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“Feisty”
CH Witzn Wizards Only TKN

Sealyham Terrier

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  • Photo of Feisty, a Sealyham Terrier  in Texas, USA Photo of Feisty, a Sealyham Terrier  in Texas, USA
    CH WITZN WIZARDS ONLY, TKN

“Feisty is a sweet, wonderful boy. Exceptionally sound and good moving.”

Place of Birth

Texas, USA

Current Location

Texas, USA

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Registration

American Kennel Club (AKC): RN28845702

Genetic Breed Result

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Sealyham Terrier

Sealyham Terriers are a unique looking terrier from Wales. With their mustache and prominent eyebrows, they are truly unmistakable little dogs!

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Changes to this dog’s profile
  • On 1/6/2020 changed name from "CH Witzn Wizards Only" to "Witzn Wizards Only"

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Health Summary

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Feisty is at increased risk for two genetic health conditions.

And inherited two variants that you should learn more about.

Primary Lens Luxation

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Feisty inherited one copy of the variant we tested

How to interpret this result

Feisty has one copy of a variant in the ADAMTS17 gene and is at some risk for developing PLL. This variant is known to have an additive effect, so while dogs with one copy of the variant like Feisty have a higher risk than dogs with two healthy alleles at ADAMTS17, their risk is much lower than a dog with two copies of the variant. Actual risk associated with having one copy of this variant appears to vary in a breed-specific manner. A study published by Gould et al 2011 supports that Tibetan Terriers with one copy of the variant have minimal risk of developing PLL, whereas this risk can range from 2-20% in other terrier breeds. Please consult with your veterinarian to discuss the best ways to monitor Feisty's eyes and vision.

What is Primary Lens Luxation?

PLL occurs when the lens spontaneously detaches from its normal residence within the pupil, leading to reduced visual acuity. Anterior lens luxation is when the lens falls forward and posterior lens luxation is when the lens falls backwards in the eye.

Intervertebral Disc Disease (Type I)

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Feisty inherited one copy of the variant we tested

What does this result mean?

Follow-up by our experts indicates that this genetic variant is associated with an increase to Feisty’s risk for developing Intervertebral Disc Disease (Type I).

Scientific Basis

Research studies for this variant have been based on dogs of other breeds. While dogs with similar breeds to Feisty have not yet been the focus of research studies, our data indicates that Feisty is likely to be at increased risk.

Impact on Breeding

While further investigation is warranted to determine the clinical presentation and penetrance in Feisty’s breed, we recommend taking this genetic result into account when making breeding decisions.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

Factor VII Deficiency

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Feisty inherited one copy of the variant we tested

What does this result mean?

Because this variant is inherited in an autosomal recessive manner (meaning dogs need two copies of the variant to develop the disease), Feisty is unlikely to develop this condition due to the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of his offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Factor VII Deficiency?

Factor VII deficiency is a type of coagulopathy, a disorder of blood clotting. It is characterized by mild to moderate abnormal bleeding (generally less severe than that caused by deficiencies in other clotting factors such as as Factors VIII or IX). Some dogs with this condition will show no clinical signs.

ALT Activity

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Feisty inherited one copy of the variant we tested

Why is this important to your vet?

Feisty has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Feisty has this genotype, as ALT is often used as an indicator of liver health and Feisty is likely to have a lower than average resting ALT activity. As such, an increase in Feisty’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Additional Genetic Conditions

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Through Feisty’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

B1

Haplotype

B81

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B1

Witzn Wizards Only’s Haplogroup

B1 is the second most common maternal lineage in breeds of European or American origin. It is the female line of the majority of Golden Retrievers, Basset Hounds, and Shih Tzus, and about half of Beagles, Pekingese and Toy Poodles. This lineage is also somewhat common among village dogs that carry distinct ancestry from these breeds. We know this is a result of B1 dogs being common amongst the European dogs that their conquering owners brought around the world, because nowhere on earth is it a very common lineage in village dogs. It even enables us to trace the path of (human) colonization: Because most Bichons are B1 and Bichons are popular in Spanish culture, B1 is now fairly common among village dogs in Latin America.

B81

Witzn Wizards Only’s Haplotype

Part of the large B1 haplogroup, this haplotype occurs most frequently in Shih Tzus, Chihuahuas, and Poodles.

Some other Embark dogs with this haplotype:

The B1 haplogroup can be found in village dogs like the Peruvian Village Dog, pictured above.

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Through Feisty’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A2b

Haplotype

Hc.9

Map

A2b

Witzn Wizards Only’s Haplogroup

A2b appears to have split a few times in succession, which means that some of the Central Asian male ancestors of this lineage went their separate ways before their respective Y chromosomes made their rounds. There is not much diversity in this lineage, meaning that it has only begun to take off recently. Two iconic breeds, the Dachshund and Bloodhound, represent this lineage well. Over half of Rottweilers are A2b, as are the majority of Labrador Retrievers and Cavalier King Charles Spaniels. While A2a is restricted mostly to East Asia, this paternal line is also found among European breeds.

Hc.9

Witzn Wizards Only’s Haplotype

Part of the A2b haplogroup, this haplotype is found in village dogs spanning South America, Africa, and the South Pacific. Among the breeds we have spotted it in, the most frequent occurrences are in Dachshund, Bloodhound, American Eskimo Dog, and Jack Russell Terrier.

Some other Embark dogs with this haplotype:

A2b is found in the Daschund breed.

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