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Charisma’s Reign of Fire “Missandi”

English Toy Spaniel

“She is extremely bouncy and snuggly.”

Place of Birth

Shillington, Pennsylvania, USA

Current Location

Gap, Pennsylvania, USA

From

Shillington, Pennsylvania, USA

This dog has been viewed and been given 1 wag

Registration

American Kennel Club (AKC): TS52361702

Genetic Breed Result

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English Toy Spaniel

The English Toy Spaniel is a small, kind, and lovable little dog. These guys were held in high regard by English royalty. They are wonderfully suited for appartment living and make great lapdogs.

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Health Summary

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Charisma’s Reign of Fire “Missandi” is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Intervertebral Disc Disease (Type I)

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Charisma’s Reign of Fire “Missandi” inherited both copies of the variant we tested

What does this result mean?

Follow-up by our experts indicates that this genetic variant is associated with an increase to Charisma’s Reign of Fire “Missandi”’s risk for developing Intervertebral Disc Disease (Type I).

Scientific Basis

Research studies for this variant have been based on dogs of other breeds. While dogs with similar breeds to Charisma’s Reign of Fire “Missandi” have not yet been the focus of research studies, our data indicates that Charisma’s Reign of Fire “Missandi” is likely to be at increased risk.

Impact on Breeding

While further investigation is warranted to determine the clinical presentation and penetrance in Charisma’s Reign of Fire “Missandi”’s breed, we recommend taking this genetic result into account when making breeding decisions.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

Degenerative Myelopathy, DM

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Charisma’s Reign of Fire “Missandi” inherited both copies of the variant we tested

What does this result mean?

We do not know whether this increases the risk that Charisma’s Reign of Fire “Missandi” will develop Degenerative Myelopathy, DM.

Scientific Basis

Research studies for this variant have been based on dogs of other breeds. Not enough dogs with Charisma’s Reign of Fire “Missandi”'s breed have been studied to know whether or not this variant will increase Charisma’s Reign of Fire “Missandi”'s risk of developing this disease.

Impact on Breeding

Research into the clinical impact of this variant is ongoing. We recommend tracking this genetic result and incidence of Degenerative Myelopathy, DM in your breeding program and related dogs.

What is Degenerative Myelopathy, DM?

The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.

Breed-Relevant Genetic Conditions

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Dry Eye Curly Coat Syndrome (FAM83H Exon 5)

Identified in English Toy Spaniels

Muscular Dystrophy (DMD, Cavalier King Charles Spaniel Variant 1)

Identified in English Toy Spaniels

Episodic Falling Syndrome (BCAN)

Identified in English Toy Spaniels

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

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Through Charisma’s Reign of Fire “Missandi”’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

A388

Map

A1a

Charisma’s Reign of Fire “Missandi”’s Haplogroup

A1a is the most common maternal lineage among Western dogs. This lineage traveled from the site of dog domestication in Central Asia to Europe along with an early dog expansion perhaps 10,000 years ago. It hung around in European village dogs for many millennia. Then, about 300 years ago, some of the prized females in the line were chosen as the founding dogs for several dog breeds. That set in motion a huge expansion of this lineage. It's now the maternal lineage of the overwhelming majority of Mastiffs, Labrador Retrievers and Gordon Setters. About half of Boxers and less than half of Shar-Pei dogs descend from the A1a line. It is also common across the world among village dogs, a legacy of European colonialism.

A388

Charisma’s Reign of Fire “Missandi”’s Haplotype

Part of the large A1a haplogroup, this haplotype occurs most frequently in Staffordshire Terriers, Labrador Retrievers, and English Bulldogs.

Shar Pei dogs think A1a is the coolest!

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Charisma’s Reign of Fire “Missandi” inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Charisma’s Reign of Fire “Missandi” is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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