberman Pinscher

100.0% Doberman Pinscher
Doberman Pinscher Doberman Pinscher
Doberman Pinschers are a strong and athletic breed that are built to guard and protect.
Learn More
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Genetic Stats


Predicted Adult Weight
Genetic Age
30 human years Learn More
Based on the date of birth provided

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Explore by tapping the parents and grandparents.

Our algorithms predict this is the most likely family tree to explain Fate’s breed mix, but this family tree may not be the only possible one.

Health Summary

Fate is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Dilated Cardiomyopathy, DCM2

Fate inherited both copies of the variant we tested

How to interpret this result

Fate has two copies of a variant in TTN gene associated with increased risk for DCM in the American Doberman Pinscher. This variant, also referred to as DCM2, is inherited in a dominant manner, meaning having one or two copies of this variant is thought to confer the same amount of risk. However, the variant is thought to have incomplete penetrance: That is, not all dogs with this variant will ultimately show signs of DCM. Moreover, the impact of this variant in other breeds of dog besides the Doberman has yet to be fully understood. However, if your veterinarian thinks Fate shows signs of having DCM based on their diagnostic testing, you now have the opportunity to discuss early treatment. Please consult with your veterinarian regarding a diagnostic and treatment plan for Fate. We measure this result using a linkage test.

What is Dilated Cardiomyopathy, DCM2?

DCM is the most common acquired heart disease of adult dogs. The heart has two heavily muscled ventricles that pump blood away from the heart. This disease causes progressive weakening of the ventricles by reducing the muscle mass, which causes the ventricles to dilate. Dilated ventricles do not contract and circulate oxygenated blood well, which eventually leads to heart failure.

ALT Activity

Fate inherited one copy of the variant we tested

Why is this important to your vet?

Fate has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Fate has this genotype, as ALT is often used as an indicator of liver health and Fate is likely to have a lower than average resting ALT activity. As such, an increase in Fate’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

Von Willebrand Disease Type I (VWF)

Identified in Doberman Pinschers

Deafness and Vestibular Syndrome of Dobermans, DVDob, DINGS (MYO7A)

Identified in Doberman Pinschers

Dilated Cardiomyopathy, DCM1 (PDK4)

Identified in Doberman Pinschers

Additional Genetic Conditions

Explore the genetics behind your dog’s appearance and size.
Coat Color

Coat Color

E Locus (MC1R)
No dark mask or grizzle (EE)
K Locus (CBD103)
More likely to have a patterned haircoat (kyky)
A Locus (ASIP)
Black/Brown and tan coat color pattern (atat)
D Locus (MLPH)
Dark areas of hair and skin are not lightened (DD)
B Locus (TYRP1)
Black or gray hair and skin (Bb)
Saddle Tan (RALY)
Likely saddle tan patterned (NI)
S Locus (MITF)
Likely flash, parti, or piebald (Ssp)
M Locus (PMEL)
No merle alleles (mm)
Other Coat Traits

Other Coat Traits

Furnishings (RSPO2) LINKAGE
Likely unfurnished (no mustache, beard, and/or eyebrows) (II)
Coat Length (FGF5)
Likely short or mid-length coat (GG)
Shedding (MC5R)
Likely light to moderate shedding (TT)
Coat Texture (KRT71)
Likely straight coat (CC)
Hairlessness (FOXI3) LINKAGE
Very unlikely to be hairless (NN)
Hairlessness (SGK3)
Very unlikely to be hairless (NN)
Oculocutaneous Albinism Type 2 (SLC45A2) LINKAGE
Likely not albino (NN)
Other Body Features

Other Body Features

Muzzle Length (BMP3)
Likely medium or long muzzle (CC)
Tail Length (T)
Likely normal-length tail (CC)
Hind Dewclaws (LMBR1)
Unlikely to have hind dew claws (CC)
Blue Eye Color (ALX4) LINKAGE
Less likely to have blue eyes (NN)
Back Muscling & Bulk, Large Breed (ACSL4)
Likely normal muscling (CC)
Body Size

Body Size

Body Size (IGF1)
Larger (NN)
Body Size (IGFR1)
Larger (GG)
Body Size (STC2)
Larger (TT)
Body Size (GHR - E191K)
Larger (GG)
Body Size (GHR - P177L)
Larger (CC)
Performance

Performance

Altitude Adaptation (EPAS1)
Normal altitude tolerance (GG)
Appetite (POMC) LINKAGE
Normal food motivation (NN)

Through Fate’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

B1

Haplotype

B45

Map

B1

Coruscate's Remember The Buster’s Haplogroup

B1 is the second most common maternal lineage in breeds of European or American origin. It is the female line of the majority of Golden Retrievers, Basset Hounds, and Shih Tzus, and about half of Beagles, Pekingese and Toy Poodles. This lineage is also somewhat common among village dogs that carry distinct ancestry from these breeds. We know this is a result of B1 dogs being common amongst the European dogs that their conquering owners brought around the world, because nowhere on earth is it a very common lineage in village dogs. It even enables us to trace the path of (human) colonization: Because most Bichons are B1 and Bichons are popular in Spanish culture, B1 is now fairly common among village dogs in Latin America.

B45

Coruscate's Remember The Buster’s Haplotype

Part of the large B1 haplogroup, this haplotype occurs most commonly in Yorkshire Terriers, Doberman Pinschers, Cocker Spaniels, and village dogs in Costa Rica.

Some other Embark dogs with this haplotype:

The B1 haplogroup can be found in village dogs like the Peruvian Village Dog, pictured above.

Through Fate’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1b

Haplotype

Ha.3

Map

A1b

Coruscate's Remember The Buster’s Haplogroup

For most of dog history, this haplogroup was probably quite rare. However, a couple hundred years ago it seems to have found its way into a prized male guard dog in Europe who had many offspring, including the ancestors of many European guard breeds such as Doberman Pinchers, St. Bernards, and Great Danes. Despite being rare, many of the most imposing dogs on Earth have it; strangely, so do many Pomeranians! Perhaps this explains why some Poms are so tough, acting like they're ten times their actual size! This lineage is most commonly found in working dogs, in particular guard dogs. With origins in Europe, it spread widely across other regions as Europeans took their dogs across the world.

Ha.3

Coruscate's Remember The Buster’s Haplotype

Part of the A1b haplogroup, this haplotype is found in village dogs in Peru and the French Polynesian Islands. It is also common among Doberman Pinscher, Saint Bernard, and Rhodesian Ridgeback.

Some other Embark dogs with this haplotype:

Great Danes and Pomeranians have this in common!