Ceili inherited one copy of the variant we tested
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“Ceili is a purebred Soft Coated Wheaten Terrier. She is a confident and playful girl, super independent and fearless when it comes to trying new things. She loves to snuggle and go on walks. Ceili has a pretty big case of FOMO and loves to be included in all the action. She even loves to be held facing forward so she doesn't miss anything!”
Place of Birth
Ontario, Canada
Current Location
High River, AB, Canada
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Registration
American Kennel Club
(AKC):
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Changes to this dog’s profile
- On 5/21/2022 changed handle from "fergie118" to "ceili10"
- On 5/10/2022 changed name from "Fergie" to "Ceili"
Our policy is that each dog’s profile should accurately portray the dog to which the genetic reports belong.
To help ensure adherence to this policy, we show here any changes that have been made to the name or handle (web address) of this dog.
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Health Summary
Ceili is at increased risk for one genetic health condition.
And inherited one variant that you should learn more about.
Protein Losing Nephropathy, PLN
How to interpret this result
Ceili has one copy of a variant at NPHS1 and is at risk for developing PLN. Genetic studies have indicated that other factors, both genetic and environmental, play a role in causing PLN, especially in the case of dogs who carry just one copy of the variant, like yours: so while Ceili's genotype indicates that he or she is at risk for developing PLN, it is not predictive. Please consult with your veterinarian to develop a plan for further diagnostics, monitoring, and care for Ceili.
What is Protein Losing Nephropathy, PLN?
Protein Losing Nephropathy causes inappropriate loss of protein in the urine. Certain parts of the kidney act as a sieve where ions, small molecules like urea, and water are filtered out of the blood into the urine. In PLN, the sieve is compromised and protein moves in the urine. This leads to muscle wasting, abnormal fluid accumulation in the skin and limbs, and kidney failure.
Degenerative Myelopathy, DM
Ceili inherited one copy of the variant we tested
What does this result mean?
This variant should not impact Ceili’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Ceili is unlikely to develop this condition due to this variant because she only has one copy of the variant.
Impact on Breeding
Your dog carries this variant and will pass it on to ~50% of her offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.
What is Degenerative Myelopathy, DM?
The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.
Breed-Relevant Genetic Conditions
Microphthalmia (RBP4 Exon 2, Soft Coated Wheaten Terrier Variant)
Identified in Soft Coated Wheaten Terriers
Variant not detected
Paroxysmal Dyskinesia, PxD (PIGN)
Identified in Soft Coated Wheaten Terriers
Variant not detected
Additional Genetic Conditions
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What is a linkage test?
DNA sequences that are close together on a chromosome tend to be inherited together. Because of this, we can use genetic variation surrounding a specific variant (i.e. "linked" to it) to infer the presence or absence of a variant that is associated with a health condition or trait.
Linkage tests are not as predictive of your dog’s true genotype as direct assays, which we use on most other genetic conditions we test for.
Traits
Explore the genetics behind your dog’s appearance and size.
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Coat Color
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Other Coat Traits
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Other Body Features
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Body Size
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.