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“Daisy”
Clussexx That's What Girls Are Made Of

Clumber Spaniel

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Place of Birth

Bloomington, IN, USA

Current Location

Spruce Grove, AB, Canada

From

Bloomington, IN, USA

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Registration

American Kennel Club (AKC): SS01115102

Genetic Breed Result

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Clumber Spaniel

Clumber Spaniels are cumbersome looking fellows. With their droopy expression, short legs, and long body, they don’t look like the athletes that they are supposed to be. But don’t be fooled by appearances—Clumber Spaniels were originally bred in their native Great Britain to hunt partridges and other land fowl. While they aren’t as fast as their other Spaniel counterparts, they make up for their lack of speed with a quiet diligence and a good nose for hunting.

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Genetic Stats

Predicted Adult Weight

54 lbs

Genetic Age
44 human years

Based on the date of birth provided

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Health Summary

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Daisy is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Intervertebral Disc Disease (Type I)

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Daisy inherited both copies of the variant we tested

What does this result mean?

Follow-up by our experts indicates that this genetic variant is associated with an increase to Daisy’s risk for developing Intervertebral Disc Disease (Type I).

Scientific Basis

Research studies for this variant have been based on dogs of other breeds. While dogs with similar breeds to Daisy have not yet been the focus of research studies, our data indicates that Daisy is likely to be at increased risk.

Impact on Breeding

While further investigation is warranted to determine the clinical presentation and penetrance in Daisy’s breed, we recommend taking this genetic result into account when making breeding decisions.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

ALT Activity

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Daisy inherited both copies of the variant we tested

Why is this important to your vet?

Daisy has two copies of a variant in the GPT gene and is likely to have a lower than average baseline ALT activity. ALT is a commonly used measure of liver health on routine veterinary blood chemistry panels. As such, your veterinarian may want to watch for changes in Daisy's ALT activity above their current, healthy, ALT activity. As an increase above Daisy’s baseline ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Exercise-Induced Collapse, EIC (DNM1)

Identified in Clumber Spaniels

Pyruvate Dehydrogenase Deficiency (PDP1, Spaniel Variant)

Identified in Clumber Spaniels

Additional Genetic Conditions

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Through Daisy’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1b

Haplotype

A361/409/611

Map

A1b

Clussexx That's What Girls Are Made Of’s Haplogroup

This female lineage was very likely one of the original lineages in the wolves that were first domesticated into dogs in Central Asia about 15,000 years ago. Since then, the lineage has been very successful and travelled the globe! Dogs from this group are found in ancient Bronze Age fossils in the Middle East and southern Europe. By the end of the Bronze Age, it became exceedingly common in Europe. These dogs later became many of the dogs that started some of today's most popular breeds, like German Shepherds, Pugs, Whippets, English Sheepdogs and Miniature Schnauzers. During the period of European colonization, the lineage became even more widespread as European dogs followed their owners to far-flung places like South America and Oceania. It's now found in many popular breeds as well as village dogs across the world!

A361/409/611

Clussexx That's What Girls Are Made Of’s Haplotype

Part of the A1b haplogroup, this haplotype occurs most frequently in German Shepherd Dogs, Poodles, and Shiloh Shepherds.

Some other Embark dogs with this haplotype:

A1b is the most common haplogroup found in German Shepherds.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Daisy inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Daisy is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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