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CH Fireside's Calypso Moon

Welsh Springer Spaniel

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Place of Birth

Mahwah, NJ, USA

Current Location

Mahwah, NJ, USA

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Registration

American Kennel Club (AKC): SS09636501

Genetic Breed Result

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Welsh Springer Spaniel

Welsh Springer Spaniels are special because they are one of the few breeds to come from Wales. With their loving expressions and beautiful, pendulous ears, Welsh Springer Spaniels are dogs that exhibit vibrant and sweet personalities. While it’s unclear exactly how old the breed is, there are many paintings spanning back hundreds of years that feature similar looking red and white dogs. It’s possible their predecessors existed in the 1500s. They are likely a mix of other European Spaniels, like the English Springer Spaniel and the French Brittany. Mostly unknown outside of the United Kingdom, Welsh Springer Spaniels gained official recognition from The Kennel Club in the early 1900s. After they began winning in field trials and conformation shows, they quickly gained popularity.

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Health Summary

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CH Fireside's Calypso Moon is at increased risk for one genetic health condition.

And inherited two variants that you should learn more about.

Intervertebral Disc Disease (Type I)

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CH Fireside's Calypso Moon inherited both copies of the variant we tested

What does this result mean?

Follow-up by our experts indicates that this genetic variant is associated with an increase to CH Fireside's Calypso Moon’s risk for developing Intervertebral Disc Disease (Type I).

Scientific Basis

Research studies for this variant have been based on dogs of other breeds. While dogs with similar breeds to CH Fireside's Calypso Moon have not yet been the focus of research studies, our data indicates that CH Fireside's Calypso Moon is likely to be at increased risk.

Impact on Breeding

While further investigation is warranted to determine the clinical presentation and penetrance in CH Fireside's Calypso Moon’s breed, we recommend taking this genetic result into account when making breeding decisions.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

Factor VII Deficiency

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CH Fireside's Calypso Moon inherited one copy of the variant we tested

What does this result mean?

This result should not impact CH Fireside's Calypso Moon’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring.

What is Factor VII Deficiency?

Factor VII deficiency is a type of coagulopathy, a disorder of blood clotting. It is characterized by mild to moderate abnormal bleeding (generally less severe than that caused by deficiencies in other clotting factors such as as Factors VIII or IX). Some dogs with this condition will show no clinical signs.

ALT Activity

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CH Fireside's Calypso Moon inherited both copies of the variant we tested

Why is this important to your vet?

CH Fireside's Calypso Moon has two copies of a variant in the GPT gene and is likely to have a lower than average baseline ALT activity. ALT is a commonly used measure of liver health on routine veterinary blood chemistry panels. As such, your veterinarian may want to watch for changes in CH Fireside's Calypso Moon's ALT activity above their current, healthy, ALT activity. As an increase above CH Fireside's Calypso Moon’s baseline ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Familial Nephropathy (COL4A4 Exon 3, Cocker Spaniel Variant)

Identified in Welsh Springer Spaniels

Additional Genetic Conditions

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Through CH Fireside's Calypso Moon’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1b

Haplotype

A361/409/611

Map

A1b

CH Fireside's Calypso Moon’s Haplogroup

This female lineage was very likely one of the original lineages in the wolves that were first domesticated into dogs in Central Asia about 15,000 years ago. Since then, the lineage has been very successful and travelled the globe! Dogs from this group are found in ancient Bronze Age fossils in the Middle East and southern Europe. By the end of the Bronze Age, it became exceedingly common in Europe. These dogs later became many of the dogs that started some of today's most popular breeds, like German Shepherds, Pugs, Whippets, English Sheepdogs and Miniature Schnauzers. During the period of European colonization, the lineage became even more widespread as European dogs followed their owners to far-flung places like South America and Oceania. It's now found in many popular breeds as well as village dogs across the world!

A361/409/611

CH Fireside's Calypso Moon’s Haplotype

Part of the A1b haplogroup, this haplotype occurs most frequently in German Shepherd Dogs, Poodles, and Shiloh Shepherds.

Some other Embark dogs with this haplotype:

A1b is the most common haplogroup found in German Shepherds.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that CH Fireside's Calypso Moon inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since CH Fireside's Calypso Moon is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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